ファーマナビゲータ DIC編 改訂版

出版社: メディカルレビュー社
著者:
発行日: 2019-09-10
分野: 臨床医学:一般  >  薬物療法
ISBN: 9784779222337
電子書籍版: 2019-09-10 (初版第1刷)
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播種性血管内凝固(DIC)の薬理作用をはじめ、分類、病態と治療、処方の実際を解説。トピックス、Q&Aも掲載する。略語一覧、和文・欧文索引付き。メモ欄あり。

目次

  • Chapter 1 薬理作用
     1 概念と最近の進展:DICとは(DICのメカニズム)
     2 オンディマンド型反応系
     
    Chapter 2 DICの分類
     1 時間経過に基づいた分類
     2 凝固と線溶のダイナミズムからみた分類

    Chapter 3 病態と治療
     1 病態基盤と病型 
     2 診断基準 
     3 治療総論(従来の治療と最新の治療)
     4 DICと鑑別が必要な疾患 血栓性微小血管症(TMA) 
     5 DICと鑑別が必要な疾患 溶血性尿毒症症候群(HUS)
     
    Chapter 4 処方の実際
     1 造血器悪性腫瘍とDIC 
     2 固形癌とDIC 
     3 外科のDIC(リスクの高い手術) 
     4 救急領域のDIC 
     5 新生児領域のDIC 
     6 産科・婦人科領域のDIC 
     7 DIC治療のEBM 

    Chapter 5 トピックス
     1 PAMPs/DAMPs
     2 類洞閉塞症候群(SOS 
     3 ヘパリン起因性血小板減少症(HIT) 
     4 プロカルシトニン・プレセプシン
     5 ADAMTS 13と血栓性血小板減少性紫斑病(TTP) 
     6 特発性肺線維症(IPF) 
     7 妊娠高血圧症候群
     8 抗リン脂質抗体症候群(APS)
     9 後天性フォンウィルブランド症候群(AVWS)
     10 細胞外DNAと対外循環回路閉鎖
     11 敗血症に伴うDIC
     12 日本版敗血症診療ガイドライン
     13 メディカルスタッフのDIC診療―看護師の立場から
     14 メディカルスタッフのDIC診療―臨床検査技師の立場から
     15 メディカルスタッフのDIC診療―薬剤師の立場から

    Chapter 6 Question&Answer
     1 いわゆる「線溶抑制型」DICと「線溶亢進型」DICでは,
        DIC治療薬の使い分けが必要でしょうか 
     2 SIRSはDICを合併しやすいと聞きます。
        SIRSという疾患概念について教えてください 
     3 敗血症患者におけるDIC治療は,予後の改善をもたらしますか 
     4 造血幹細胞移植に伴う合併症に対して,
        抗凝固療法はどの程度期待できますか 
     5 DPCを念頭においた場合,DICの治療戦略はどうあるべきでしょうか 
     6 小児に対するDIC治療薬の選択とそのエビデンスを教えてください 
     7 DICによって腎機能が障害された場合のDIC治療について,
        どのような点に留意すればよいでしょうか 
     8 急性期侵襲病態ではミトコンドリアはどのような役割をしているのでしょうか
     9 アンチトロンビンと遺伝子組換え型トロンボモジュリンの使い分けに対する
        考え方について教えてください
     10 熱中症に伴うDICの治療について教えてください

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本参考文献は電子書籍掲載内容を元にしております。

Chapter 1 薬理作用

P.32 掲載の参考文献

Chapter 2 DICの分類

P.46 掲載の参考文献
3) 和田英夫 : 播種性血管内凝固症候群 (DIC). 三輪血液病学 (浅野茂隆, 池田康夫, 内山卓監修). 文光堂, 東京, 2005, p 1743-1752
4) 青木延雄, 長谷川淳 : DIC診断基準の『診断のための補助的検査成績, 所見』の項の改訂について. 厚生省特定疾患血液凝固異常症調査研究班平成4年度業績報告集. 1988, p 37-41
5) Taylor FB Jr, Toh CH, Hoots WK et al : Towards definition, clinical and laboratory criteria, and a scoring system for disseminated intravascular coagulation. Thromb Haemost 86 : 1327-1330, 2001
6) Gando S, Iba T, Eguchi Y et al : A multicenter, prospective validation of disseminated intra vascular coagulation diagnostic criteria for critically ill patients : comparing current criteria. Crit Care Med 34 : 625-631, 2006
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9) Wada H, Minamikawa K, Wakita Y et al : Hemostatic study before onset of disseminated intravascular coagulation. Am J Hematol 43 : 190-194, 1993
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Chapter 3 病態と治療

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Chapter 4 処方の実際

P.125 掲載の参考文献
1) Wada H, Wakita Y, Nakase T et al : Outcome of disseminated intravascular coagulation in relation to the score when treatment was begun. Mie DIC Study Group. Thromb Haemost 74 : 848-852, 1995
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Chapter 5 トピックス

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8) 厚生労働省 : 医療スタッフの協働・連携によるチーム医療の推進について. 厚生労働省医政局長通知 (医政発0430 第1号). 2010
9) 一般社団法人日本病院薬剤師会. プロトコールに基づく薬物治療管理 (PBPM) の円滑な進め方と具体的実践事例 (Ver.1.0). 2016. http://www.jshp.or.jp/cont/16/0331-1.pdf

Chapter 6 Question & Answer

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