ベーチェット病診療ガイドライン 2020

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ベーチェット病標準化医療のバイブルがついに完成!ベーチェット病は,全身に多様な症状が出現する難治性炎症性疾患で,特異的な検査所見がないために診断に苦慮することも少なくありません.本書では多臓器にわたる症状を横断的に理解できるよう,治療に限らず症状や所見に関するアルゴリズム・CQを豊富に収録し,ベーチェット病の多彩な症状・所見・治療すべてを網羅.ベーチェット病専門外の一般医にも使いやすい1冊です.

目次

  • 第1章 ガイドライン作成にあたって

    第2章 ベーチェット病の疾患概念,病因・病態
     [1]疾患概念
     [2]病因・病態

    第3章 ベーチェット病の臨床
     [1]症状,身体所見
     (1)主症状
      (a)口腔内アフタ性潰瘍
      (b)皮膚症状
      (c)眼症状
      (d)外陰部潰瘍
     (2)副症状
      (a)関節炎
      (b)精巣上体炎(副睾丸炎)
      (c)消化器病変(腸管型ベーチェット病)
      (d)血管病変(血管型ベーチェット病)
      (e)中枢神経病変(神経型ベーチェット病)
     [2]血液生化学検査所見
     [3]厚生労働省ベーチェット病診断基準(2016年小改訂)
     [4]ベーチェット病重症度分類(2016年小改訂)
     [5]疫学(症状,重症度の変遷)
     [6]ベーチェット病患者の妊娠について
     [7]小児ベーチェット病の特徴

    第4章 ベーチェット病の診療ガイドライン
     [1]診断・治療に関するアルゴリズム
     (1)皮膚粘膜病変治療アルゴリズム
     (2)眼病変治療アルゴリズム
     (3)関節病変治療アルゴリズム
     (4)精巣上体炎診断治療アルゴリズム
     (5)腸管型ベーチェット病診断治療アルゴリズム
     (6)血管型ベーチェット病診断治療アルゴリズム
     (7)神経型ベーチェット病診断治療アルゴリズム
     [2]診断・治療のクリニカルクエスチョン(CQ)と推奨文,推奨度,解説
     (1)皮膚粘膜病変CQ
      (a)口腔内アフタ性潰瘍
      (b)外陰部潰瘍
      (c)結節性紅斑
      (d)毛包炎様皮疹
      (e)血栓性静脈炎
     (2)眼病変CQ
      (a)眼発作時の治療
      (b)眼発作抑制の治療(TNF 阻害薬以外の治療)
      (c)TNF阻害薬
      (d)眼科手術
     (3)関節病変CQ
     (4)精巣上体炎CQ
     (5)腸管病変CQ
      (a)診 断
      (b)予 後
      (c)モニタリングと治療目標
      (d)治療(内科的治療)・総論
      (e)治療(内科的治療)・各論
      (f)治療(外科的治療)
      (g)その他(小児例,トリソミー8など)
     (6)血管病変CQ
     (7)神経病変CQ
      (a)神経型ベーチェット病の一般的事項
      (b)急性型神経型ベーチェット病について
      (c)慢性進行型神経型ベーチェット病について
     (8)小児ベーチェット病CQ
     (9)治療総論CQ
      (a)TNF阻害薬に関する注意点
      (b)妊娠・授乳中の薬物治療リスク

    第5章 参考資料・情報
     [1]ベーチェット病国際診断基準(ISG, ICBD, PEDBDなど)との比較
     [2]神経型ベーチェット病メタ解析
     [3]ベーチェット病臨床調査個人票(2016年改訂)
     [4]関連情報
     [5]ベーチェット病患者会情報
     [6]ベーチェット病に関する調査研究班のあゆみ

この書籍の参考文献

参考文献のリンクは、リンク先の都合等により正しく表示されない場合がありますので、あらかじめご了承下さい。

本参考文献は電子書籍掲載内容を元にしております。

第1章 ガイドライン作成にあたって

P.5 掲載の参考文献
1. 福井次矢, 他 (編) : Minds診療ガイドライン作成の手引き 2007. 医学書院, 2007.
2. 福井次矢, 他 (編) : Minds診療ガイドライン作成の手引き 2014. 医学書院, 2014.

第2章 ベーチェット病の疾患概念, 病因・病態

P.11 掲載の参考文献
1. Behcet H : Uber rezidivierende, aphthose, durch ein Virus verursachte Geschwure am Mund, am Auge und an den Genitalien. Dermatol Wochenschr 1937 ; 105 : 1152-1157.
2. 黒澤潤三 : 再発性蓄膿性虹彩毛様体炎ノ一例. 中央眼科医報 1923 ; 15 : 653-656.
3. 重田達夫 : 前房蓄膿ヲ伴フ再発性虹彩炎ニ就テ及ソノ病理解剖. 日眼会誌 1924 ; 28 : 516-528.
4. Adamantiades B : A case of relapsing iritis with hypopyon (in Greek). Archia Iatrikis Etairias (Proceedings of the Medical Society of Athens). 1930 : 586-593.
5. Adamantiades B : Sur un cas d'iritis a hypopion recidivant. Ann Ocul (Paris) 1931 ; 168 : 271-278.
6. Ohno S, et al. : HL-A5 and Behcet's disease. Lancet 1973 ; 2 : 1383-1384.
7. Ohno S, et al. : HLA-BW51 and Behcet's disease. JAMA 1978 ; 240 : 529.
8. Mizuki N, et al. : Genome-wide association studies identify IL23R-IL12RB2 and IL10 as Behcet's disease susceptibility loci. Nat Genet 2010 ; 42 : 703-706.
9. Kirino Y, et al. : Genome-wide association analysis identifies new susceptibility loci for Behcet's disease and epistasis between HLA-B*51 and ERAP1. Nat Genet 2013 ; 45 : 202-207.
10. 大野重昭 : 眼疾患発症の外因と内因. 日眼会誌 2005 ; 109 : 885-915.
11. Ohno S, et al. : Close Association of HLA-Bw51 with Behcet's disease. Arch Ophthalmol 1982 ; 100 : 1455-1458.
12. Verity DH, et al. : Behcet's disease, the Silk Road and HLA-B51 : historical and geographical perspectives. Tissue Antigens 1999 ; 54 : 213-220.
13. 大野重昭, 他 : ベーチェット病の診療の歴史・疫学・疾患概論. 飯塚文瑛, 他 (編) : 腸管ベーチェット病のすべてがわかる診療ハンドブック. 先端医学社, 2018 : 2-11.
P.17 掲載の参考文献
1. Mizuki N, et al. : Genome-wide association studies identify IL23R-IL12RB2 and IL10 as Behcet's disease susceptibility loci. Nat Genet 2010 ; 42 : 703-706.
2. Remmers EF, et al. : Genome-wide association study identifies variants in the MHC class I, IL10, and IL23R-IL12RB2 regions associated with Behcet's disease. Nat Genet 2010 ; 42 : 698-702.
3. Kirino Y, et al. : Genome-wide association analysis identifies new susceptibility loci for Behcet's disease and epistasis between HLA-B*51 and ERAP1. Nat Genet 2013 ; 45 : 202-207.
4. KirinoY, et al. : Targeted resequencing implicates the familial Mediterranean fever gene MEFV and the toll-like receptor 4 gene TLR4 in Behcet disease. Proc Natl Acad Sci USA 2013 ; 110 : 8134-8139.
5. Miossec P, et al. : Interleukin-17 and type 17 helper T cells. N Engl J Med 2009 ; 361 : 888-898.
6. Leng RX, et al. : The role of IL23/IL17 axis in the etiopathogenesis of Behcet's disease. Clin Rheumatol 2010 ; 29 : 1209.
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8. Lasiglie D, et al. : Role of IL-1 beta in the development of human T (H) 17 cells : lesson from NLPR3 mutated patients. PLoS One 2011 ; 6 : e20014.
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第3章 ベーチェット病の臨床

P.21 掲載の参考文献
1. 中村晃一郎, 他 : ベーチェット病の皮膚粘膜病変診療ガイドライン. 日皮会誌 2018 ; 128 : 2087-2101.
P.23 掲載の参考文献
1. 中村晃一郎, 他 : ベーチェット病の皮膚粘膜病変診療ガイドライン. 日皮会誌 2018 ; 128 : 2087-2101.
P.25 掲載の参考文献
1. ベーチェット病眼病変診療ガイドライン作成委員会 : Behcet病 (ベーチェット病) 眼病変診療ガイドライン. 日眼会誌 2012 ; 116 : 394-426.
P.26 掲載の参考文献
1. 中村晃一郎, 他 : ベーチェット病の皮膚粘膜病変診療ガイドライン. 日皮会誌 2018 ; 128 : 2087-2101.
P.29 掲載の参考文献
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8. Kirino T, et al. : Genome-wide association analysis identifies new susceptibility loci for Behcet's disease and epistasis between HLA-B*51 and ERAP1. Nat Genet 2013 ; 45 : 202-207.
9. Kirino T, et al. : Targeted resequencing implicates the familial Mediterranean fever gene MEFV and the toll-like receptor 4 gene TLR4 in Behcet disease. Proc Natl Acad Sci U S A 2013 ; 110 : 8134-8139.
P.46 掲載の参考文献
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10. 永井正規, 他 : 特定疾患治療研究医療受給者調査報告書 (1992年度分) その1 基本的集計. 厚生省特定疾患難病の疫学班調査研究班. 1995.
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3. 岳野光洋 : ベーチェット病と妊娠. リウマチ科 2014 ; 52 : 69-75.
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11. Gul U : Pregnancy and Behcet disease. Arch Dermatol 2000 ; 136 : 1063-1064.
12. Uzun S, et al. : The clinical course of Behcet's disease in pregnancy : a retrospective analysis and review of the literature. J Dermatol 2003 ; 30 : 499-502.
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1. Ozen S : Behcet Disease. In : Petty RE, et al. (eds) : Textbook of Pediatric Rheumatology, 7th ed, Saunders, Philadelphia, 2016 ; 526-532 : e2.
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5. Kone-Paut I, et al. : Consensus classification criteria for paediatric Behcet's disease from a prospective observational cohort : PEDBD. Ann Rheum Dis 2016 ; 75 : 958-964.

第4章 ベーチェット病の診療ガイドライン

P.62 掲載の参考文献
1. Taylor J, et al. : Interventions for the management of oral ulcers in Behcet's disease. Cochrane Database Syst Rev 2014 ; 25 : CD011018.
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P.63 掲載の参考文献
1. Taylor J, et al. : Interventions for the management of oral ulcers in Behcet's disease. Cochrane Database Syst Rev 2014 ; 25 : CD011018.
1. Davatchi F, et al. : Colchicine versus placebo in Behcet's disease : randomized, double-blind, controlled crossover trial. Mod Rheumatol 2009 ; 19 : 542-549.
2. Yurdakul S, et al. : A double-blind trial of colchicine in Behcet's syndrome. Arthritis Rheum 2001 ; 44 : 2686-2692.
2. Mat C, et al. : A double-blind trial of depot corticosteroids in Behcet's syndrome. Rheumatology (Oxford) 2006 ; 45 : 348-352.
3. Verma KK, et al. : Severe mucocutaneous Behcet's disease treated with dexamethasone pulse. J Assoc Physicians India2005 ; 53 : 998-999.
3. Miyachi Y, et al. : Colchicine in the treatment of the cutanesous manifestations of Behcet's disease. Br J Dermatol 1981 ; 104 : 67-69.
P.64 掲載の参考文献
1. Matsuda T, et al. : Efficacy of rebamipide as adjunctive therapy in the treatment of recurrent oral aphthous ulcers in patients with Behcet's disease : a randomised, double-blind, placebo-controlled study. Drugs R D 2003 ; 4 : 19-28.
1. Calguneri M, et al. : Effect of prophylactic benzathine penicillin on mucocutaneous symptoms of Behcet's disease. Dermatology 1996 ; 192 : 125-128.
2. Al-Waiz MM, et al. : Colchicine and benzathine penicillin in the treatment of Behcet disease : a case comparative study. Dermatol Online J 2005 ; 11 : 3.
2. Alpsoy E, et al. : The use of sucralfate suspension in the treatment of oral and genital ulceration of Behcet disease : a randomized, placebo-controlled, double-blind study. Arch Dermatol 1999 ; 135 : 529-532.
P.65 掲載の参考文献
1. Hatemi G, et al. : Apremilast for Behcet's Syndrome-A phase 2, placebo-controlled Study. N Eng J Med 2015 ; 372 : 1510-1518.
1. Melikoglu M, et al. : Short-term trial of etanercept in Behcet's disease : a double blind, placebo controlled study. J Rheumatol 2005 ; 32 : 98-105.
2. Hatemi G, et al. : Apremilast for Behcet's syndrome : Abstract from EULAR Annual European Congress of Rheumatology, 2018.
2. Almoznino G, et al. : Infliximab for the treatment of resistant oral ulcers in Behcet's disease : a case report and review of the literature. Clin Exp Rheumatol 2007 ; 25 (Suppl 45) : S99-S102.
P.66 掲載の参考文献
1. Hatemi G, et al. : EULAR recommendations for the management of Behcet disease. Ann Rheum Dis 2008 ; 67 : 1656-1662.
1. Hatemi G, et al. : EULAR recommendations for the management of Behcet disease. Ann Rheum Dis 2008 ; 67 : 1656-1662.
2. Alpsoy E : New Evidence-Based Treatment Approach in Behcet's Disease. Patholog Res Int 2012 ; 2012 : 871019.
2. Alpsoy E : New Evidence-Based Treatment Approach in Behcet's Disease. Patholog Res Int 2012 ; 2012 : 871019.
3. Mat C, et al. : A double-blind trial of depot corticosteroids in Behcet's syndrome. Rheumatology (Oxford) 2006 ; 45 : 348-352.
P.67 掲載の参考文献
1. Chan WP, et al. : Combination therapy with infliximab and methotrexate in recalcitrant mucocutaneous Behcet disease. Cutis 2012 ; 89 : 185-190.
1. Aktulga E, et al. : A double blind study of colchicine in Behcet's disease. Haematologica 1980 ; 65 : 399-402.
2. Yurdakul S, et al. : A double-blind trial of colchicine in Behcet's syndrome. Arthritis Rheum 2001 ; 44 : 2686-2692.
2. Kasugai C, et al. : Infliximab treatment of severe genital ulcers associated with Behcet disease. J Am Acad Dermatol 2010 ; 62 : 162-164.
3. Davatchi F, et al. : Colchicine versus placebo in Behcet's disease : randomized, double-blind, controlled crossover trial. Mod Rheumatol 2009 ; 19 : 542-549.
3. Connolly M, et al. : Infliximab treatment for severe orogenital ulceration in Behcet's disease. Br J Dermatol 2005 ; 153 ; 1073-1075.
4. Gulli S, et al. : Remission of Behcet's disease with anti-tumor necrosis factor monoclonal antibody therapy : a case report. BMC Musculoskelet Disord 2003 ; 4 : 19.
5. Olivieri I, et al. : Successful treatment of recalcitrant genital ulcers of Behcet's disease with adalimumab after failure of infliximab and etanercept. Clin Exp Rheumatol 2009 ; 27 (Suppl 53) : S112.
P.68 掲載の参考文献
1. Alpsoy E : New Evidence-Based Treatment Approach in Behcet's Disease. Patholog Res Int 2012 ; 2012 : 871019.
1. Takeuchi A, et al. : Efficacy of oxaprozin in the treatment of articular symptoms of Behcet's disease. Clin Rheumatol 1984 ; 3 : 397-399.
2. Simsek H, et al. : Treatment of Behcet disease with indomethacin. Int J Dermatol 1991 ; 30 : 54-57.
3. Davatchi F, et al. : How to deal with Behcet's disease in daily practice. Int J Rheum Dis 2010 ; 13 : 105-116.
P.69 掲載の参考文献
1. Kaneko F, et al. : Streptococcal infection in the pathogenesis of Behcet's disease and clinical effects of minocycline on the disease symptoms. Yonsei Med J 1997 ; 38 : 444-454.
1. Sharquie KE, et al. : Dapsone in Behcet's disease : a double-blind, placebo-controlled, cross-over study. J Dermatol 2002 ; 29 : 267-279.
P.70 掲載の参考文献
1. Yurdakul S, et al. : A double-blind trial of colchicine in Behcet's syndrome. Arthritis Rheum 2001 ; 44 : 2686-2692.
1. Mat C, et al. : A double-blind trial of depot corticosteroids in Behcet's syndrome. Rheumatology (Oxford) 2006 ; 45 : 348-352.
2. Davatchi F, et al. : Colchicine versus placebo in Behcet's disease : randomized, double-blind, controlled crossover trial. Mod Rheumatol 2009 ; 19 : 542-549.
3. Aktulga E, et al. : A double blind study of colchicine in Behcet's disease. Haematologica 1980 ; 65 : 399-402.
P.71 掲載の参考文献
1. Melikoglu M, et al. : Short-term trial of etanercept in Behcet's disease : a double blind, placebo controlled study. J Rheumatol 2005 ; 32 : 98-105.
1. Alpsoy E, et al. : A randomized, controlled and blinded study of papulopustular lesion in Turkish Behcet's patient. Int J Dermatol 1998 ; 37 : 839-843.
2. Estrach C, et al. : Behcet's syndrome : response to infliximab after failure of etanercept. Rheumatology (Oxford) 2002 ; 41 : 1213-1214.
3. Sfikakis PP, et al. : Anti-TNF therapy in the management of Behcet's disease-review and basis for recommendations. Rheumatology (Oxford) 2007 ; 46 : 736-741.
P.72 掲載の参考文献
1. Davatchi F, et al. : Colchicine versus placebo in Behcet's disease : randomized, double-blind controlled crossover trial. Mod Rheumatol 2009 ; 19 : 542-549.
1. Mumcu G, et al. : Effects of azithromycin on intracellular cytokine responses and mucocutaneous manifestations in Behcet's disease. Int J Dermatol 2013 ; 52 : 1561-1566.
1. Kawakami T, et al. : Antiphosphatidylserine-prothrombin complex antibodies in 3 patients with Behcet disease involving superficial vein thrombophlebitis. Arch Dermatol 2009 ; 145 : 171-175.
2. Kawakami T, et al. : Significance of two skin biopsy performances with consecutive deeper sections in the differential diagnosis between cutaneous polyarteritis nodosa and livedo vasculopathy. Acta Derm Venereol 2014 ; 94 : 84-85.
P.73 掲載の参考文献
1. Assaad-Khalil SH : Low-dose cyclosporin in Behcet's diseas : follow-up controlled study with emphasis on extraocular manifestations and neuro-Behcet's disease. In : O' Duffy JD, et al. (eds) : Behcets Disease : Basic and Clinical Aspects. Marcel Dekker, New York, 1991 ; 603-612.
2. Cantini F, et al. : Treatment of thrombophlebitis of Behcet's disease with low dose cyclosporin A. Clin Exp Rheumatol 1999 ; 17 : 391-392.
3. Wu X, et al. : Behcet's disease complicated with thrombosis : a report of 93 Chinese cases. Medicine (Baltimore) 2014 ; 93 : e263.
4. Vikas A, et al. : Behcet's disease with relapsing cutaneous polyarteritis-nodosa-like lesions, responsive to oral cyclosporine therapy. Dermatol Online J 2003 ; 9 : 9.
P.74 掲載の参考文献
1. Dogan SM, et al. : Right ventricular thrombus with Behcet's syndrome : successful treatment with warfarin and immunosuppressive agents. Tex Heart Inst J 2007 ; 34 : 360-362.
1. Davatchi F, et al. : Colchicine versus placebo in Behcet's disease : randomized, double-blind, controlled crossover trial. Mod Rheumatol 2009 ; 19 : 542-549.
2. Yurdakul S, et al. : A double-blind trial of colchicine in Behcet's syndrome. Arthritis Rheum 2001 ; 44 : 2686-2692.
2. 福本智恵, 他 : 下肢の血栓性静脈炎に対しワルファリンカルシウムが奏効したベーチェット病の1例. 皮膚臨床 1998 ; 40 : 2075-2078.
3. Kawakami T, et al. : Antiphosphatidylserine-prothrombin complex antibodies in 3 patients with Behcet disease involving superficial vein thrombophlebitis. Arch Dermatol 2009 ; 145 : 171-175.
3. Shah B, et al. : Effect of colchicine on platelet-platelet and platelet-leukocyte interactions : a pilot study in healthy subjects. Inflammation 2016 ; 39 : 182-189.
4. Ozen S, et al. : Behcet disease : treatment of vascular involvement in children. Eur J Pediatr 2010 ; 169 : 427-430.
P.75 掲載の参考文献
1. Evereklioglu C : Current concepts in the etiology and treatment of Behcet disease. Surv Ophthalmol 2005 ; 50 : 297-350.
1. Evereklioglu C : Ocular Behcet disease : current therapeutic approaches. Curr Opin Ophthalmol 2011 ; 22 : 508-516.
2. Evereklioglu C : Ocular Behcet disease : current therapeutic approaches. Curr Opin Ophthalmol 2011 ; 22 : 508-516.
2. Dunne JA,et al. : Double-blind clinical trial of topical steroids in anterior uveitis. Br J Ophthalmol 1979 ; 63 : 762-767.
P.76 掲載の参考文献
1. Ohno S, et al. : Behcet's disease. In : Zierhut M, et al. (eds) : Intraocular Inflammation. Springer-Verlag Berlin Heidelberg, Heidelberg, 2016 : 785-795.
P.77 掲載の参考文献
1. Evereklioglu C : Ocular Behcet disease : current therapeutic approaches. Curr Opin Ophthalmol 2011 ; 22 : 508-516.
1. Okada AA, et al. : Trans-Tenon's retrobulbar triamcinolone infusion for the treatment of uveitis. Br J Ophthalmol 2003 ; 87 : 968-971.
2. Sen HN, et al. : Periocular corticosteroid injections in uveitis : effects and complications. Ophthalmology 2014 ; 121 : 2275-2286.
3. Ohno S, et al. : Behcet's disease. In : Zierhut M, et al. (eds) : Intraocular Inflammation. Springer-Verlag Berlin Heidelberg, Heidelberg, 2016 ; 785-795.
4. Markomichelakis N, et al. : A single infliximab infusion vs corticosteroids for acute panuveitis attacks in Behcet's disease : a comparative 4-week study. Rheumatology (Oxford) 2011 ; 50 : 593-597.
P.78 掲載の参考文献
1. Evereklioglu C : Current concepts in the etiology and treatment of Behcet disease. Surv Ophthalmol 2005 ; 50 : 297-350.
1. Matsumura N, et al. : Leucocyte movement and colchicine treatment in Behcet's disease. Lancet 1975 ; 2 : 813.
2. 三村康男 : ベーチェット病の眼病変に対するコルヒチンの使用経験. 眼紀 1975 ; 26 : 902-908.
3. 松尾信彦, 他 : ベーチェット病のコルヒチン療法. 厚生省特定疾患ベーチェット病調査研究班 昭和51年度研究業績集 (班長 ; 清水保). 1977 : 147-151.
4. 水島裕, 他 : ベーチェット病のコルヒチン療法. リウマチ 1978 ; 18 : 112-115.
5. 熊代修 : 眼疾患に対するコルヒチン療法の研究. 眼紀 1984 ; 35 : 636-643.
6. 大野重昭, 他 : ベーチェット病眼病変診療ガイドライン. 日眼会誌 2012 ; 116 : 394-426.
7. Levy-Clarke G, et al. : Expert panel recommendations for the use of anti-tumor necrosis factor biologic agents in patients with ocular inflammatory disorders. Ophthalmology 2014 ; 121 : 785-796.
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2. 斎藤一宇, 他 : Behcet病のコルヒチン療法の検討. 眼科 1977 ; 19 : 115-120.
3. 松尾信彦, 他 : ベーチェット病のコルヒチン療法. 厚生省特定疾患ベーチェット病調査研究班 昭和51年度研究業績集 (班長 ; 清水保). 1977 : 147-151.
4. Sarica K, et al. : Urological evaluation of Behcet patients and the effect of colchicine on fertility. Eur Urol 1995 ; 27 : 39-42.
5. 柴田興一, 他 : サイクロスポリン使用中にミオパチーを呈したBehcet's病の一症例. 臨床神経学 1991 ; 31 : 847-852.
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1. Gotestam Skorpen C, et al. : The EULAR points to consider for use of antirheumatic drugs before pregnancy, and during pregnancy and lactation. Ann Rheum Dis 2016 ; 75 : 795-810.
1. Gotestam Skorpen C, et al. : The EULAR points to consider for use of antirheumatic drugs before pregnancy, and during pregnancy and lactation. Ann Rheum Dis 2016 ; 75 : 795-810.
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6. 齋藤滋, 他 : 全身性エリテマトーデス (SLE), 関節リウマチ (RA), 若年性特発性関節炎 (JIA) や炎症性腸疾患 (IBD) 罹患女性患者の妊娠, 出産を考えた治療指針. 厚生労働科学研究費補助金難治性疾患等政策研究事業 (難治性疾患政策研究事業) 「関節リウマチ (RA) や炎症性腸疾患 (IBD) 罹患女性患者の妊娠, 出産を考えた治療指針の作成」研究班 平成28年度~29年度総合研究報告書 (研究代表者 ; 齋藤滋). 2018 : 28-35.
7. 日本産科婦人科学会, 他 : 産婦人科診療ガイドライン-産科編 2017. http://www.jsog.or.jp/activity/pdf/gl_sanka_2017.pdf (アクセス日 : 2018年8月7日)
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P.166 掲載の参考文献
1. Julsgaard M, et al. : Concentrations of Adalimumab and Infliximab in Mothers and Newborns, and Effects on Infection. Gastroenterology 2016 ; 151 : 110-119.
1. Gotestam Skorpen C, et al. : The EULAR points to consider for use of antirheumatic drugs before pregnancy, and during pregnancy and lactation. Ann Rheum Dis 2016 ; 75 : 795-810.
2. 齋藤滋, 他 : 全身性エリテマトーデス (SLE), 関節リウマチ (RA), 若年性特発性関節炎 (JIA) や炎症性腸疾患 (IBD) 罹患女性患者の妊娠, 出産を考えた治療指針. 厚生労働科学研究費補助金難治性疾患等政策研究事業 (難治性疾患政策研究事業) 「関節リウマチ (RA) や炎症性腸疾患 (IBD) 罹患女性患者の妊娠, 出産を考えた治療指針の作成」研究班 平成28年度~29年度総合研究報告書 (研究代表者 ; 齋藤滋). 2018 : 39-42.
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3. Julsgaard M, et al. : Concentrations of Adalimumab and Infliximab in Mothers and Newborns, and Effects on Infection. Gastroenterology 2016 ; 151 : 110-119.
3. van der Woude CJ, et al. : The second European evidenced-based consensus on reproduction and pregnancy in inflammatory bowel disease. J Crohns Colitis 2015 ; 9 : 107-124.
4. 齋藤滋, 他 : 全身性エリテマトーデス (SLE), 関節リウマチ (RA), 若年性特発性関節炎 (JIA) や炎症性腸疾患 (IBD) 罹患女性患者の妊娠, 出産を考えた治療指針. 厚生労働科学研究費補助金難治性疾患等政策研究事業 (難治性疾患政策研究事業) 「関節リウマチ (RA) や炎症性腸疾患 (IBD) 罹患女性患者の妊娠, 出産を考えた治療指針の作成」研究班 平成28年度~29年度総合研究報告書 (研究代表者 ; 齋藤滋). 2018 : 36-38.
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第5章 参考資料・情報

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