Cyto-protection ＆ biology Vol.16 1998年 第16回 サイトプロテクション研究会

出版社： 癌と化学療法社
著者：
発行日： 1998-12-14
分野： 臨床医学：基礎  >  臨床細胞学
ISSN： 0289-368
電子書籍版： 1998-12-14
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1998年　第16回　サイトプロテクション研究会。今回の研究会は、26題の一般講演に加え、「NO代謝病態と生物の生存戦略」と題するシンポジウム講演が6演題、および「動物の時間」と題する特別講演より構成することができた。

目次

  • 表紙
  • 序文
  • 目次
  • 特別寄稿
  • グルタチオン研究の新たな展開
  • Session 胃1
  • 座長
  • 胃および十二指腸アルカリ分泌におけるEP受容体サブタイプの検討
  • 急性ストレス負荷時の胃粘膜におけるストレス蛋自質の誘導のメカニズムとその生理作用について
  • Session 胃2
  • 座長
  • 胃・十二指腸粘膜の適応性反応とシクロオキシゲナーゼ (COX) アイソザイム
  • ラット塩酸潰瘍治癒過程におけるcyclooxygenasesの発現とその役割
  • 胃炎から発癌への過程におけるコネキシン32の発現の動態
  • Session 消化器
  • 座長
  • イレウスにおけるサイトカイン測定の意義
  • TNB惹起性大腸炎におけるP-selectinの関与
  • Session 肝
  • 座長
  • 肝ミトコンドリア遺伝子の転写と複製に及ぼす慢性肝炎と肝硬変の影響
  • 肝細胞におけるウルソデオキシコール酸のステロイド作用増強効果について
  • Session 肝とフリーラジカル
  • 座長
  • エンドトキシン誘発肝障害における活性酸素の類洞内皮細胞傷害機序について
  • 敗血症病態におけるNO代謝と肝チトクロームP450代謝制御
  • Session 活性酸素・NO
  • 座長
  • 脳浮腫に対する一重項酸素消去剤の抗脳浮腫効果
  • 島状皮弁の虚血再灌流傷害におけるNOおよび活性酸素の関与
  • Session 血液・血管
  • 座長
  • 血小板凝集活性化に及ぼす血小板モノアミンオキシダーゼの役割
  • アデノウイルスベクターを用いた血管平滑筋細胞へのIL-1Ra遺伝子導入に関する実験的検討
  • シンポジウム「NO代謝病態と生物の生存戦略」
  • 両生類メタモルフォーシスと活性酸素代謝―水棲生物から陸棲動物への変身―
  • 心筋細胞の内因性NO産生と酸化的ストレス障害
  • Helicobacter pyloriの呼吸系に対するNOの阻害作用
  • 研究会会則
  • 役員リスト
  • 会告
  • 奥付

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本参考文献は電子書籍掲載内容を元にしております。

P.7 掲載の参考文献
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Session 胃1

P.12 掲載の参考文献
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2) Robert A, Nezamis JE and Philips JP: Inhibinon of gastric secretion by prostaglandins. Am. J. Digest Dis. 12: 1073-1075, 1967.
 
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5) Takeuchi K, Magee D, Critchlow J. et al: Study of the pH gradient and thickness of frog gastric mucus gel Gastroenterology 84: 331-340, 1983.
 
6) Namba T, Sugimoto Y, Negishi M, et al: Alternative splicing of C-terminal tail of prostaglandin E receptor subtype EP3 determines G-protein specificity. Nature 365: 166-170, 1993.
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P.16 掲載の参考文献
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3) Hirakawa T, Rokutan K, Kishi K. et al: Geranylgeranylacetone induces heat shock protci ll s, in cultured guinea pig gastric mucosal cells and rat gastric mucosa. Gastroenterology 111: 345-357, 1996,
 
4) Minowada G and Welch WJ: Clinical implications of stress response. J. Clin. Invest. 95: 3-12, 1995.
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5) Hendric JP and Hartl FU: Molccular chaperon functions of the heat shock proteins. Annu. Rev. Biochem. 62: 349-384, 1993.
 
6) Suzuki K, Sawa Y, Matsuda H. et al: In vivo gene transfection with heat shock protein 70 enhances myocardial tolerance to Ischemia-reperfusion injury in rat. J. Clin. Invest. 99: 1645-1650,1997.
 
7) Morimoto RI, Sarge KD, Abravaya K. et al: Transcriptional regulation of heat syock genes. J. Biol. Chem. 267: 21987-21990, 1992.
 
P.21 掲載の参考文献
1) Vane JR, Mitchell JA, Appleton L et al: Inducible isoforms of cyclooxygenase and nitric-oxide synthase in inflammation.Proc. Natl Acad. Sci. USA 91: 2046-2050, 1994.
 
2) Takeuchi K, Ueshima K, Ohuchi T, et al: Role of capsaicin-sensitive sensory neurons in healing of HCI-induced gastric mucosal lesions in rats. Gastroenterology 106: 1524-1532, 1994.
 
3) Futaki N, Takahashi S, Yokoyama M, et al: NS-398. a new anti-inflammatory agent, selectively inhibits prostaglandin G /H synthase/ cyclooxygenase (COX-2) activity in vitro itro. Prostaglandins 47: 55-59, 1994.
 
4) Nakatsugi S, Terada N, Yoshimura T, et al: Effects of nimesulide, a preferential cyclooxygenase-2 inhibitor, on carrageenan-induced pleurisy and stress-induced gastric lesions in rats.Prostaglandins Leuko. Essent. Fatty Acids 55: 395-402, 1996.
 
5) Takeuchi K. Furukawa O, Tanaka H. et al: A new model of duodenal ulcers induced in rats by indomethacinplus histamine. Gastroenterology 90: 636-645, 1986.
 
6) Whinle BJR: The potentiation of taurocholate-induced rat gastric erosions following parenteral administration of cyclooxygenase inhibitors. Br.J. Pharmacol. 80: 545-551, 1983.
 
7) Silen W: Gastric mucosal defense and repair. In Physiology of the gastrointestinal tract (edited by Johnson LR. Christensen J. Grossman MI, et al), Raven Press, New York,1987, pp.1055-1069.
 
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9) Ahlquist D, Dozois PR, Zinzmeister AR, et al: Duodenal prostaglandin systhesis after acid load in heahh and in duodenal ulcer diseases. Gastroenterology 85: 522-528, 1983.
 
P.25 掲載の参考文献
1) Ito T, Hayashi N, Sasaki Y, et al: Sequential protooncogene expression during regeneration in ratstoniach. Gastroenterology 98:1 1525-1531, 1990.
 
2) Sawaoka H, Tsuji S, Kawano S. et al: Expresslon of cyclooxygenase-2 and other immediate early genesin rat gastric mucosa in ulcer healing. Gastroenterology 108 (Suppl. 4) : A211, 1995.
 
3) Whittle BJR, Lopez-Belmonte J and Moncada S: Regulation of gastric mucosal integrity by endogenous nitric oxide: interactions with prostanoids and scnsory neuropeptide: in the rat. Br. J. Pharmacol. 99: 607-611, 1990.
 
4) Tsuji S, Kawano S, Sasayama Y, et al: Gastric mucosal cell proliferation and TGF αi n the healing of peptic ulcers in human subjects. J. Clin. Gastroenterol. 21 (Suppl. 1) : S30-S35, 1995.
 
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P.29 掲載の参考文献
1) Kanno Y and Matui Y: Cellular uncoupling in cancerous stomach epithelium. Nature 218: 775-776, 1968.
 
2) Kyoi T, Ueda F, Kimura K. et al: Development of gap junctions between gastric surface mucosa cells during cell maturation in rats. Gastroenterolog 102: 1930-1935, 1992.
 
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4) Mine T, Kushima R and Fujita T: Relationship between healing of acetic acid-induced chronic gastric ulcer and connexin. J. Clin. Gastroenterol. 25: S111-S115, 1997.
 
5) Correa P, Haenszel W, Cuello C, et al: Gastric pre-cancerous process in a high risk population: cross sectional studies. Cancer Res.50: 4731-4736, 1990.
 

Session 消化器

P.33 掲載の参考文献
1) 和田哲成, 長畑洋司, 安積靖友・他: 複雑性イレウスにおける血管凝固因子の検討.神戸大医紀 57: 1-9, 1996.
 
2) 和田哲成, 長畑洋司, 安積靖友・他: ラットにおける新しいイレウスモデルの作成.日消外会誌 27: 1870, 1994.
 
3) Neilly PJD, Gardiner KR, Kirk SJ, et al: Endotoxaemia and cytokine production in experimental colitis. Br. J. Surg.82 : 1479-1482 ,1995.
 
4) 平田公一: エンドトキシン血症,DICとSIRS. 消化器外科 18: 193-199, 1995.
 
P.36 掲載の参考文献
1) 吉田憲正, 山口泰司, 杉本尚仁・他: TNB惹起性大腸炎における接着分子ICAM-1の役割. Prog. Med.17: 1959-1961, 1997.
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5) Yoshida N, Granger DN, Evans DJ, et al: Mechanisms involved in Helicobacter pylori-induced inflammation, Gastroenterology 105: 1431-1440, 1993.
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6) Yoshida N, Yoshikawa T, Nakamura Y, et al: Role of neutrophil-mediated inflammation in aspirin-induced gastric mucosal injury. Dig. Dis. Sci. 40: 2300-2304, 1995.
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7) Schurmann GM, Bishop AE. Facer P, et al: Increased expression of cell adhesion molecule P-selectin in active inflammatory bowel disease. Gut 36: 411-418, 1995.
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8) Tojo SJ, Yokota S, Koike H, et al: Reduction of rat myocardial ischemia and reperfusion injury by sialyl Lewis x oligosaccharide and anti-rat P-setectin antibodies. Glycobiology 6: 463-469, 1996.
 
9) Ohnishi M, Koike H. Kawamura N, et al: Role of P-selectin in the early stage of the Arthus reaction. Immunopharmacology 34: 161-170, 1996.
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10) 吉田憲正, 吉川敏一, 山口泰司・他:ラットTNB惹起性大腸炎における活性酸素の関与. Prog. Med. 16: 2479-2482, 1996
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P.38 掲載の参考文献
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6) Murakami T, Shimomura Y, YoshimLira A. et al: Induction of nuclear respiratory factor-1 expression by an acute bout of exercise in rat muscle. Biochim. Biophys. Acta 1381: 113-122, 1998.
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P.41 掲載の参考文献
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2) 美馬聡昭, 関谷千尋, 金川博史・他: 自己免疫 性肝炎におけるウルソデオキシコール酸の効果. 肝臓 34: 849-850,1993.
 
3) Takano S, Ito Y, Yokosuka O, et al: A multicenter rando)mized controlled dose study of ursodeoxy-cholic acid for chronic hepatitis C. Hepatology 20: 558-564, 1994.
 
4) Mitsuyoshi H, Nakashima T, Inaba K, et al: Ursodeoxycholic acid decreases the serum transaminase levels of chronic liver disease patients treated with glycyrrhizin. Int. Hepatol Commun. 6: 85-91, 1996.
 
5) 中嶋俊彰, 光吉博則, 稲葉弘二・他: 慢性肝疾患におけるUDCAとグリチルリチン製剤の併用効果について.Cyto-protection & biology 14: 51-53, 1996.
 
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7) Bouscarel B, Fromm H and Nussbaum R: Ursodeoxycholate mobilizes intracellular Ca2+ and activates phosphorylase a in isolated hepatocytes. Am. J. Physiol. 264: G243-G251, 1993.
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8) Bouscarel B, Gettys TW, Fromm H, et al: Ursodeoxycholic acid inhibits glucagon-induced cAMP formation in hamster hepatocytes: a role for PKC. Am. J. Physiol.268: G300-G310, 1995.
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Session 肝とフリーラジカル

P.46 掲載の参考文献
1) 長谷川忠,中野 稔,桜井敏雄・他: O2産生能からみた敗血症肝障害における脾臓の役割. Cyto-protection & biolog 14: 91-94,1996.
 
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3) Uehara K, Maruyama N, Nakano M, et al: The first application of chemiluminescence probe. 2-methyl-6-[p-methoxyphenyl]-3, 7-dihydroimidazo [1,2-a] pyrazin-3-one (MCLA), for detecting O2 production, in vitro, from Kupffer cells stimulated by phorbol myristate acetate. FEBS Lett.335: 167-170, 1993.
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4) Nakano M, Kikuyama M, Hasegawa T. et al: The first observation of O2 generation at real time in vivo from non-Kupffer sinusoidal cells in perfused rat liver during acute ethanol intoxication. FEBS Lett. 372: 140-143, 1995.
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5) Koga S and Nakano M: A high involvement of O2 possibly generated in inner membranes for iron-induced microsomal lipid peroxidation. Biochem. Biopyhs. Res. Commun. 186: 1087-1093, 1992.
 
P.50 掲載の参考文献
1) Palmer RMJ, Ferrige AG and Moncada S: Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor. Nature 327: 524-526, 1987.
 
2) Inoue M. Minamiyama Y and Takemura S: Dynamic Aspectg. of Nitric Oxide Metabolism in The Circulation and Tissues.Methods Enzymol. 269: 474-479, 1996.
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4) Minamiyama Y, Takemura S, lmaoka S, et al: Irreversible inhibition of cytochrome P450 by nitric oxide.J. Pharmacol. Exp). Ther.283: 1479-1485, 1997.
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P.53 掲載の参考文献
1) Ikeda Y alld Long DM: The niolecular basis of brain imjury and brain edema: The role or oxygen free radicals. Neurosurgey 27: 1-11, 1990.
 
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3) Mizukawa H and Okabe E: Inhibition by singlet molecular oxygen of the vascular reactivity in rabbit mesenteric artery. Br. J. Pharmacol. 121 : 63-70, 1997.
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4) 竹内 功, 高島一敏, 川合明彦・他: Histidineの細胞緩衝作用を利用した心保存液による犬心の長時間保存.日胸外会誌 43 :1895-1901, 1995.
 
5) 川本俊樹, 池田幸穂, 寺本 明: ラット一過性前脳虚血時におけるL-histidine (singlet oxygen scavenger)の脳保護効果.脳と神経 49:612-618, 1997.
 
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P.57 掲載の参考文献
1) 厳 淳讃, 鈴木茂彦, 西村義彦: 皮弁生着メカニズムにおけるNOの関与. Cyto-protection & biology 14: 87-90, 1996.
 
2) Beckman JS. Beckman TW, Chen J, et al: Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide.Proc. Natl Acad. Sci. USA 87: 1620-1624, 1990.
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3) Uchida K, Szweda LI, Chae HZ, et al: Immuno-chemical detection of 4-hydroxy-nonenal protein adducts in oxidized hepatocytes. Proc. Natl Acad. Sci. USA 90: 8742-8746, 1993.
 
4) Kaur H and Halliwell B: Evidence for nitric oxide-mediated oxidative damage in chronic inflmation, Nitrotyrosine in serum and synovial fluid from rheumatoid patients. FEBS Lett.350 : 9-12,1 994.
 
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6) Wang P and Jweier JL : Measurement of nitric oxide and peroxynitrite generation in the postischemic heart.. J. Biol Che 1. 271: 29223-29230, 1996.
 
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Session 血液・血管

P.62 掲載の参考文献
1) 諸岡 弘: 脳梗塞再発予防に対する最適抗血小板薬の検討. Cyto-ptotection & biology 14: 67-70, 1996.
 
2) 諸岡 弘: 脳梗塞時の血小板凝集活性化に及ぼす交感神経の役割. Cyto-ptotection & biology 15: 71-74, 1997.
 
3) Hecker G, Utz J, Kupferschmidt RJ, ct al: Low levels of hydrogen peroxide ellhance platelet aggregation by cyclooxygenase activation. Eicosanoids 4: 107-113, 1991.
 
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7) Iuliano L, Pratico D, Bonavita MS, et al: Involvement of phospholipase A2-dependent platelet activation. Platelets 2: 87-90, 1992.
 
8)Satrustegui J and Richter C: Thc role of hydroper-oxides as calcium release agents in rat brain mitochondria. Arch. Biochem. Biophys. 233: 736-740, 1984.
 
P.65 掲載の参考文献
1) Chervu A and Moore WS: An overview of intimal hyperplasia. Surg. Gynecol. Obstett. 171: 433, 1990.
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2) Libby P, Schwartz D, Brogi E, et al: A cascade model for restenosis: a special case of atherosclerotic progregesion. Circulation 86 (Suppl III) : 47-52, 1992.
 
3) Libby P, Marin ML Lyon RT. et al: Immunolocalization and temporal distribution of cytokine expression during the development of vein graft intimal hyperplasia in an experimental model. J. Vasc. Surg 24: 463-471,1996.
 
4) Kancgae Y, Makimura M and Saito l: A simple and efficicnt mcthod for purification of infectious recom binant adenovirus. Jpn. J. Med. Sci. Biol. 47: 157-166, 1994.
 
5) Zwolac RM, Adams MC and Clowes AW: Kinetics of vein graft hyperplasia: association with tangential stress. J. Vasc. Surg. 5 : 126-136, 1987.
 
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