フローサイトメトリー 改訂第5版 手技と実際

出版社： 癌と化学療法社
著者：
発行日： 1994-04-20
分野： 基礎・関連科学  >  医用工学/材料
電子書籍版： 1994-04-20 （第5版増刷）
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「フローサイトメトリー　―手技と実際―」に、最新の重要な手技を加え、新しい成果を盛り込んだ改訂版。

目次

  • 表紙
  • 執筆者一覧
  • 目次
  • I. 巻頭言
  • II. 歴史
  • III. 定義および原理
  • IV. 試料作製法
  • 1. 細胞浮遊液の作製と保存
  • 1) 浮遊細胞
  • 2) 固形細胞
  • a) 新鮮材料
  • b) 固定材料(パラフィン包埋)
  • 2. 染色法
  • 1) 蛍光物質概論
  • 2) DNA
  • 3) RNA
  • 4) Acridine Orange, FITC染色
  • 5) 表面抗原
  • 6) BrdU標識
  • 7) 生細胞と死細胞
  • 8) Hoechst 33342によるDNAの生体染色
  • 3. 標準試料
  • V. 測定の実際とトラブルの解決法
  • VI. セル・ソーティング
  • VII. 応用
  • 1. モノクローナル抗体
  • 1) モノクローナル抗体作製への応用
  • 2) 細胞表面抗原検索
  • a) リンパ球亜群
  • イ) 固形腫瘍
  • ロ) 造血器腫瘍
  • ハ) 自己免疫疾患
  • ニ) エイズとフローサイトメトリー
  • ホ) BRM
  • b) 腫瘍細胞
  • イ) 白血病
  • ロ) 白血病(市販MoAbによる)
  • ハ) Flow cytometryによる悪性リンパ腫の免疫診断
  • c) 赤血球
  • d) 血小板
  • 3) 細胞内抗原検索
  • 2. 核DNA量の解析
  • 1) 細胞生物学に関する応用
  • a) 細胞加齢とDNA量
  • b) 脳腫瘍
  • c) 肺癌
  • d) 胃癌, 大腸癌
  • e) 肝硬変, 肝癌
  • f) 子宮癌
  • g) 造血器腫瘍(成人)
  • h) 造血器腫瘍(小児)
  • i) 腎臓癌
  • j) 膀胱癌
  • 2) 細胞回転と癌化学療法
  • a) 細胞周期の解析
  • b) 抗癌剤
  • イ) 作用機序の解析
  • ロ) 感受性の解析
  • ハ) シンクロナイゼーション
  • ニ) 女性性器癌の細胞周期とステロイトホルモン担体による標的癌化学療法
  • 3. BrdUによる生長解析
  • 1) 抗BrdU抗体によるDNA合成細胞の染色-理論と方法-
  • 2) 臨床応用
  • a) 腫瘍の成長解析
  • b) 化学療法の解析
  • 4. セル・ソーティングの応用
  • 1) 染色体の分析と分離
  • 2) FACSの分子生物学への応用
  • 3) 化学療法への応用
  • 4) 肝・腎細胞の分離
  • 5. Multiparameterを用いた生物学的応用
  • 1) DNA・RNA, 蛋白計量による子宮頸癌スクリーニング
  • 2) DNA-蛋白, DNA-Scatter分析による癌の診断
  • 3) Scatter併用による子宮頸癌の診断
  • 4) Light scatteringの診断学的応用
  • VIII. データ解析法
  • 1. DNA分布の解析
  • 2. 抗原検索における解析
  • 3. コンペンセーション
  • IX. その他
  • 1. FCMによる貪食能の解析(仮題)
  • 2. 細胞の抗癌剤取り込み排出のFCMによる解析
  • 3. 癌細胞のDNA basepairよりみた制癌効果の多角的解析
  • 4. 固形癌のPhenotypic Surface MarkerとGrowth Factor Receptorの解析-転移癌細胞検出へのアプローチ-
  • X. 新しいFCMの装置
  • XI. 各種機器
  • 1. Ortho
  • 2. Fluorescence Activated Cell Sorter(FACS, Becton Dickinson)
  • 3. PARTEC
  • 4. FCS-1, FCM-1D, Cyto ACE
  • 5. EPICS
  • 巻末言
  • FCM略語・用語集
  • 索引
  • 奥付
  • 〔編著者略歴〕

この書籍の参考文献

参考文献のリンクは、リンク先の都合等により正しく表示されない場合がありますので、あらかじめご了承下さい。

本参考文献は電子書籍掲載内容を元にしております。

II. 歴史

P.9 掲載の参考文献
1) Herzenberg, L. A., et al:Fluorescence activated cell sorting. Scientific American 234:108, 1976.
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2) Van Dilla, M. A. et al:Cell microfluorometry:A method for rapid fluorescence measurement. Science 163:1213, 1969.
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3) Gohde, W.:Automation of cytofluorometry by use of the impulsmicrophotometer. In:Fluorescence technique in cell biology, Eds. by Thaer, A. A. and Sernetz, M. Springer, Berlin, p.79, 1973.
 
4) Nicolini, C., et al:Physical-chemical characterization of living cells by laser flow microfluorometry. Cancer Treat. Rep.60:1819, 1976.
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5) Gohde, W., et al:Simultarre impulsfluorimetrie des DNS und proteingehaltes von tumorzellen. Z. Anal. Chem. 252:328, 1970.
 
6) Fulwyler, M. J.:Electronic separation of biological cells by volume. Science 150:910, 1965.
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7) Loken, M. R. et al:Analysis of cell populations with a fluorescence-activated cell sorter. Ann. N. Y. Acad. Sci. 254:163, 1975.
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8) Stout, R. D. et al:The Fc receptor on thymusderived lymphocytes. I. Detection of a subpopulation of murine T lymphocytes bearing the Fc receptor. J. Exp.Med. 142:611, 1975.
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9) Okumura, K. et al:Specific enrichment of the suppressor T cell bearing I-J determinants. Parallel functional and serological characterizations. J. Exp.Med. 146:1234, 1977.
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10) 奥村 康・他:FACSとその応用. 感染・炎症・免疫 7:202, 1977.
 
11) Melamed, M. R. et al:Acridine orange metachromasia for characterization of Leukocytes in leukemia, lymphoma and other neoplasmas. Cancer 29:1361, 1972.
 
12) Yataganas, X., et al:Flow-microfluorometric analysis of cell killing with cytotoxic drugs. J. Histochemi. Cytochemi, 22:651, 1974.
 
13) Yataganas, X., Mitomo, Y. et al:Evaluation of a feulgentype reaction in suspension using flow microfluorimetry and a cell separation technique. Acta Cytol. 19:71, 1975.
 
14) Reynolds, O.:An experimental investigation of the circumstances which determine whether the motion of water shall be direct or sinuous, and of the law of resistance in channels. Phil. Trans. 935, 1883.
 
15) Adams, L. R., et al:Machine characterization of human leukocytes by acridine orange fluorescence. Acta Cytol. 15:289, 1971.
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16) Trujillo, T. T., et al:Adaptation of the fluorescent feulgen reaction to cell in suspension for flow microfluorometry. Acta Cytol. 16:26, 1972.
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17) Krishan, A.:Rapid flow cytofluorometric analysis of mammalian cell cycle by propidium iodide staining. J. Cell Biol. 66:188, 1975.
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18) Lepecq, J. B., et al:A fluorescent complex between ethidium bromide and nucleic acids. J. Mol. Biol. 27:87, 1967.
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19) Tobey, R. A., et al:Use of flow microfluorometry in detailed analysis of effects of chemical agents on cell cycle progression. Cancer Res. 32:2726, 1972.
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20) Fried, J., et al:Kinetic response of human leukemic and lymphoma cells in vivo to combination chemotherapy using flow microfluorometry. Cancer Treat. Rep.60:1937, 1976.
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21) 御供泰治・他:DNA瞬間自動測定装置およびその応用. 医学のあゆみ 97:863, 1976.
 
22) 太田和雄・他:DNA瞬間自動測定装置. 癌と化学療法 4:179, 1977.
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23) Buchner, T., et al:Accumulation of S-phase cells in the bone marrow of patients with acute leukemia by cytosine arabinoside. Blut 28:299, 1974.
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III. 定義および原理

P.23 掲載の参考文献
1) Melamed, M. R., et al (eds) :Flow cytometry and sorting, John Wiley and Sons. Inc., New York, 1979.
 
2) 太田和雄・他:Flow cytometry(FCM)の癌臨床への応用. 癌と化学療法 9:1140, 1982.
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3) 野口義夫:種々のフロー・サイトメーターの現状についての調査. 電子技術総合研究所彙報 44:160, 1980.
 
4) Van Dilla, N. A., et al:Cell microfluorometry:a method for rapid fluorescence measurement. Science 163:1213, 1969.
 
5) Crissman, H. A., et al:Cell cycle analysis in 20 minutes. Science 184:1297, 1974.
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6) Herzenberg, L. A., et al:Analysis and separation using the fluorescence activated cell sorter(FACS) in Handbook of Experimental Immunology. Weir, D. M. (ed.) pp.22. 1, Blackwell Scientific pub., Oxford, 1978.
 
7) Davies, K. E., et al:Cloning of a representative genomic library of the human X chromosome after sorting by flow cytometry. Nature 293:374, 1981.
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8) 御供泰治・他:DNA瞬間自動測定装置およびその応用. 医学のあゆみ 97:863, 1976.
 
9) 太田和雄・他:DNA瞬間自動測定装置. 癌と化学療法 4:179, 1977.
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10) Trujillo, T. T., et al:Adaptation of the fluorescent feulgen reaction to cells in suspension for flow microfluorometry. Acta Cytologica. 16:26, 1972.
PubMed
11) Yataganas, X., et al:Evaluation of a Feulgen type reaction in suspension using flow-microfluorimetry and a cell separation technique. Acta Cytologica. 19:71, 1975.
 
12) Gohde, W., et al:Simultane Impulsfluorimetrie des DNS-und Proteingehaltes von Tumorzellen, Z. Anal. Chem. 252:328, 1970.
 
13) Buchner, T., et al:Dielmpuls cytophotometrie in der hamatologischen Cytologie. Klin. Wochenschr. 49:1090, 1971.
 
14) Herzenberg L. A., et al:Fluorescence-activated cell sorting. Sci. Am. 234:108, 1976.
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15) Wheeless, L. L., et al:Slit-scan flow system for automated cytopathology. Acta Cytologica. 19:45, 1975.
 
16) Dean, P. (Lawrence Livermore 研究所, C.A., U.S.A) :私信
 
17) Salzman, G. C., et al:Cell classification by laser light scattering:Identification and separation of unstained leukocytes. Acta Cytologica. 19:374, 1975.
 
18) Moldavan, A.:Photo-electric technique for the counting of microscopical cells. Science 80:188, 1934.
 
19) Crossland-Taylor, P. J.:A device for counting small particles suspended in a fluid through a tube. Nature 171:37, 1953.
 
20) Reynolds, O.:An experimental investigation of the circumstances which determine whether the motion of water shall be direct or sinuous, and of the law of resistance in channels. Phil. Trans. 935, 1883.
 
21) Andreeff, M., et al:Cellular ras oncogene expression and cell cycle measured by flow cytometry in hematopoietic cell lines. Blood 67:676, 1986.
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22) 野口義夫:装置の構造と機能, フローサイトメトリーハンドブック, 天神美夫・他編, pp.43. サイエンスフォーラム, 東京, 1984.
 

IV. 試料作製法

P.36 掲載の参考文献
1) 辻 公美・他(分担執筆) :第5部, 免疫細胞, 免疫実験操作A:426, 日本免疫学会編, 1975.
 
2) 加納康彦・他(分担執筆) :血液細胞の分離. 臨床病理 44:55, 1981.
 
3) Krishan, A.:Rapid flow cytofluorometric analysis of mammalian cell cycle by propidium iodide staining. J. Cell Biol. 66:188, 1975.
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4) Boyum, A.:Separation of leukocytes from blood and bone marrow. Scand. J. Clin. Lab. Invest. 21(Suppl.) :97, 1968.
 
5) Pertoft, H., et al:Separation of human monocytes on density gradients of percoll. J. Immunol. Methods, 33:221, 1980.
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6) 高本 滋・他:Percoll gradientによる血液細胞分離の試み -FCM分析を含めて-. 日本血液学会雑誌 46:489, 1983.
 
7) Andreeff, M.:私信
 
8) 山中 学:血液凝固C:血小板機能, 新版, 日本血液学全書 13:415, 丸善, 東京, 1979.
 
9) Tanke, H. J., et al:Flow cytometry of human reticulocytes based on RNA fluorescence. Cytometry 1:313, 1980.
 
10) Mendelsohn, M. L., et al:The detection and sorting of rare sickle hemoglobin containing cells in normal human blood. In:Flow Cytometry IV, Laerum, O. D. et al. (eds). Universitetsforlaget, Bergen-Oslo-Trondheim, 1980.
 
P.44 掲載の参考文献
1) 杉田道夫・他:核DNA分析における新しい組織分散法の応用. 癌の臨床 28:15 30, 1982.
 
2) Hoshino, T., et al:Differencies in brain nuclear DNA as determined by flow cytometry. Neurol. Med. Chir. 17:87, 1977.
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3) Hoshino, T., et al:Flow cytometry of isolated nuclei prepared from 9L rat brain tumor. Lab. Inv. 41:72, 1972.
 
4) 野村和弘:組織培養法 d) 脳. 代謝 12:1071, 1975.
 
5) Pallavicini, M. G., et al:Solid KHL tumor dispersal for flow cytometric cell kinetic analysis. Cytometry 2:54, 1981.
 
6) Pfitzer, P., et al.:Flow cytometry of human testicular tissue. Cytometry 3:116, 1982.
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7) Madden, R. E., et al:Production of viable single cell suspension from solid tumors. J. Natl. Cancer Inst. 27:841, 1961.
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8) Hoshino, T., et al:Clonogenicity of multiple populations of human glioma cells in vitro sorted by DNA content. Cancer 50:997, 1982.
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9) Taylor, I. W.:A rapid single step staining technique for DNA analysis by flow microfluorimetry. J. Histochem. Cytochem. 28:102, 1980.
 
P.50 掲載の参考文献
1) Hedley, D. W., et al:Method for analysis of cellular DNA content of paraffin embedded pathological material using flow cytometry. J. Histochem. Cytochem. 31:1333, 1983.
PubMed
2) Hosaka, Y., et al:Pheochromocytoma:Nuclear deoxyribonucleic acid patterns studied by now cytometry. Surgery 100:1003, 1986.
 
3) Vindelov, L. L., et al:Adetergent-trypsin method for the preparation of nuclei for flow cytometric DNA analysis. Cytometry, 3:323, 1983.
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4) Stephenson, R. A., et al:Effect of section thickness on quality of flow cytometric DNA content determinations in paraffin-embedded tissues. Cytometry 7:41, 1986.
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P.57 掲載の参考文献
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2) 野口義夫:フローサイトメトリーの基礎理論. フローサイトメトリーハンドブック (天神美夫他編) p60-87, サイエンスフォーラム, 1984.
 
3) 御橋広真:螢光法で何がわかるか. 蛍光測定 生物科学への応用(木下一彦他編) p.1-44, 学会出版センター, 1982.
 
4) Waggoner, A. S.:Fluorescent probes for analysis of cell structure, function, and health by flow and imaging cytometry. in Applications of Fluorescence in the Biomedical Sciences (Taylor DL, et al. eds.) p.3-28, Alan R Liss, Inc., 1986,
 
5) Gill, J. E.:Principles of cytochemistry. in Flow cytometry and sorting. (Melamed, M. R, Mullaney, P. F. and Mendelsohn, M. L. ed.) p233-242, John Wiley and Sons Inc., 1979.
 
6) Aubin, J. E.:Autofluorescence of viable cultured mammalian cells. J. Histochem Cytochem. 27:36-43, 1979.
 
7) Weil, J. G. and Chused, T. M.:Eosinophil autofluorescence and its use in isolation and analysis of human eosinophils using flow microfluorometry. Blood 57:1099-1104, 1981.
 
8) Feller, M. J., Chen, A. S., Mont, M., et al:Patterns and intensity of autofluorescence and its relation to melanin in human epidermis and hair. Int. J. Dermatol. 18:722-730, 1979.
 
9) Trask, B., et al:Detection of DNA fluorescence in nuclei in suspension by in situ hybridization and dual beam flow cytometry. Science 230 :1404-1403, 1985.
 
P.73 掲載の参考文献
1) Hudson, B, et al:The use of ethidium bromide analogue in the dye-buoyant density procedure for the isoration of closed circular DNA:The variation of the superherix density of mitochondrial DNA. Proc. Natl. Acad. Sci. USA. 62:813, 1969.
 
2) Lepecq, J. B.:Use of ethidium bromide for separation and determination of various conformational forms and measurement of their associated enzymes. Method of Biochemical Analysis, Edited by D Glick. vol 20, Interscience Publishers, New York, 1971, pp.41-86.
 
3) Gohde, W. et al:Simultane Impulsefluorimetrie das DNA-und Proteingehaltes von Tumorzellen. Z. Aal. Chem. 251:328, 1970.
 
4) Protocol #16 Cellular DNA content, RNA removal by Ba(OH)2, Bio/Physics, System, Inc. Bald Win Place Road, Mahopac, New York, 10541.
 
5) Crissman, H. A. et al:Technique for quantitative staining of cellular DNA for flow cytometric analysis. Flow Cytometry and Sorting. Edited by Melamed MR et al:Wiley Medical Publishers, New York, pp.243-261, 1979.
 
6) Vindelov, L. L. et al:Flow microfluorometric analysis of nuclear DNA in cells from solid tumors and cell suspensions. Virchows. Arch. Cell Pathol. 23:227, 197
 
7) Krishan, H. A.:Rapid flow cytometric analysis of mammalian cell cycle by propidium iodide staining. J. Cell. Biol. 66:188, 1975.
 
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9) Crissman, H. A. et al:Rapid staining method for analysis 0f deoxyribonucleic acid and protein in mammalian cells. J. Histochem. Cytochem. 24:64, 1976.
 
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11) Arndt-Jovin, D. J. et al:Analysis and sorting of living cells according to deoxyribonucleic acid content. Cancer 50:997, 1982.
 
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15) Latt, S. A.:Microfluometric detection of deoxyribonucleic acid in human meta-phse chromosomes. Proc. Natl. Acad. Sci. USA. 70:3395, 1973.
 
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17) Perry, P. et al:New giemsa method for the differential staining of sister chromatids. Nature 251:156, 1974.
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P.81 掲載の参考文献
1) Darzynkiewicz, Z.:Acridine orange as a molecular probe in studies of nucleic acid in situ. Flow cytometry and Sorting. John Wiley, New York:285, 1979.
 
2) Darzynkiewicz, Z., et al.:New cell cycle compartments identified by multiparameter flow cytometry. Cytometry 1(2) :98, 1980.
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3) Shapiro, H. M.:Flow cytometric estimation of DNA and RNA content in intact cells stained with hoechst33342 and pyronin Y. Cytometry 2(3) :143, 1981.
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5) Pollack, A., et al.:Flow cytometric analysis of RNA content in different cell population using pyronin Y and methyl green. Cytometry 3(1) :28, 1982.
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7) Nicolini, C., et al.:Mass action and acridine orange staining. Static and flow cytometry. J. Histochem. Cytochem. 27(1) :102, 1979.
 
8) Darzynkiewicz, Z., et al.:Application of pyronin Y(G) in cytochemistry of nucleic acid. Cytometry 8(2) :138, 1987.
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9) Darzynkiewicz, Z., et al.:Cell cycle-specific effects of tumor necrosis factor. Cancer Res. 44:83, 1984.
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10) Wallen, C. A., et al.:Comparison of two flow cytometric assays for cellular RNA-Acridine orange and propidum iodide. Cytometry 3(3) :155, 1982.
 
11) Tanke, H. J., et al.:Flow cytometry of human reticulocytes based on RNA fluorescence. Cytometry 1(5) :313, 1980.
 
12) Darzynkiewicz, Z., et al.:Cytostatic and cytotoxic properties of pyronin Y. Relation to mitochondrial localization of the dye and interaction with RNA. Cancer Res. 46:5760, 1986.
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13) Pennings, A., et al.:Improved flow cytometry of cellular DNA and RNA by on-line reagent addition. Cytometry 8(3) :335, 1987.
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P.94 掲載の参考文献
1) Pearse, A. G. E.:Histochemistry, Theoretical and Applied, 3rd ed., vol.2, Williams and Wilkins, Baltimore, 1186, 1972.
 
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3) Rigler, R. Jr.:Microfluorometric characterization of intracellular nucleic acids and nucleoproteins by acridine orange. Acta. Physiol. Scand. 67(suppl.) :267, 1966.
 
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5) Darzynkiewicz, Z, et al:Conformation of RNA in situ as studied by acridine orange staining and automated cytofluorometry. Exp.Cell Res. 95:143, 1975.
PubMed
6) Traganos, F., et al:Simultaneous staining of ribonucleic and deoxyribonucleic acids in unfixed cells using acridine orange in a flow cytofluorometric system. J. Histochem. Cytochem 25:46, 1977.
 
7) Piwnicka, M., et al:RNA and DNA content of isolated cell nuclei measured by multiparameter flow cytometry. Cytometry 3:269, 1983.
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8) Melamed, M. R., et al:Acridine orange as a quantitative cytochemical probe for flow cytometry. Histochemistry:The Widening Horizons, John Wiley & Sons, 237, 1981.
 
9) Darzynkiewicz, Z., et al:New cell cycle compartments identified by multiparameter flow cytometry. Cytometry 1:98, 1980.
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10) Darzynkiewicz, Z., et al:Different sensitivity of DNA in situ in interphase and metaphase chromatin to heat denaturation. J. Cell Biol. 73:128, 1977.
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11) Darzynkiewicz, Z, et al:Interphase and metaphase chromatin. Different stain ability of DNA with acridine orange after treatment at low pH. Exp.Cell Res. 110:201, 1977.
 
12) Narin, R. C.:Fluorescent Protein Tracing 3rd ed. Williams & Wilkins, Baltimore, 503, 1969.
 
13) Freeman, D. A., et al:Evaluation of six fluorescent protein stains for use inflow microfluorometrry. Stain Technol. 50:279, 1975.
 
14) Crissman, H. A., et al:Rapid staining methods for analysis of deoxyribonucleic acid and protein in mammalian cells. J. Histochem. Cytochem. 24:64, 1976.
 
15) Steinkamp, J. A., et al:Automated analysis of Deoxyribonucleic acid, protein and nuclear to cytoplasmic relationships in tumor cells and gynecologic specimens. J. Histochem. Cytochem. 22:616, 1974.
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16) 西谷 巌・他:Flow cytometry-Computer連動による子宮癌細胞のMultiparameter解析 癌と化学療法 9:1164, 1982.
 
P.111 掲載の参考文献
1) Gratzner, H. G.:Monoclonal antibody to 5-bromo-and 5-iododeoxyuridine:a new reagent for detection of DNA replication. Science 218:474, 1982.
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2) Kohler, G., et al:Continuous cultures of fused cells secreating antibody of predefined specificity. Nature 256:495, 1975.
 
3) Dolbeare, F., et al:Flow cytometric measurement of total DNA content and incorporated bromodeoxyuridine. Proc. Natl. Acad. Sci. USA. 80:5573, 1983.
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4) Vandalaan, M., et al:Improved high-affinity monoclonal antibody to iododeoxyuridine. Cytometry 7:499, 1986.
 
5) Gonchoroff, N. J., et al:Amonoclonal antibody reactive with 5-bromo-2-deoxyuridine that does not requrie DNA denaturation. Cytometry 6:506, 1985.
 
6) Nagashima, T., et al:Rapid detection of S-phase cells by anti-bromodeoxy uridine monoclonal antibody in 9L brain tumor cells in vitro and in situ. Acta. NeuroPathol 66:12, 1985.
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7) Hoshino, T., et al:Cell kinetic studies of in situ human brain tumors with bromodeoxyuridine. Cytometry 6:627, 1985.
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8) 佐々木功典・他:モノクローナル抗BrdU抗体を利用した人癌組織の標識率測定法. 病理と臨床 3:565, 1985.
 
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10) Moran, R., et al:Detection of 5-bromodeoxyuridine(BrdUrd) incorporation by monoclonal antibodies:Role of the DNA denaturation step.J. Histochem Cytochem 33:821, 1985.
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11) Dolbeare, F., et al:Use of restriction enzymes and exonuclease III to expose BrdUrd in DNA for immunochemical assay. Cell Tissue Kinet. 20:248, 1987.
 
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2) 杉田道夫・他:FCM (flow cytometry) によるDNAパターンからみたcisplatin療法の効果判定. 最新医学 39(8) :1719-1721, 1984.
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4) 天神美夫・他:Flow cytometry からみた子宮頸癌の細胞像. 最新医学 40(1) :126-129, 1985.
 
5) Jones, K. H., et al:An Improved Method to Determine Cell Viability by Simultaneous Staining with Fluoresein Diacetate-Propidium Iodide. J. Histochem. Cytochem. 33(1) :77-79, 1985.
 
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11) Kvach, J. T., et al:A Fluorescent Staining Procedure for Determining the Viability of Mycobacterial cells. Int. J. Lepr. 50(2) :183-192. 1982.
 
12) Jarnagin, J. L., et al:The Use of Fluorescein Diacetate and Ethidium Bromide as a Stain for Evaluating Viability of Mycobacteria. Stain Technol. 55(4) :253-258, 1980.
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13) 本間滋・他:Fluorescein Diacetate-Propidium Iodide 複合螢光染色による絨毛細胞の生死の判別法. 日産婦誌 38(11) :2089-2090, 1986.
 
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8) Pallavicini, M. G. et al:Cell cycle distribution of chronically hypoxic cells and determination of the clonogenic potential of cells accumlated in G2+ M phases after irradiation of a solid tumor in vivo. Cancer Res. 39:1891, 1979.
 
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13) 高本 滋・他:FCMによる腫瘍マーカーとしての異数倍数体の検索, -第一報, 標準試料について-. 日血会誌 47:308, 1984.
 
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VI. セル・ソーティング

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VII. 応用

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4) Karavodin LM, et al:T lymphocyte subsets in patients with malignant melan-oma. Cancer. Immunol. Immunother. 11:251, 1981.
 
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8) McCluskey DR, et al:T lymphocyte subsets in the peripheral blood of patients with benign and malignant breast disease. Brit. J. Cancer 47:307, 1983
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10) Reinherz EL, et al:Regulation of the immune response-inducer and suppressor T lymphocyte subsets in human being. N. Eng. J. Med. 303:370, 1980.
 
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12) 渡辺 卓・他:胃癌患者における末梢血リンパ球サブセットの解析. 日本癌学会総会記事:147, 1983,
 
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2) Landy, A., et al:Characterization of a phenotypically distinct subpopulation of Leu-2+ cells that suppresses T cell proliferative responses. J. Immunol. 131:2757, 1983.
 
3) Clement, L. T., et al:Morphologic and phenotypic features of the subpopulation of Leu-2+ cells that suppresses B cell differentiation. J. Immunol. 133:2461, 1984.
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4) Clement, L. T., et al:Characterization of human lymphocyte subpopulations:Alloreactive cytotoxic T-lymphocyte precursor and effector cells are phenotypically distinct from Leu2+ suppressor cells. J. Clin. Immunol. 4:395, 1984.
 
5) Gatenby, P. A., et al:Dissection of immunoregulatory subpopulations of T lymphocytes within the helper and suppressor sublineages in man. J. Immunol. 129:1997, 1982.
 
6) Damle, N K., et al:Soluble antigen-primed inducer T cells activate antigen-specific suppressor T cells in the absence of antigenpulsed accessory cells:phenotypic definition of suppressor-inducer and suppressor-effector cells. J. Immunol. 132:644, 1984.
 
7) Morimoto, C., et al:The isolation and characterization of the human suppressor inducer T cell subset. J. Immunol. 134:1508, 1985.
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8) Evans, R. L., et al:Peripheral human T cells sensitized in mixed Ieukocyte culture synthesize and express Ia-like antigens. J. Exp.Med. 148:1440, 1978.
 
9) Yu, D. T. Y., et al:Peripheral blood Ia-positive T cells. J. Exp.Med. 151:91, 1980.
 
10) Abo, T., et al:Differentiation stages of human natural killer cells in lymphoid tissues from fetal to adult life. J. Exp.Med. 157:273, 1983.
 
11) 安保 徹:モノクローナル抗体を用いたヒトNK細胞の解析. 最新医学 39:51, 1984.
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2) Morimoto, C., et al.:Alterations in immunoregulatory T cell subsets in active systemic lupus erythematosus. J. Clin. Invest. 66:1171, 1980.
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3) Smolen, J. S., et al.:Systemic lupus erythematosus:delineation of subpopulations by clinical, serologic, and T cell subset analysis. American J. Medical Sciences. 289:139, 1985.
 
4) Morimoto, C., et al.:Relationship between systemic lupus erythematosus T cell subsets, anti-T cell antibodies, and T cell functions. J. Clin. Invest. 73:689, 1984.
 
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6) 高井修・他:SLE-B細胞におけるDR抗原表現の異常. 臨床免疫19(Suppl. 11), 227, 1987.
 
7) 江口勝美・他:RA患者の免疫学検討(第4報)-RA患者滑液中のT細胞サブセットについての検討-. 九州リウマチ 6:144, 1987.
 
8) Goto, M., et al.:T cytotoxic and helper cells are markedly increased, and T suppressor and inducer cells are markedly decreased, in rheumatoid synovial fluids:Arthritis Rheum. 30:737, 1987.
 
9) Emery, P., et al.:Deficiency of the suppressor inducer subset of T lymphocytes in rheumatoid arthritis. Arthritis Rheum. 30:849, 1987.
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10) 下村周子・他:RA患者末梢血及び関節液中の単球マクロファージにおけるla抗原の表現に関する検討. 第29回日本リウマチ学会総会(福岡), 1985年5月9, 10日.
 
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12) 西岡久寿樹・他:慢性関節リウマチの病態-関節内免疫応答の解析を中心に-. Medical Immunology. 13:265, 1987.
 
13) 沢井高志・他:慢性関節リウマチの病理, 病態-最近の進歩から-. Medical Immunology 13:747, 1987.
 
14) Masuyama, J., et al.:Mechanisms of lymphocyte adhesion to human vascular endothelial cells in culture. T lymphocyte adhesion to endothelial cells through endothelial HLA-DR antigens induced by gamma interferon. J. Clin. Invest. 77:1596, 1986.
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15) 江口勝美・他:自己抗体の多様性と臨床的意義-臓器特異的自己免疫疾患-. Medical Immunology. 14:767, 1987.
 
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18) Ludgate, M. E., et al.:Analysis of T cell subsets in Gravesdisease:alternations associated with carbimazole. British Medical J. 288:526, 1984.
 
19) Chan, J. Y. C., et al.:Activated (Ia+) T-lymphocytes and their subsets in autoimmune thyroid disease:analysis by dual laser flow microfluorocytometry. J. Clin. Endocrinol. Metab. 62:403, 1986.
 
20) Hafler, D. A., et al.:Antigen reactive memory T cells are defined by Tal. J. Immunol. 137:414, 1986.
 
21) Margolick, J. B., et al.:Immunohistochemical characterization of intrathyroid lymphocytes in Gravesdisease:interstitial and intraepithelial populations. Amer. J. Med. 76:815, 1984.
 
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23) Bene, M. C., et al.:Graves' disease:in situ localization of lymphoid T cell subpopulations. Clin. Exp. Immunol. 52:311, 1983.
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24) Jansson, R., et al.:Intrathyroidal HLA-DR expression and T lymphocyte phenotypes in Graves' thyrotoxicosis, Hashimoto's thyroiditis and nodular colloid goiter. Clin Exp Immunol. 58:264, 1984.
 
25) Ueki, Y., et al.:Dysfunction of suppressor T cells in thyroid glands from patients with Gravesdisease. J. Clin. Endocrinol. Metab. 65:922, 1987.
 
26) Tezuka, H., et al.:Natural killer and natural killer-like cell activity of peripheral blood and intrathyroidal mononuclear cells from patients with Gravesdisease. J. Clin. Endocrinol. Metab. 66:1988. (in press)
 
27) Selmaj, K., et al.:Multiple sclerosis:increased expression of interleukin-2receptors on lymphocytes. Neurology 36:1392, 1986.
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28) 中尾英人・他:多発性硬化症の臨床経過に伴う活性化T細胞, Tal陽性細胞の変動とその意義. 医学のあゆみ 143:107, 1987.
 
29) Matsunaga, M. et al.:Class II major histocompatibility complex antigen expression and cellular interactions in thyroid glands of Gravesdisease. J. Clin. Endocrinol. Metab. 62:723, 1986.
 
30) 江口勝美・他:バセドウ病における甲状腺濾胞細胞のクラス II MHC抗原の発現意義について. ホルモンと臨床 35:57, 1987.
 
31) 江口勝美・他:Graves病における免疫学的検討-特に甲状腺組織内における細胞間相互作用について. 臨床免疫 19(Suppl. 11) :265, 1987.
 
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3) 玉川重徳・他:第61回日本感染症学会, 報告 1987. 4. 2-3.
 
4) McDougal, J. S., et al:Binding of HTLV-111/LAV to T 4 t cells by a complex of the 110 K viral protein and the t4 molecul. Science 231:382, 1986.
 
5) Dalgleish, A. G., et al:The CD4 antigen in an essential component of the receptor for the AIDS retrovirus. Nature 312:763, 1984.
 
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2) Grim, E. A., Mazunder, A., et al:Lymphokine activated killer cell phenomenon II :J. Exp.Med. 157:884, 1983.
 
3) Itho, K., Tilden, K. B. and Black, C. H.:Lysis of human solid tumor cell by lymphokine activated killer cells. J. Immunol. 136:3910, 1986.
 
4) 蟹沢祐司, 高後裕, 笹川 裕・他:cell sorterを用いて分取したIL-2 activated killer細胞の多様性. 医学のあゆみ 140(3) :165, 1987.
 
5) 古江 尚:インターフェロンの投与法と副作用-生体内動態からみて. 癌と化学療法 11:186, 1984.
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8) 小川一誠, 高久史麿・他:遺伝子組換えインターフェロンγのphase I study. 癌と化学療法 14(2) :446, 1987.
 
9) 原口惣一, 小出幸夫・他:組換えインターフェロンα-2bによるin vitro抗腫瘍活性の多面的検討. 癌と化学療法 13(11) :3326, 1986.
 
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11) Uchida, A. and Mickshe, M.:In vivo augmentation of natural killer activity by OK-432. Intern. J. Immunopharm. 3:365, 1981.
 
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13) 仁尾義則, 土谷利晴・他:胃癌における末梢血, 脾静脈血, 腸間膜リンパ節のリンパ球subsetとNK活性およびOK-432経口投与によるそれらの変動. 消化器と免疫 15:29, 1985.
 
14) 松永謙一, 森田伊津子・他::X5563担癌マウスにおける免疫能の変動とPSKの効果. 癌と化学療法 13(2) :3453, 1986.
 
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8) Otto, F. J., Oldiges, H., G6hde, W., Barlogie, B., Schumann, J.:Flow cytogenetics of uncloned and cloned chinese hamster. Cytogenet. Cell. Genet. 27:52, 1980.
 
9) Blumenthal, A. B., Dieden, J. D., Kapp, L. N. and Sedat, J. W.:Rapid isolationof metaphase chromosomes containing high molecular weight DNA. J. Cell Biology. 81:255, 1979.
 
10) Kuo, M. T.:Comparison of chromosomal structures isolated under differentconditions. Exp.Cell Res. 138:221, 1982.
 
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12) Bijman, J. Th.:Optimization of mammalian chromosome suspension preparations employed in a flow cytometric analysis. Cytometry 3:354, 1983.
 
13) Carrano, A. V., Gray, J. W., Moore, D. H., Minklev, J. L., Mayall, B. H., Van Dilla M. A. and Mendelsohn, M. L.:Purification of the chromosomes of the indian muntjac by flow sorting. J. Histochom. Cytochem. 24:348, 1976.
 
14) Lebo, R. V., Carrano, A. V., Burkhart-Schultz, K., Dozy, A., Yu, L. G. and Kan, Y. W.:Assignment of humanβ-, γ- and δ-globin genes to the short arm of chromosome 11 by chromosome sorting and DNA restriction enzyme analysis. Proc. Natl. Acad. Sci. U.S.A. 75:5804, 1979.
 
15) Yu, L C., Aten. J., Gray, J. and Carrano, A. V.:Human chromosome isolationfrom short-term lymphocyte culture for flow cytometry. Nature 293:154, 1981.
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17) Davies, K. E., Young. B. D., Elles, R. G., Hill, M. E. and Williamson, R. (1981) :Cloning of a representative genomic library of the human X-chromosomeafter sorting by flow cytometry. Nature 293:374, 1981.
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18) Lebo, R. V., Bastian, A. M.:Design and operation of a duel laser chromosomesorter. Cytometry 3:213, 1983. Cremer, C. and Gray, J. W.:Replication kinetics of chinese hamster chromosomes as revealed by bivariate flow karyotyping. Cytometry 3:282, 1983.
 
19) Horan, P. K. and Wheeless, L. L.:Quantitative single cell analysis and sorting. Science 198:149, 1977.
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20) Krumlauf, R., Jeanpierre, M., Young, B. D.:Construction and chracterizationof genomic libraries from specific human chromosomes. Proc. Natl. Acad. Sci. U.S.A. 79:2971, 1982.
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21) Kunkel, L. M., Tantravahi, U., Eisenhard, M. and Latt, S. A.:Regional localization on the human X of DNA segments cloned from flow sorted chromosomes. Nucleic Acid. Res. 10:1557, 1982.
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22) Murray, J. M., Davies, K. E., Harper, P. S., Harper, P. S., Meredith, L, Mueller, C. R. and Williamson, R.:Linkage relationship of a cloned DNA sequence or the short arm of the X chromosome to Ducheme muscular dystrophy. Nature 300:69, 1982.
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23) Disteche, C. M., Carrano, A. V., Ashworth, L. K., Burkhart-Schultz, K. and Latt, S. A.:Flow sorting of the mouse Cattanach X chromosome, T(X;7) 1Ct, in an active or inactive. state. Cytogenet. Cell. Genet. 29:189, 1981.
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24) Disteche, C. M., Kunkel, L, M., Lojewski, A., Orkin, S. H., Eisenhard, M., Sahar E., Travis, B. and Latt, S. A.:Isolation of mouse X-chromosome specific DNA from X-enriched lambda phage library derived from Flow sorted chromosomes. Cytometrpt 2:282, 1982.
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25) 貞包雄次郎, 渡辺武:Flow cytometry法によるヒト染色体のhigh resolution analysisおよびsorting. 医学のあゆみ 125:1006, 1983.
 
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1) Kavathas, P. and Herzenberg, L. A.:Proc. Natl. Acad. Sci. USA. 81:7688-7692, 1983.
 
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7) Hsu, C., Kavathas, P. and Herzenberg, L. A.:Natare 312:68, 1984.
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8) Seed, B. and Aruffo, A.:Proc. Natl. Acad. Sci. USA. 84:3365-3369, 1987.
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11) Nolan, G. P., Fiering, S., Nicolas, J. F. and Herzenberg, L. A.:Proc. Natl. Acad. Sci. USA. (in Press).
 
12) Guinta, D. R. and Korn, L. J.:Mol. Cell. Biol. 6:2536-2542, 1986.
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13) Gilbert, D. M.:Proc. Natl. Aced. Sci. USA. 83:2924-2928, 1986.
 
P.575 掲載の参考文献
1) Hoshino, T., et al:The distribution of nuclear DNA from human brain tumor cells:Flow cytometric studies. J. Neurosurg. 49:13, 1978.
 
2) Hoshino, T., et al:Clonogenicity of multiple populations of human glioma cells in vitro sorted by DNA content. Cancer 50:997, 1982.
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3) Kobayashi, S., et al:Variable response to BCNU of human glioma cells sorted according to DNA content. J. Neuro-Oncol. 2:5, 1984.
 
4) 小林 秀・他:ヒトglioma細胞亜群の分離とその継代株の検討-コロニー形成能とBCNU感受性試験. 脳と神経 37:707, 1985.
 
5) Gray, J. W.:Flow cytometry and cell kineties:relation to cancer therapy. ln:Laerum et al(eds.), Flow Cytometry IV, Oslo:Universitetsforlaget, p.485, 1980.
 
6) Gray, J. W., et al:Rapid cell cycle analysis II. Phase duration and dispersion from computer analysis of RC curves. Cell Tissue Kinet. 16:457, 1983.
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7) Pallavicini, M. G., et al:Quanititative analysis of the cytokinetic response of KHT tumors in vivo to 1-D-arabinofuranosylcytosine. Cancer Res. 42:3125, 1982.
 
8) Rice, G. C., et al:An ultra-pure in vitro synchrony method employing centrifugal elutriation and viable flow cytometric cell sortillg. Cytometry 5:289, 1984.
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9) Freyer, J. P., et al:Coulter volume cell sorting to improve the precision of radiation survival assays. Radiat. Res. 97:608, 1984.
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10) Freyer, J. P., et al:Viable sorting of intact multicellular spheroids by flowcytometry. Cpttometry 8:427, 1987.
 
11) Durand, R. E.:Oxygen enhancement ratio in V79 spheroids. Radiat. Res. 96:322, 1983.
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12) Durand, R. E.:Use of a cell sorter for assays of cell clonogenicity. Cancer Res. 46:2775, 1986.
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1) Kreisberg, J. I., et al:Separation of proximal tubule cells from suspensions of rat kidney cells in density gradients of ficoll in tissue culture medium. Am. J. Pathol. 86:590, 1977.
 
2) Jones, D. P, et al:Use of isolated kidlley cells for study of drug metabolism. Biochem. Pharmacol. 28:929, 1979.
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3) Heidrich, H. G., et al:Homogeneous cell populations from rabbit kidney cortex Proximal, distal tubule, and renin-active cell isolated by free-now electrophoresis. J. Cell Biol. 74:780, 1977.
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4) Thimmappayya, B. et al:Preparation of kidney cell suspensions and respiration of kidney and liver cell suspensions. Exp.Cell Res. 63:333, 1970
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5) Nagineni, C. N, et al:Isolation of cells from rabbit renal proximal tubules by using a hyperosmolar intracellular-like solution. Biochem. J. 223:353, 1984.
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6) Berry, M. N., et al:High-yield preparation of isolated rat liver parenchymal cells. J. Cell Biol. 43:506, 1969.
 
7) Roser, B., et al:The distribution of intravenously injected Kupffer cells in the mouse. J. Reticuloendothelial. Soc. 5:455, 1968.
 
8) Mills, D. M., et al:Electron microscopic study of isolated Kupffer cells. Am. J. Pathol. 54:147, 1969.
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9) Knok, D. L., et al:Separation of Kupffer and endothelial cells of the rat liver by centrifugal elutriation. Exp.Cell Ret. 99:444, 1976.
 
10) Endou, H. et al:Use of a flow cytometer for the separarion of isolated kidney cells. Biochemistry of Kidney Function(Ed. by Morel F.), Elsevier North-Holland Biomedical Press pp.69, 1982.
 
11) Endou, H.:Cytochrome P450 monooxygenase system in the rabbit kidney;its intranephron localization and its induction. Jpn. J. Pharmacol. 33:423, 1983.
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12) Kohler, G., et al:Continuous cultures of fused cells secreting antibody of predefined specificity. Nature 256:496, 1975.
 
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14) Koseki, C., et al:Intercalated cells of rabbit kidney:Their isolation by monoclonal antibody and characterization. Kidney Int. 33:in press, 1988.
 
15) 北条一夫・他:Cell sorter(Flow cytometer) を利用したKupffer細胞の単離とその特性. Acta Hepat. Jpn. 23:864, 1982.
 
16) Gumucio, J. J., et al:Transport of fluorescent compounds into hepatocytes and the resultant zonal labeling of the hepatic acinus in the rat. Gastroenterology 30:639, 1981.
 
17) 筋野甫・他:単離ラット肝実質細胞の亜分画に関する研究. Acta Hepat. Jpn. 25:1433, 1984.
 
18) 遠藤仁・他:肝小葉中心部並びに周辺部細胞の分取とP450局在の特異性. 第68回日本薬理学会関東部会講演要旨 p.33, 1983.
 
P.605 掲載の参考文献
1) Sandritter, W., et al:Zur Krebs Diagnostik an Vaginalen Zellausstrichen mittels Cytophotometry Messungen. Arch. Gynnnecol. 19:293, 1960.
 
2) 西谷巌・他:子宮癌細胞の計量診断と蛍光顕微分光測光法. 産婦治療 33:98, 1976.
 
3) 下斗米啓介・他:Information zur Kerntechnik, Nrl, 18, 1975.
 
4) 井筒俊彦:子宮頸癌検診の再編成. 第31回日産婦学会北日本連合地方部会特別講演要旨 40, 1983.
 
5) Melamed, M. R., et al:Flow cytometry and sorting, 1st Ed. 351, John Wiley&Sohns, New York, 1979.
 
6) 西谷巌:細胞群の選別・解析とその臨床応用. 臨床婦産 34:169, 1980.
 
7) 西谷巌・他:細胞機能解析コンピューターの臨床における工夫と実践. 臨床婦産 36:316, 1982.
 
8) Soost, H. J., et al:Comparison of Papanicolaou staining and Feulgen stainingfor automated presceening. J. Analytical & Quantitative Cytol. 5:61, 1983.
 
9) Fowlkes, B. J, et al:Flow microfluorometric system for screening gynecologiccytology specimens using propidium iodide-fluorescein isothiocyanate. J. Histochem. Cytochem. 24:332, 1976.
 
10) Iwao Nishiya, Yoshiaki Ishizaki, Keisuke Shimotomai, Ichiro Sawamura, Kohichi Tamura and Masayoshi Akama:Microspectrophotometric screening system withmulti-fiber scanning, practically feasible for detection of premaligmant and malignant lesions of the cervix. Proc. Japan Acad. 56:73, 1980.
 
P.616 掲載の参考文献
1) Barlogie, B., et al:Cellular DNA content as a marker of neoplasia in man. Jon. Medicine 69:195, 1980.
 
2) Crissman, H. A., et al:Rapid simultaneous measurement of DNA, protein andcell volumes in single cells from large mammalian cell populations. J. Cell Biol. 59:766, 1973.
 
3) Crissman, H. A., et al:Rapid staining methods for analysis of deoxyribonucleicacid and protein in mammalian cells. J. Histochem. and Cytochem. 24:64, 1976.
 
4) 山田憲夫:原発性肺癌のDNA-RNAを指標とした悪性度評価の試み -特にFlow Cytometryを応用して-. J. Jpn. Soc. Cancer Ther. 22:2252, 1987.
 
5) Bunn, P. A., et al:Diagnostic alld biological implications of flow cytometric DNA content analysis in lung cancer. Cancer Res. 43:5026, 1983.
 
6) Teodori, L., et al:Non-small cell lung carcinoma:Tumor characterizationon the basis of flow cytometrically determined cellular heterogeneity. Cytology 4:174, 1983.
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P.634 掲載の参考文献
1) 野田起一郎:子宮頸部上皮の癌化防止に関する研究. 日産婦誌 27(3) :735, 1975.
 
2) 岸上義彦・他:自動スクリーニングに通した膣スミアの作成法, 特に好中球の除去について. 日臨細胞誌 20(3) :523-531, 1981.
 
3) 阪口耀子・他:Flow-cytometryのための組織細胞分散法の確立. 日臨細胞誌 22(2) :228-234, 1983.
 
4) K. Goerttler., et al:Highlighting of progress by Research Groups in cytology Automation:The Automation of Cancer Cytology and Cell Image Analysis (Editors, Norman J. Pressman and George L. Wied), 13-18, Tutorials of Cytology Chicago, Illinois, 1979.
 
5) M. Stoehr., et al:Dual Laser Flow Analysis and Sorting of Cells Includingthe Uterine Cerix:The Automation of Cancer Cytology and Cell Image Analysis(Editors, Norman J. Pressman and George L. Wied) ;75-80, Tutorials of Cytology Chicago, Illinois, 1979.
 
6) R. H. Jensen., et al:Multiparameter Flow Cytometry Applied Toward Diagnosis of Cervical Squamous cell Carcinoma:The Automation of Canaer Cytology and Cell Image Analysis (Editors, Norman J. Pressman and George L. Wied) ;95-102, Tutorials of Cytology Chicago, Illinois, 1979.
 
P.652 掲載の参考文献
1) Mullaney, P. F. et al:The Small Angle Light Scattering of Biological Cells. Biophysical Jounal 10:764, 1970.
 
2) Salzman, G. C., et al:Cell Classification by Laser Light Scattering:Identification and Separation of unstained Leukocytes. Acta Cytologica 19(4) :374, 1975.
 
3) Van den Engh, G. J.:Concentration of Haemopoietic Cells using a Light Activated Cell Sorter. Blood Cells 6(4) :609, 1980.
 
4) 福井谷祐一・他:フローサイトメトリーの癌臨床への応用. 癌と化学療法 9(7) :1204, 1982.
 
5) Meyer, R. A., et al:Light Scattering from nucleated biological cell. Biophys. J. 15:191, 1975,
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6) Otten, G. R.:Two Color Light Scattering Identifis physical Differences between Lymphocyts Subpopulations. Cytometry 3(3) :182, 1982,
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7) Watt S. M., et al:Isolation of Mouse Bone Marrow Neutrophils by Light Scatter and Autofluorescence. J. Histochem. Cytochem. 28(9) :934, 1980.
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8) Grogan, W. M., et al :Application of Light Scatter to Separation of Stem Cells. Blood 6:625, 1980.
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9) 福井谷祐一・他:Light Scatteringの造血器悪性腫瘍診断への応用. 最新医学 40(1):92, 1985.
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10) Martin, A., et al.:Charactarization and Sorting of Mouse Cytotoxic Macrophages by Their Light Scattering properties. Cytometry 4:250, 1983.
 
11) Porath-Furedi A., :The Mutual Effect of Hydrogen Ion Concentration and Osmotic Pressure on the Shape of Human Erythrocyte as Determined by Light Scattering and by Electronic Cell Volume Measurment. Cytometry 4:263, 1983.
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12) Benson, M. C., :The Application of Perpendicular and Forward Light Scatter to Assess Nuclear and Cellular Morphology. Cytometry 5:515, 1984.
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13) Rigler, R., et al.:Rotation and Translational Swimming of Human Spermatozoa. A Dynamic Laser Light Scattering Study. Cytometry 5:327, 1984.
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14) Paul, L. McNeil., et al.:Light-Scattering changes During Chemotactic Stimulation of Human Neutrophils:Kinetics Followed by Flow Cytometry. Cytometry 6:7, 1985.
 
15) Terestappen, L. W. M. M., et al:Physical Discrimination Between Human T-Lymphocyt Subpopulations by Means of Light Scattering, Revealing two populations of T8-positive Cells. Cytometry 7(2) :178, 1986.
 
16) Van Bockstaele, et al:Flow Cytometric Analysis of Hairly Cell Leukemia Using Right-Angle Light Scatter. Cytometry 7(2) :217, 1986.
 
17) Grooth, B. G. de. et al:White Blood Cell Differentiation Using Depolarized Orthogonal Light Scattering. Cpttometry(Supple) 35:1987.
 
18) MacDonald, H. R., et al:Light Scatter Analysis and Sorting of cells Activatedin Mixed Leukocyte Culture. Cytometry 3:55, 1982.
 

VIII. データ解析法

P.666 掲載の参考文献
1) Gray, J. W, Dean, P. N. and Mendelsohn, M. I., :Quantitative cell-cycle analysis, in Flow Cytometry and Cell Sorting(eds. Melamed. M. R., Mullaney, P. F. and Mendelsohn, M. I.) John Wiley and Sons. pp.383, 1979.
 
2) Barlogie, B. Drewinko, D. A., et al:Pulse cytophotometric analysis of synchronized cells in vitro. Cancer Res. 36:1176, 1976.
 
3) Takahashi, M.:Amultidhannel method for the analysis of DNA contentdistribution using flow cytometric data. Comput. Biomed. Res 14:506, 1981.
 
4) Watson, J. W.:The application of age distribution theory in the analysis of cytofluorimetric DNA histogram data, Cell Tssue Kinet. 10:157, 1977.
 
5) Kim, M. and Perry, S.:Mathematical model for determining cell DNA synthesis rate and age distribution utilizing flow microfluorometry. J. Theoret. Biol. 68:27, 1977.
 
6) Woo, K. B.:The discrete-time kinetic model analysis of DNA distributions inexperimental tumor cells. Cell Tissue Kinet. 12:111, 1979.
 
7) Kraemer, P. M., Petersen, D. F. and Van Dilla, M. A.:DNA constancy inheteroploidy and the stem line theory of tumors, Science 174:714, 1971.
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8) Kraemer, P. M., Deaven, L. L, Crissman, H. A. and Van Dilla, M. A.:DNAconstancy despite variability in chromosome number. Adv. Cell Molec. Biol. 2:47, 1972.
 
9) Fried, J.:Method for the quantitative evaluation of data from flow micro-Huorometry. Comput. Biomed. Res. 9:263, 1976.
 
10) Dean, P. N. and Jett, J. H.:Mathematical analysis of DNA distributionsderived from flow microfluorometry. J. Cell Biol. 60:523, 1974.
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11) Van der Linden, P. M.:An iterative method of analysis for DNA histograms. in Flow Cytometry IV, (eds. Laerum, O. D., Lindmo, T. and Thorud. E.) Universitetforlaget, pp.133, 1980.
 
12) Takahashi, M.:DNA histogram analysis of exponentially growing and perturbed cell populations. in Biomathematics and Cell Kinetics(ed. Rotenberg, M.) Elsevier/North-Holland, pp.211, 1981.
 
13) Dean. P. N., Gray, J. W. and Dolbeare, F. A.:The analysis and interpretationof DNA distributions measured by flow cytometry. Cptometry 3:188, 1982.
 
P.675 掲載の参考文献
1) 高瀬浩造:Flow cytometryを用いた蛍光標識モノクローナル抗体染色陽性細胞率の算定方法. 最新医学 40:45, 1985.
 
2) Takase, K., et al:Quality control approach to the lymphocyte immunophentoyping. Proceedings of the 6th International Symposium on Quality Control-Osaka. Excerpta Medica, Tokyo. (in press)
 
3) 高瀬浩造・他:フローサイトメトリーによる表面形質分析における陽性率算出法についての検討 -とくにDEST 3のアルゴリズムについて-. 臨床免疫 17:408, 1985.
 
4) 高瀬浩造・他:モノクローナル抗体による細胞表面抗原検出における非特異反応の成因とその除去に関する研究. 日本臨床免疫学会会誌 8:184, 1985.
 
5) Nelder, J. A., et al:Asimplex method for function minimization. Computer J. 7:30 8, 1965.
 
6) Takase, K., et al:Cytoplasmic CD3 antigen and T cell receptor gene rearrangement in surface CD3 negative T cell malignancy. Jpn. J. Clin. Oncol. 17:237, 1987.
 
7) 野々山恵章:細胞質内μ鎖の検出法. 臨床免疫 19 〔Suppl.12〕:44, 1987.
 
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2) Oi, V. T, Glazzer, A. N., et al.:Fluorescent Phycobiliprotein Conjugates for analyses of cells and molecules. J. Cell Biol. 93:981-986, 1982.
 
3) Loken, M. R. et al.:Three-Color Immunofluorescence Analysis of Leu-Antigens on Human Peripheral Blood Using Two Lasers on a Fluorescence-Actirated Cell Sorter. Cytometry 5(2) :151-158, 1984.
 
4) Parks, D. R. Hardy, R. R. Herzenberg, L. A.:Three-Color Immunofluorescence Analysis of Mouse B-Lymphocyte Subpopulations. Cytometry 5(2) :159-168, 1984.
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5) Steinkamp, J. A. et al:A Modular Detector for Flow Cytometric Multicolor Fluorescence Measurements. Cpttometry 8(4) :353-365, 1987.
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IX. その他

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2) 酒井 寛・他:Flow cytometryによる好中球貧食能試験の測定条件について. 衛生検査 35(10):1421-1424, 1986.
 
3) 合地研吾・他:臨床血液. 抄録:1985.
 
4) 多賀千之・他:フローサイトメトリーを用いた微量全血法による好中球機能検査. 臨床免疫 17(5):490-485, 1985.
 
5) 岩瀬正泰:血漿ファイブロネクチンの好中球機能への影響. 炎症7(1):73-77, 1987.
 
6) 杉之下俊彦:単球貧食能測定法-フローサイトメトリー手技と実際- (太田和雄他編). 蟹書房 pp.498-505, 1984.
 
7) 岩崎秀生・他:蛍光ビーズを用いた末梢血Leu-M3陽性細胞の貧食能の測定. FCM-cell Biology研究会:1987.
 
8) 山田充宏・他:フローサイトメトリを用いた肺胞マクロファージ貧食能測定法の特長と問題点. 日本臨床免疫学会抄録 p.336. 1987.
 
9) 鈴木是光・他:FCMによる白血球機能検査-貧食能検査を中心として-. 臨床病理 33(12):1338-1347, 1985.
 
10) Owen, C. Blair., et al:Differentiation of HL-60 Promyelocytic Leukemia Cells:Simultaneous Determination of Phagocytic Activity and Cell Cycle Distribution by Flow Cytometry. Cytometry 7:171-177, 1986.
 
11) Bassoe, C. F., et al:Simultaneous Measurment of Phagocytosis and Phagosomal pH by Flow Cytometry:Role of Polymorphonuclear Neutrophilic Leucocyte Granules in Phagosome Acidification. Cytometry 4:254-262, 1983.
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12) John, A. Steinkanp., et al:Phagocytosis:Flow Cytometry Quantitation. with Fluoresent Microspheres. Science 215(1) :64-66, 1982.
 
13) 渡部一郎・他:Flow cytometryを用いた全血法による貧食能の検討. 日本臨床免疫学会抄録 p.282:1986.
 
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1) Krishan, A., et al:Effects of adriamycin and analogs on the nuclear fluorescence of propidium iodide-stained cells. Cancer Res. 38:3656-3662, 1978.
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2) Krishan, A. and Ganapathi, R.:Laser flow cytometry and cancer chemotherapy:detection of intracellular anthracyline by flow cytometry. J. Histochem Cpttochem. 27:1655-1656, 1979.
 
3) Krishan, A. and Ganapathi, R.:Laser flow cytometric studies on the intracellular fluorescence of anthracyclines. Cancer Res. 40:3885-3900, 1980.
 
4) Nooter, K., et al:Quantitative flow cytometric determination of anthracycline content of rat bone marrow cells. Cancer Res. 43:5126-5130, 1983.
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5) Krishan, A., et al:Flow cytometric studies on modulation of cellular adriamycin retention by phenothiazines. Cancer Res. 45:1046-1051, 1985.
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6) Skovsgaard, T.:Transport and binding of daunorubicin, adriamycin, and rubidazone in Ehrlich ascites tumor cells. Biochm Pharmacol. 26:215-222, 1977.
 
7) 佐々木功典・他:Flow cytometryによるadriamycin取り込み排出の解析. 日癌治誌 19:1028-1031, 1984.
 
8) Tapiero, H, et. al:Comparative uptake of adriamycin and daunomycin in sensitive and resistant friend leukemia cells measured by flow cytometry. Cytometry 2:298-302, 1982.
 
9) 長岡 栄・他:各種細胞におけるadriamycinの取り込み, 排泄及び感受性の解析. 日癌治誌 21:991-997, 1986.
 
10) Tokita, N., et al:Cell cycle-dependent adriamycin uptake in chinese hamster cells. Eur. J. Clin. Oncol. 21:243-247, 1985.
 
11) 佐々木功典・他:Flow cytometryによる3T3細胞内アドリアマイシンの測定. 日癌治誌 20:66-70, 1985.
 
12) Tsuruo, T., et al:Circumvention of VCR and ADR resistance in vitro and in vivo by calcium influx blockers. Cancer Res. 43:2905-2910, 1983.
 
13) 川崎 祥二・他:Adriamycinの細胞内取り込みへのhyperthermiaの影響. 日医放射線会誌 44:727-731, 1984.
 
14) 長岡 栄・他:アルカロイド(セファランチン)によるアドリアマイシンの細胞内取り込みおよび排泄の修飾. 医学のあゆみ 133:260-261, 1985.
 
15) Nagaoka, S., et al:Intracellular uptake, retention and cytotoxic effect of adriamycin combined with hyperthermia in vitro. Gann 77:205-211, 1986.
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16) Nagaoka, S., et al:Modification of cellular efflux and cytotoxicity of adriamycin by biscoclaulin alkaloid in vitro. Eur. J. Clin Oncol. 23:1297-1302, 1987.
 
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18) Krishan, A., et al:Flow cytometric monitoring of cellular anthracyclineaccumulation in murine leukemic cells. Cancer Res. 46:1768-1773, 1986.
 
19) Willingham, M. C., et al:Single cell analysis of daunomycin uptake and efflux in multidrug-resistant and-sensitive KB cells:effects of verapamil and otherdrugs. Cancer Res. 46:5941-5946, 1986.
 
P.724 掲載の参考文献
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X. 新しいFCMの装置

P.755 掲載の参考文献
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XI. 各種機器

P.775 掲載の参考文献
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6) Gohde, W., Schumann, J., Zante, J.:The useof DAPI in pulse cytophotometry. Pulse Cytophotometry 1978, pp.229-232.
 
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