高齢者のための高血圧診療

出版社: 丸善出版
著者:
発行日: 2020-03-30
分野: 臨床医学:内科  >  老人医学
ISBN: 9784621305010
電子書籍版: 2021-02-26 (電子書籍版)
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『高齢者のための』シリーズ第4弾。
高血圧をテーマにEBM(根拠に基づく医療)の大家、名郷直樹医師が、高齢者の定義・ガイドラインや降圧薬の是非・終末期ケアなど、今医師はどういう臨床を提供するべきなのかを解説。第4部の「対談」では、岩田健太郎医師と高血圧診療についてだけでなく、終末期の意思決定や安楽死などの社会情勢と医療を絡めて議論を展開します。

目次

  • 第1部 総論
     1章 高齢化と血圧の関係(リスクとしての高血圧)
     2章 高齢者の高血圧の問題とは何か(さまざまなPECO)
     3章 ガイドラインはどうなっているか(日本のガイドライン、欧米のガイドライン)

    第2部 各論(必須の論文を押さえながら)
     4章 高齢者の血圧に影響する因子とその対応
     5章 高齢者血圧の治療効果
     6章 多様な疾患の中での高血圧治療(糖尿病,慢性腎臓病,二次予防,フレイル)
     7章 高血圧のエビデンスから高血圧の診療へ:個別性から関係性へ
     8章 高齢者高血圧の診療の実際へ向けて

    第3部 極論(世の中のでたらめに一言)
     9章 認知症と高血圧
     10章 血圧が高いと救急外来を受診する高齢者
     11用ポリファーマシーにはこう介入する
     12章 介護施設における高血圧管理(デイサービス,入浴前の血圧測定)
     13章 終末期ケアと血圧(終末期の対応,中止時の不安、低血圧の問題)
     14章 高齢者が血圧を測らない世の中

    第4部 対談
     15章 対談:高血圧編
     16章 対談:意思決定編
     17章 対談:世の中編

    付録 高齢者血圧の勉強法
       (論文を読まずに診療できるのか)

この書籍の参考文献

参考文献のリンクは、リンク先の都合等により正しく表示されない場合がありますので、あらかじめご了承下さい。

本参考文献は電子書籍掲載内容を元にしております。

第1部 総論

P.12 掲載の参考文献
1) 厚生労働省 : 平成29年国民健康・栄養調査報告 (https://www.mhlw.go.jp/stf/seisakunitsuite/bunya/kenkou_iryou/kenkou/eiyou/h29-houkoku.html).
2) Katsuyuki M, Masato N, et al : Epidemiology of Hypertension in Japan-Where Are We Now?. Circ J 2013 ; 77 : 2226-31 (https://www.jstage.jst.go.jp/article/circj/77/9/77_CJ-13-0847/_pdf/-char/ja).
3) Lewington S, Clarke R, et al : Age-specific relevance of usual blood pressure to vascular mortality : a meta-analysis of individual data for one million adults in 61 prospective studies. Lancet. 2002 Dec 14 ; 360 (9349) : 1903-13.
4) Fujiyoshi A, Ohkubo T, et al : Blood pressure categories and long-term risk of cardiovascular disease according to age group in Japanese men and women. Hypertens Res. 2012 Sep ; 35 (9) : 947-53.
5) Murakami Y, Hozawa A, et al : Relation of blood pressure and all-cause mortality in 180,000 Japanese participants : pooled analysis of 13 cohort studies. Hypertension. 2008 Jun ; 51 (6) : 1483-91.
P.21 掲載の参考文献
1) 名郷直樹 (著) : ステップアップEBM実践ワークブック. 南江堂, 2009.
2) Fujiyoshi A, Ohkubo T, et al : Blood pressure categories and long-term risk of cardiovascular disease according to age group in Japanese men and women. Hypertens Res. 2012 Sep ; 35 (9) : 947-53.
P.32 掲載の参考文献
1) https://minds.jcqhc.or.jp/s/guidance_2017_0_h.
2) https://www.jpn-geriat-soc.or.jp/tool/pdf/guideline2017_01.pdf.
3) 日本高血圧学会高血圧治療ガイドライン作成委員会編 : 高血圧治療ガイドライン 2019. ライフサイエンス出版, 2019.
4) Reboussin DM, Allen NB, et al : Systematic Review for the 2017 ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults : A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. Circulation. 2018 Oct 23 ; 138 (17) : e595-e616.
5) Williams B, Mancia G, et al : 2018 ESC/ESH Guidelines for the management of arterial hypertension : The Task Force for the management of arterial hypertension of the European Society of Cardiology and the European Society of Hypertension : The Task Force for the management of arterial hypertension of the European Society of Cardiology and the European Society of Hypertension. J Hypertens. 2018 Oct ; 36 (10) : 1953-2041.
6) 岩田健太郎 (著) : 感染症は実在しない : 構造構成的感染症学. 北大路書房, 2009.

第2部 各論 ( 必須の論文を押さえながら )

P.43 掲載の参考文献
1) Satoh M, Metoki H, et al : Age-Related Trends in Home Blood Pressure, Home Pulse Rate, and Day-to-Day Blood Pressure and Pulse Rate Variability Based on Longitudinal Cohort Data : The Ohasama Study. J Am Heart Assoc. 2019 Aug 6 ; 8 (15) : e012121.
2) 日本高血圧学会高血圧治療ガイドライン作成委員会編 : 高血圧治療ガイドライン 2019. ライフサイエンス出版, 2019.
3) Muntner P, Shimbo D, et al : Measurement of Blood Pressure in Humans : A Scientific Statement From the American Heart Association. Hypertension. 2019 May ; 73 (5) : e35-e66.
4) Barochiner J, Alfie J, et al : Postprandial hypotension detected through home blood pressure monitoring : a frequent phenomenon in elderly hypertensive patients. Hypertens Res. 2014 May ; 37 (5) : 438-43.
5) Wu JS, Yang YC, et al : Population-based study on the prevalence and correlates of orthostatic hypotension/hypertension and orthostatic dizziness. Hypertens Res. 2008 May ; 31 (5) : 897-904.
6) Kawano Y, Abe H, et al : Acute depressor effect of alcohol in patients with essential hypertension. Hypertension. 1992 Aug ; 20 (2) : 219-26.
7) Newton JL, Frith J : The efficacy of nonpharmacologic intervention for orthostatic hypotension associated with aging. Neurology. 2018 Aug 14 ; 91 (7) : e652-e656.
8) Subbarayan S, Myint PK, et al : Nonpharmacologic Management of Orthostatic Hypotension in Older People : A Systematic Review. The SENATOR ONTOP Series. J Am Med Dir Assoc. 2019 May 17. pii : S1525-8610 (19) 30327-5.
9) Kikuya M, Ohkubo T, et al : Day-by-day variability of blood pressure and heart rate at home as a novel predictor of prognosis : the Ohasama study. Hypertension. 2008 Dec ; 52 (6) : 1045-50.
10) Sabayan B, Wijsman LW, et al : Association of visit-to-visit variability in blood pressure with cognitive function in old age : prospective cohort study. BMJ. 2013 Jul 29 ; 347 : f4600.
11) Wijsman LW, de Craen AJ, et al : Blood Pressure Lowering Medication, Visit-to-Visit Blood Pressure Variability, and Cognitive Function in Old Age. Am J Hypertens. 2016 Mar ; 29 (3) : 311-8.
P.58 掲載の参考文献
1) 名郷直樹 : ステップアップEBM実践ワークブック. 南江堂, 2009.
2) Musini VM, Tejani AM,et al : Pharmacotherapy for hypertension in adults 60 years or older. Cochrane Database Syst Rev. 2019 Jun 5 ; 6 : CD000028.
3) Beckett NS, Peters R, HYVET Study Group et al : Treatment of hypertension in patients 80 years of age or older. N Engl J Med. 2008 May 1 ; 358 (18) : 1887-98.
P.77 掲載の参考文献
1) Ninomiya T, Zoungas S,et al : Efficacy and safety of routine blood pressure lowering in older patients with diabetes : results from the ADVANCE trial. J Hypertens. 2010 Jun ; 28 (6) : 1141-9.
2) Emdin CA, Rahimi K,et al : Blood pressure lowering in type 2 diabetes : a systematic review and meta-analysis. JAMA. 2015 Feb 10 ; 313 (6) : 603-15.
3) Cheung AK, Rahman M, et al ; SPRINT Research Group : Effects of Intensive BP Control in CKD. J Am Soc Nephrol. 2017 Sep ; 28 (9) : 2812-23.
4) Williamson JD, Supiano MA, et al ; SPRINT Research Group : Intensive vs Standard Blood Pressure Control and Cardiovascular Disease Outcomes in Adults Aged > 75 Years : A Randomized Clinical Trial. JAMA. 2016 Jun 28 ; 315 (24) : 2673-82.
5) Tsai WC, Wu HY, et al : Association of Intensive Blood Pressure Control and Kidney Disease Progression in Nondiabetic Patients With Chronic Kidney Disease : A Systematic Review and Meta-analysis. JAMA Intern Med. 2017 Jun 1 ; 177 (6) : 792-9.
6) Malhotra R, Nguyen HA, et al : Association Between More Intensive vs Less Intensive Blood Pressure Lowering and Risk of Mortality in Chronic Kidney Disease Stages 3 to 5 : A Systematic Review and Meta-analysis. JAMA Intern Med. 2017 Oct 1 ; 177 (10) : 1498-1505.
7) 日本腎臓学会 (編) : エビデンスに基づくCKD診療ガイドライン 2018. 東京医学社. 2018 (https://cdn.jsn.or.jp/data/CKD2018.pdf).
8) 日本高血圧治療ガイドライン作成委員会 (編) : 高血圧治療ガイドライン 2014. 日本高血圧学会, 2014 (https://www.jpnsh.jp/data/jsh2014/jsh2014v1_1.pdf).
9) Zonneveld TP, Richard E, et al : Blood pressure-lowering treatment for preventing recurrent stroke, major vascular events, and dementia in patients with a history of stroke or transient ischaemic attack. Cochrane Database Syst Rev. 2018 Jul 19 ; 7 : CD007858.
10) Puttnam R, Davis BR, et al ; Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT) Collaborative Research Group : Association of 3 Different Antihypertensive Medications With Hip and Pelvic Fracture Risk in Older Adults : Secondary Analysis of a Randomized Clinical Trial. JAMA Intern Med. 2017 Jan 1 ; 177 (1) : 67-76.
11) Lin SM, Yang SH, et al : Association between diuretic use and the risk of vertebral fracture after stroke : a population-based retrospective cohort study. BMC Musculoskelet Disord. 2019 Mar 4 ; 20 (1) : 96.
12) Warwick J, Falaschetti E, et al : No evidence that frailty modifies the positive impact of antihypertensive treatment in very elderly people : an investigation of the impact of frailty upon treatment effect in the HYpertension in the Very Elderly Trial (HYVET) study, a double-blind, placebo-controlled study of antihypertensives in people with hypertension aged 80 and over. BMC Med. 2015 Apr 9 ; 13 : 78.
P.87 掲載の参考文献
1) Musini VM, Tejani AM,et al : Pharmacotherapy for hypertension in adults 60 years or older. Cochrane Database Syst Rev. 2019 Jun 5 ; 6 : CD000028.
P.97 掲載の参考文献
1) 厚生労働省 : 平成22年度国民健康・栄養調査報告. 平成24年5月 (https://www.mhlw.go.jp/bunya/kenkou/eiyou/dl/h22-houkoku-01.pdf).
2) Tully PJ, Tzourio C : Psychiatric correlates of blood pressure variability in the elderly : The Three City cohort study. Physiol Behav. 2017 Jan 1 ; 168 : 91-7.
3) 平成29年度人生の最終段階における医療に関する意識調査結果 (確定版) (https://www.mhlw.go.jp/file/05-Shingikai-10801000-Iseikyoku-Soumuka/0000200749.pdf).
4) Kostis JB, Cabrera J, et al : Association between chlorthalidone treatment of systolic hypertension and long-term survival. JAMA. 2011 Dec 21 ; 306 (23) : 2588-93.

第3部 極論 ( 世の中のでたらめに一言 )

P.115 掲載の参考文献
1) Staessen JA, Thijs L, et al : Placebo-controlled trials of blood pressure-lowering therapies for primary prevention of dementia. Hypertension. 2011 Feb ; 57 (2) : e6-7.
2) Zonneveld TP, Richard E, et al : Blood pressure-lowering treatment for preventing recurrent stroke, major vascular events, and dementia in patients with a history of stroke or transient ischaemic attack. Cochrane Database Syst Rev. 2018 Jul 19 ; 7 : CD007858.
3) SPRINT MIND Investigators for the SPRINT Research Group, Williamson JD, et al : Effect of Intensive vs Standard Blood Pressure Control on Probable Dementia : A Randomized Clinical Trial. JAMA. 2019 Feb 12 ; 321 (6) : 553-61.
4) Montori VM, Devereaux PJ, et al : Randomized trials stopped early for benefit : a systematic review. JAMA. 2005 Nov 2 ; 294 (17) : 2203-9.
5) Forette F, Seux ML, et al : The prevention of dementia with antihypertensive treatment : new evidence from the Systolic Hypertension in Europe (Syst-Eur) study. Arch Intern Med. 2002 Oct 14 ; 162 (18) : 2046-52.
6) Ninomiya T, Ohara T, et al : Midlife and late-life blood pressure and dementia in Japanese elderly : the Hisayama study. Hypertension. 2011 Jul ; 58 (1) : 22-8.
7) Walker KA, Sharrett AR, et al : Association of Midlife to Late-Life Blood Pressure Patterns With Incident Dementia. JAMA. 2019 Aug 13 ; 322 (6) : 535-45.
8) Mossello E, Pieraccioli M, et al : Effects of low blood pressure in cognitively impaired elderly patients treated with antihypertensive drugs. JAMA Intern Med. 2015 Apr ; 175 (4) : 578-85.
9) Qiu C, von Strauss E, et al : Low blood pressure and risk of dementia in the Kungsholmen project : a 6-year follow-up study. Arch Neurol. 2003 Feb ; 60 (2) : 223-8.
10) Moonen JE, Foster-Dingley JC, et al : Effect of Discontinuation of Antihypertensive Treatment in Elderly People on Cognitive Functioning--the DANTE Study Leiden : A Randomized Clinical Trial. JAMA Intern Med. 2015 Oct ; 175 (10) : 1622-30.
11) 日本高血圧学会高血圧治療ガイドライン作成委員会編 : 高血圧治療ガイドライン 2019. ライフサイエンス出版, 2019.
P.122 掲載の参考文献
1) Beckett NS, Peters R, et al ; HYVET Study Group : Treatment of hypertension in patients 80 years of age or older. N Engl J Med. 2008 May 1 ; 358 (18) : 1887-98.
2) 日本高血圧学会高血圧治療ガイドライン作成委員会編 : 高血圧治療ガイドライン 2019. ライフサイエンス出版, 2019.
3) Nobile-Orazio E, Sterzi R : Cerebral ischaemia after nifedipine treatment. Br Med J (Clin Res Ed). 1981 Oct 10 ; 283 (6297) : 948.
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5) Miller JL : FDA committee recommends stronger warnings against inappropriate use of immediate-release nifedipine. Am J Health Syst Pharm. 1996 Mar 15 ; 53 (6) : 599-600.
6) Psaty BM, Heckbert SR, et al : The risk of myocardial infarction associated with antihypertensive drug therapies. JAMA. 1995 Aug 23-30 ; 274 (8) : 620-5.
7) Furberg CD, Psaty BM, et al : Nifedipine. Dose-related increase in mortality in patients with coronary heart disease. Circulation. 1995 Sep 1 ; 92 (5) : 1326-31.
P.132 掲載の参考文献
1) Sato I, Akazawa M : Polypharmacy and adverse drug reactions in Japanese elderly taking antihypertensives : a retrospective database study. Drug Healthc Patient Saf. 2013 Jun 24 ; 5 : 143-50.
2) Budnitz DS, Lovegrove MC, et al : Emergency hospitalizations for adverse drug events in older Americans. N Engl J Med. 2011 Nov 24 ; 365 (21) : 2002-12.
3) Gomez C, Vega-Quiroga S, et al : Polypharmacy in the Elderly : A Marker of Increased Risk of Mortality in a Population-Based Prospective Study (NEDICES). Gerontology. 2015 ; 61 (4) : 301-9.
4) Lu WH, Wen YW, et al : Effect of polypharmacy, potentially inappropriate medications and anticholinergic burden on clinical outcomes : a retrospective cohort study. CMAJ. 2015 Mar 3 ; 187 (4) : E130-E137.
5) Rankin A, Cadogan CA, et al : Interventions to improve the appropriate use of polypharmacy for older people. Cochrane Database Syst Rev. 2018 Sep 3 ; 9 : CD008165.
6) Thillainadesan J, Gnjidic D, et al : Impact of Deprescribing Interventions in Older Hospitalised Patients on Prescribing and Clinical Outcomes : A Systematic Review of Randomised Trials. Drugs Aging. 2018 Apr ; 35 (4) : 303-19.
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8) van der Wardt V, Harrison JK, et al : Withdrawal of antihypertensive medication : a systematic review. J Hypertens. 2017 Sep ; 35 (9) : 1742-49.
9) Musini VM, Tejani AM, et al : Pharmacotherapy for hypertension in adults 60 years or older. Cochrane Database Syst Rev. 2019 Jun 5 ; 6 : CD000028.
P.144 掲載の参考文献
1) Odden MC, Peralta CA, et al : Rethinking the association of high blood pressure with mortality in elderly adults : the impact of frailty. Arch Intern Med. 2012 Aug 13 ; 172 (15) : 1162-8.
2) Benetos A, Labat C, et al : Treatment With Multiple Blood Pressure Medications, Achieved Blood Pressure, and Mortality in Older Nursing Home Residents : The PARTAGE Study. JAMA Intern Med. 2015 Jun ; 175 (6) : 989-95.
3) Radholm K, Festin K, et al : Blood pressure and all-cause mortality : a prospective study of nursing home residents. Age Ageing. 2016 Nov ; 45 (6) : 826-32.
4) 日本高血圧学会高血圧治療ガイドライン作成委員会編 : 高血圧治療ガイドライン 2019. ライフサイエンス出版, 2019.
5) 日本老年医学会編 : 高齢者高血圧診療ガイドライン 2017.
6) Rutan GH, Hermanson B, et al : Orthostatic hypotension in older adults. The Cardiovascular Health Study. CHS Collaborative Research Group. Hypertension. 1992 Jun ; 19 (6 Pt 1) : 508-19.
7) Barochiner J, Alfie J, et al : Postprandial hypotension detected through home blood pressure monitoring : a frequent phenomenon in elderly hypertensive patients. Hypertens Res. 2014 May ; 37 (5) : 438-43.
8) Fujiwara T, Hoshide S, et al : Difference in evening home blood pressure between before dinner and at bedtime in Japanese elderly hypertensive patients. J Clin Hypertens (Greenwich). 2017 Jul ; 19 (7) : 731-9.
9) Gibbons CH, Freeman R : Delayed orthostatic hypotension : a frequent cause of orthostatic intolerance. Neurology. 2006 Jul 11 ; 67 (1) : 28-32.
10) Onrot J, Goldberg MR, et al : Hemodynamic and humoral effects of caffeine in autonomic failure. Therapeutic implications for postprandial hypotension. N Engl J Med. 1985 Aug 29 ; 313 (9) : 549-54.
11) Subbarayan S, Myint PK, et al : Nonpharmacologic Management of Orthostatic Hypotension in Older People : A Systematic Review. The SENATOR ONTOP Series. J Am Med Dir Assoc. 2019 Sep ; 20 (9) : 1065-73.e3.
12) Shannon JR, Diedrich A, et al : Water drinking as a treatment for orthostatic syndromes. Am J Med. 2002 Apr 1 ; 112 (5) : 355-60.
P.153 掲載の参考文献
1) Odden MC, Peralta CA, et al : Rethinking the association of high blood pressure with mortality in elderly adults : the impact of frailty. Arch Intern Med. 2012 Aug 13 ; 172 (15) : 1162-8.
2) Benetos A, Labat C, et al : Treatment With Multiple Blood Pressure Medications, Achieved Blood Pressure, and Mortality in Older Nursing Home Residents : The PARTAGE Study. JAMA Intern Med. 2015 Jun ; 175 (6) : 989-95.
3) Radholm K, Festin K, et al : Blood pressure and all-cause mortality : a prospective study of nursing home residents. Age Ageing. 2016 Nov ; 45 (6) : 826-32. Epub 2016 Jul 18.
4) https://www.mhlw.go.jp/shingi/2010/05/dl/s0531-13d_03.pdf.
5) https://www.mhlw.go.jp/toukei/saikin/hw/life/life17/dl/life17-06.pdf.
6) https://www.mhlw.go.jp/toukei/saikin/hw/life/life17/dl/life17-07.pdf.
P.162 掲載の参考文献
1) Williamson JD, Supiano MA, et al ; SPRINT Research Group : Intensive vs Standard Blood Pressure Control and Cardiovascular Disease Outcomes in Adults Aged > 75 Years : A Randomized Clinical Trial. JAMA. 2016 Jun 28 ; 315 (24) : 2673-82.
2) Lin SM, Yang SH, et al : Association between diuretic use and the risk of vertebral fracture after stroke : a population-based retrospective cohort study. BMC Musculoskelet Disord. 2019 Mar 4 ; 20 (1) : 96.

第4部 対談

P.174 掲載の参考文献
1) https://www.framinghamheartstudy.org.
2) Reboussin DM, Allen NB, et al : Systematic Review for the 2017 ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults : A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. Circulation. 2018 Oct 23 ; 138 (17) : e595-e616 (https://www.ahajournals.org/doi/pdf/10.1161/CIR.0000000000000601).
3) Williams B, Mancia G, et al : 2018 ESC/ESH Guidelines for the management of arterial hypertension : The Task Force for the management of arterial hypertension of the European Society of Cardiology and the European Society of Hypertension : The Task Force for the management of arterial hypertension of the European Society of Cardiology and the European Society of Hypertension.J Hypertens. 2018 Oct ; 36 (10) : 1953-2041.
4) https://www.jpn-geriat-soc.or.jp/tool/pdf/guideline2017_01.pdf.
5) 日本高血圧学会高血圧治療ガイドライン作成委員会編 : 高血圧治療ガイドライン 2019. ライフサイエンス出版, 2019.
6) Kostis JB, Cabrera J, et al : Association between chlorthalidone treatment of systolic hypertension and long-term survival. JAMA. 2011 Dec 21 ; 306 (23) : 2588-93.
7) 岩田健太郎 (監修・著), 岩岡秀明ほか (著) : 高齢者のための糖尿病診療. 丸善出版, 2019.
P.183 掲載の参考文献
1) https://honkawa2.sakura.ne.jp/1615.html.
2) 矢崎義雄 (総編集), 島田和幸 (編) : 臨床高血圧 (普及版). 朝倉書店, 2012.
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1) 宮野真生子, 磯野真穂 : 急に具合が悪くなる. 晶文社, 2019.
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付録 高齢者高血圧の勉強法 ( 論文を読まずに診療できるのか )

P.205 掲載の参考文献
1) UpToDate (https://www.uptodate.com/ja/home).
2) DynaMed (https://www.ebsco.com/ja-jp/products/dynamed).
3) 今日の臨床サポート (https://clinicalsup.jp).
4) EvidenceAlerts (https://www.evidencealerts.com).
5) 名郷直樹 (著) : 続EBM実践ワークブック─今, できる限りの医療を. 南江堂, 2002 : 177-85.
6) EBM-Tokyo (http://ebm.umin.ne.jp).
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10) Musini VM, Tejani AM, et al : Pharmacotherapy for hypertension in adults 60 years or older. Cochrane Database Syst Rev. 2019 Jun 5 ; 6 : CD000028.
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12) PubMed (https://www.ncbi.nlm.nih.gov/pubmed).
13) 東京大学医学図書館PubMedの使い方 (https://www.lib.m.u-tokyo.ac.jp/manual/pubmedmanual.pdf).
14) Mindsガイドラインライブラリ (https://minds.jcqhc.or.jp).
15) CMECジャーナルクラブ (https://cmec.jp).
16) 高血圧のエビデンス 2017 (https://cmec.jp/cover/201710).
17) 名郷直樹 (著) : ステップアップEBM実践ワークブック. 南江堂, 2009.

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