Cyto-protection ＆ biology Vol.11 1993年 第11回 サイトプロテクション研究会

出版社： 癌と化学療法社
著者：
発行日： 1993-11-30
分野： 臨床医学：基礎  >  臨床細胞学
ISSN： 0289-368
電子書籍版： 1993-11-30
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1993年　第11回　サイトプロテクション研究会。当研究会も、十年を超えた今年から新しい出発の一歩を踏み出した。

目次

  • 表紙
  • 序文
  • 目次
  • 特別寄稿
  • 生物の内景と活性酸素代謝
  • 特別講演
  • 細胞レベルからみた消化管粘膜の防御機構
  • Session 胃粘膜障害
  • 座長所感
  • 急性潰瘍発生時における胃粘膜血流について
  • H2受容体拮抗剤投与後の幽門腺ガストリン細胞数, 血中ガストリン値, 胃内pHの変化
  • 免疫抑制剤によるストレス潰瘍発生の抑制
  • 胃粘膜表層上皮細胞の酸塩基障害に対する細胞内pH調節能
  • Session 消化管障害
  • 座長所感
  • 胃潰瘍病変形成における顆粒球エラスターゼの関与とその制御
  • 胃幽門洞粘膜における粘液分泌
  • 培養胃粘膜細胞を用いた新しい定量的wound-repairモデル
  • 小腸粘膜防御としての粘膜アルカリフォスファターゼ (ALP) の意義
  • ラット小腸移植における脾抽出物あるいは小腸抽出物投与の意義
  • Session 肝I
  • 座長所感
  • 虚血・再灌流性肝障害時におけるKupffer細胞の関与
  • 虚血肝のエネルギー水準低下に対する薬剤の防御効果
  • 胆汁うっ滞性障害肝におけるinsulinおよびglucagon代謝とそれに及ぼす温阻血とCoQ10の影響
  • Session 肝II
  • 座長所感
  • Kupffer細胞の生体防御機構における役割 ―特にnitric oxideを介した抗腫瘍活性について―
  • Prostaglandin I2誘導体の肝細胞保護作用とその機序
  • In vitroガラクトサミン肝障害に対するEGFの効果
  • 常温下人工心肺灌流法を用いた, 心停止ドナーからの肝移植の可能性の検討
  • Session 脳
  • 座長所感
  • Nicardipineの虚血脳における局所脳血流, Na+-K+-ATPase活性および水分含有量に与える効果について
  • 実験的頭部外傷急性期に対するソルコセリル注の効果 ―自発的行動監視装置を用いて―
  • 慢性硬膜下血腫の定量的脳波分析および脳血流量との相関
  • 痴呆患者における髄液中葉酸値とビタミンB12活性値の臨床的意義
  • ヒト脳腫瘍における組織内グルタチオンの定量的解析および蛍光組織化学的検討
  • Session 細胞
  • 座長所感
  • 白血球の阻血再灌流時の膵機能に及ぼす影響
  • 血管内皮細胞障害とapoptosis/necrosis
  • TNFによる血管内皮細胞barrier function障害作用に対するcyclic AMPの影響とその制御
  • Session 心・肺・膵
  • 座長所感
  • 長期間40%酸素曝露モルモット肺におけるヒドロキシプロリン量およびコラゲナーゼ活性の検討
  • ラット・セルレイン急性膵炎に対するurinastatinおよびloxiglumideの治療効果
  • ラットでの総膵胆管閉塞・外分泌刺激・膵虚血モデルにおける尿中トリプシン阻害剤, ウリナスタチンの膵保護効果について
  • Session フリーラジカル
  • 座長所感
  • 保存肺の再灌流障害におけるPAF拮抗剤 (TCV-309) の有用性の検討
  • 人工血液再灌流による脱血ショック時の胃粘膜病変と活性酸素の検討
  • 閉塞性黄疸時の急性胃粘膜障害発生における活性酸素の関与に関する実験的検討
  • 肝虚血―再灌流におけるフリーラジカルの産生とIL-1の関与
  • 研究会会則
  • 奥付

この書籍の参考文献

参考文献のリンクは、リンク先の都合等により正しく表示されない場合がありますので、あらかじめご了承下さい。

本参考文献は電子書籍掲載内容を元にしております。

特別寄稿

P.7 掲載の参考文献
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特別講演

P.15 掲載の参考文献
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2) Chew CS, Nakamura K and Petropoulos AC : Characterization of acid secretory responsiveness of cultured gastric glands. J. Cell Biol. 115 : 401a, 1991.
 
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4) Rovert A, Eberle D, and Kaplowitz N : Role of glutathione in gastric mucosal cytoprotection. Am. J. Physiol. 247 : G296-304, 1984.
 
5) Rokutan K, Thomas JA and Sies H : Specific S-thiolation of a 30 kDa cyto-solic protein from liver under oxidative stress. Eur. J. Biochem. 179 : 233-239, 1989.
 
6) Rokutan K, Thomas JA and Johnston RBJr. : Phago-ocytosis and stimulation of the respiratory burst by phorbor diester initiates S-thiolation of specific proteins in macrophages. J. Immunol. 147 : 260-264, 1991.
 
7) 六反一仁 : Oxidative stressにおける細胞骨格の修飾. 医学のあゆみ 157 : 270-273, 1991.
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8) Rokutan K, Johnston RB Jr. and Kawai K : Oxida-tive stress induces S-thiolation of specific proteins in cultured gastric mucosal cells. Am. J. Physiol. (in press).
 
9) Nakamura K, Rokutan K, Marui N, et al : Induction of heat shock proteins and their implication in protection against ethanol-induced damage in cultured guinea pig gastric mucosal cells. Gastroenterology 101 : 161-166, 1991.
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10) 六反一仁 : ストレス蛋白と胃病変. Mebio 9(9) : 66-71, 1991.
 
11) 六反一仁 : 胃粘膜の分化, 増殖と受容体. GI Reserch 1 (1) : 61-67, 1993.
 
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13) Folkman J, Szabo S, Stovroff M, et al : Duodenal ulcer. Ann. Surg. 214 : 414-427, 1991
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14) Tarnawski A, Stachura J, Durbin T, et al : Increased expression of epidermal growth factor receptor during gastric ulcer healing in rats. Gastroenterology 102 : 695-698, 1992.
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15) Ullrich A and Schlessinger J : Signal transduc-tion by receptors with tyrosine kinase activity. Cell 61 : 203-212, 1990.
 
16) Carpenter G and Cohen S : Epidermal growth factor. J. Biol. Chem. 265 : 7709-7712, 1991.
 
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Session 胃粘膜障害

P.22 掲載の参考文献
1. 長畑洋司, 裏川公章 : ストレス潰瘍発生過程におけるドパミンの役割についての実験的研究. 日消誌 83 : 1289-1297, 1986
 
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5. 林民樹, 裏川公章, 斉藤洋一 : ストレス潰瘍の発生機序に関する実験的研究. 日外会誌 87 : 1414-1421, 1986
 
6. Nagahata Y, Kuroda H, Idei H, et al : Patho genesis of acute gastric ulcer on the changes of catecholamines in hypothalamus and gastric mucosa. Cytoprotection and Cytobiology, 9 : 55-60, 1992
 
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8. Nagahata Y, Urakawa T, Azumi Y, et al : Effects of kinds of anti-ulcer drugs on gastric microcirculation. Cytoprotection and Cytobiology. 7 : 81-87, 1989
 
P.26 掲載の参考文献
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4) 福地康紀, 柏木秀幸, 青木照明・他 : H2受容体拮抗剤長期投与のラット血清ガストリン値および幽門洞ガストリン細胞数に与える影響について, Ther.Res. 10 : 263-267, 1989.
 
P.30 掲載の参考文献
1) Kuroiwa M, Sugiyama S, GotoH, et al. : The role ofmucosal prostaglandinlevels inhealing of water immersion-induced gastric Ulcers in rats. Scand J Gastroenterol 25 : 59-65, 1990.
 
2) Ohara A, Sugiyama S, Kuroiwa M, et al. : Role of leukotrienes in the genesis and healing of water immersion stress-induced gastric ulcers in rats, Biochem Int 23 : 1055-1062, 1991.
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3) Wallace JL, Keenan CM, Mugridge KG, et al. : Reduction of the severity of experimental gastric and duoden al ulceration by interleukin-1β. Eur J Pharmacol 186 : 279-284, 1990.
 
4) Kino T, Hatan akaH, Miyata S, et al. : FK-506, a novel immunosuppressant isolated from a Streptomyces. J Antibiot (Tokyo)40 : 1256-1265, 1987.
 
5) Goto H Nakazawa S, Ozawa T : Decreased levels of prostaglandins I2 and E2 in acute gastric mucosal lesions induced by hypoxia. Biochem Int 14 : 311-317, 1987.
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6) Akaike T, Ando M, Oda T, Doi T, et al. : Dependence on O2-generation by xanthine oxidase of pathogenesis of influenza virus infection in mice. J Clin Invest 85 : 739-745, 1990.
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7) Krawisz JE, Sharon P, Stenson WF : Quantitative assay for acute intestinal inflammation based on myeloperoxidase activity. Gastroenterology 87 : 1344-1350, 1984.
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8) Tarnasky PR, Livingston EH, Jacobs KM, et al. : Role of oxyradicals in cold water immersion restraint-induced gastric mucosal injury in the rat. Dig Dis Sci 35 : 173-177, 1990.
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9) Kobayashi H, Nonami T, Kurokawa T, et al. : Mechanism and prevention of ischemia-reperfusion-induced liver injury in rats. J Surg Res 51 : 240-244, 1991.
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10) Rubin JT, Lotze MT : Acute gastric mucosal injury associated with the systemic administration of interleukin-4. Surgery 111 : 274-280, 1992.
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11) Mezey E, Palkovits M : Localization of targets for anti-ulcer drugs in cells of the lmmune system. Science 258 : 1662-1665, 1992.
 
P.34 掲載の参考文献
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Session 消化管障害

P.40 掲載の参考文献
1. 岡嶋研二 血液凝固異常における好中球の役割 代謝, 29, 51-60, 1992.
 
2. 岡嶋研二 消化性潰瘍とプロテアーゼインヒビター 消化器病セミナー 52, 1993(印刷中).
 
3. Okajima, K., Inoue, M., Koga, S., Okabe, H.and Takatsuki, K. Plasma polymorpho-nuclear leukocytc elastase-alpha-1-proteinase inhibitor complex in patients with gastric ulcer. Clin Chim Acta, 189, 237-242, 1990.
 
P.44 掲載の参考文献
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P.46 掲載の参考文献
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P.50 掲載の参考文献
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P.54 掲載の参考文献
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2) Atkinson DE (1968)The energy charge of the adenylate pool as a regulatory parameter. Interaction with feedback modifiers. Biochemistry 7, 4030-4034.
 
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5) Cosimi AB et al (1981)Use of monoclonal antibodies to T-cell subsets for immunolo-gic motoring and treatment in recipients of renal allografts. N Engl J Med 305, 308-314.
 
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Session 肝I

P.63 掲載の参考文献
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5) 中島年和, 中嶋俊彰, 島 俊英・他 : 表面コイル31P-NMR法によるラット障害肝のエネルギー代謝の解析. 肝臓 27 : 1475, 1986.
 
6) 酒井基成, 中嶋俊彰, 中島年和・他 : ラット灌流肝のATPレベルとICG移送についての検討. 薬理と治療 20 : 127-131, 1992.
 
7) 中島年和, 中嶋俊彰, 阪本善邦・他 : 外因性ATPのラット肝エネルギー代謝と胆汁分泌動態におよぼす影響. 日本臨床代謝学会記録(XXV) 224-225, 1988.
 
8) 中嶋俊彰, 中島年和, 瀬戸良文・他 : 虚血肝エネルギー代謝に対するタウリンの保護作用. 肝臓 28 : 266, 1987.
 
9) 中島年和, 中嶋俊彰, 瀬戸良文・他 : ラット灌流肝における虚血, 低酸素条件下のエネルギー代謝に対するtaurineの効果-31P-NMR法を用いた検討. 含硫アミノ酸 10 : 259-264, 1987.
 
10) Nakashima T, Seto Y, Nakajima T, et al : Calcium-assoclated cytoprotective effect of taurlne on the calcium and oxygen paradoxes ln isolated rat hepatocytes. Liver 1O : 167-72, 1990.
 
P.68 掲載の参考文献
1) Huguet C, Nordlinger B, Bloch P et al : Tolerance of the human liver to prolonged normothermic ischemia. Arch Surg 113 : 1448-1451, 1978
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2) Feindel, C. M., Harper, R., Wallace, A. C., et al : Tolerance of the liver to ischemia. Can. J. Surg., 24 : 147, 1982
 
3) Fornander, J., Seeman, T. and Fasselgren, P. o. : Changes of protein synthesis in liver tissue following ligation of hepatic arteryor portal vein in rats. Eur. Surg. Res., 17 : 101, 1985
 
4) 宮崎 勝, 伊東 博, 神野 弥生, 他 : 肝細胞障害. 肝と膵, 12 : 5-9, 1991
 
5) Kuroda, T., Yamagishi, K., Iwatsuki, K., etal : Mechanism of pancreatic hyper secretion in dogs with obstructive jaundice. Int. J. Pancreaol., 2 : 425-436, 1988
 
6) 梶川 昌二, 黒田 孝井, 山岸喜代文, 他 : 閉塞性黄疸時のインスリン動態. 医学のあゆみ, 150 : 627, 1989
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7) 大内 清昭, 松原 修二, 竹藤大成, 他 : 肝流入血行 遮断下での閉塞性黄疸肝切除後早期の病態. : 日消誌, 88 : 1216-1220, 1991
 
8) 花崎 和弘 : 温阻血に伴う肝代謝異常とその対策. : 日外会誌, 93 : 274-287, 1992
 
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10) 伊東 博, 宮崎 勝, 宇田川 邦夫, 他. : 閉塞性黄疸肝における阻血再灌流浸襲時の肝細胞障害に関する基礎的研究, : 日消誌, 88 : 1200-1207, 1991
 

Session 肝II

P.74 掲載の参考文献
1) Kurose I, Saito M, Suematsu M, et al : Kupffer cell-mediated oxidative stress on colon cancer cell line visualized by digital imaging fluorescence microscopy. Cancer Lett. 59 : 201-209, 1991.
 
2) Yonei Y, Kurose I, Fukumura D, et al : Evidence of direct interaction between Kupffer cells and colon cancer cells : an ultrastructural study of the co-culture. Liver (in press).
 
3) Hibbs JB, Taintor RR, Vavrin Z, et al : Nitric oxide : a cytotoxic activated macro-phage effector molecule. Biochem. Biophys. Res. Commun. 157 : 87-94, 1988.
 
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5) Kurose I, Kato S, Ishii H, et al : Nitric oxide mediates lipopolysaccharide-induced alteration of mitochondrial function in cultured hepatocytes and isolated-perfused liver. Hepatology 18 : 380-388, 1993.
PubMed
6) Kurose I, Miura S, Fukumura D, et al : Nitric oxide mediates Kupffer cell-induced reduction of mitochondrial energization in hepatolma cells : a comparison with oxidative burst. Cancer Res. 53 : 2676-2682, 1993.
 
P.78 掲載の参考文献
1) Seglen PO : Preparation of Isolated Rat Livcr Cells. Methods in Cell Biology. 13 : 29-83, 1976
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2) Grynkiewicz G, Poenie M, Tsien RY : A New Generation of Ca2+ Indicators with Greatly Improved Fluorescence Properties. J. Biol. Chem. 260 : 3440-3450, 1985
PubMed
3) Murata M, Monden M, Umeshita K, et al : Role of cytosolic free calci um in free radical-mediated hepatocytes injury. Cytoprotection and cytobiology. 10 : 108-113, 1992
 
4) Thurman RG, Marzi I. Seitz G, et al : Hepatic reperfusion injury following orthotopic liver transplantation in the rat. Transplantation. 46 : 502-506, 1988
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5) Jaeschke H, Farhood A : Neutrophiles and Kupffer cell-induced oxidant stress and ischemia-reperfusion injury in rat liver. Am. J. Physiol. 260 : G355-362, 1991
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6) Monden M, Fortner JG : Twenty-four-and 48-hour Canine Liver Preservation by Simple Hypothermia with Prostacyclin. Ann. Surg.196 : 38-42, 1982
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7) Sikujara O, Monden M, Toyoshima K : Cyto-protective effect of prostaglandin 12 on ischemia-induced hepaticcell injury. Transplantation. 36 : 238-243, 1983
 
8) Schane FAX, Kane AB, Young EB, et al : Calcium Dependence of Toxic Cell Death : A Final Common Pathway : Science. 206 : 700-702, 1979
 
9) Nicotera P, McConkey D, Akesvensson S, et al : Correlation between cytosolic Ca2+ concentration and cytotoxicity in hepatocytes exposed to oxidative stress. Toxicology. 52 : 55-63, 1988
 
10) Geeraerts MD, Ronveaux-Dupal M-F, Lemasters JJ, et al : Cytosolic free Ca2+ and proteolysis in lethal oxidative injury in endothelial cells. : Am. J.Physiol. 261 : 889-896, 1991
 
P.82 掲載の参考文献
1) 稲垣 豊, 小林健一, 服部 信・他 : D-galactosamine投与急性肝不全ラットに対するepidermal growth factor投与効果. 肝臓 28 : 551-555, 1987
 
2) 片村 宏, 杉山 貢, 土屋周二・他 : 実験肝不全におけるEpidermal Growth Factorの効果. Therapeutic Research 10 : 336-341, 1989
 
3) Berry MN and Friend DS : High yield preparation of isolated rat liver parenchymal cells. J. Cell Biol. 43 : 506-520, 1969
 
4) El-Mofty SK, Scrutton MC and Farber JL et al : Early reversible plasma membrane injury in galactosamine induced liver cell death. Am. J. Pathol.79 : 579-595, 1975
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5) Freidenberg Ma, Keppler D and Galanos C : Requirement for lipopolysaccharide-responsible macrophages in galactosamine-induced sensetization to endotoxin. Infect. Immun. 51 : 891-895, 1986
 
6) Leihr H, Grum M and Seeling HP : On the pathogenesis of galactosamine hepatitis. Indication of extrahepatocelluar mechanisms responsible for liver cell death. Virchow Arch. B 26 : 244-331, 1978
 
P.86 掲載の参考文献
1) BG Ericzon, G Lundgren, H Wilczek et al : Experience with human liver grafts obtained after donor cardiac standstill. Transplantation Proc.19, : 3862-3863, 1987
 
2) 関口敦, 小山勇, 星野高伸・他 .摘出臓器保護のための体外循環法-心停止後肝に対する酸素供給, 中心冷却法の試み 体外循環技術 4月, 1990
 
3) Atkinson DE : The energy charge of the adenylate pool as a regulator parameter. Interaction with feedback modifiers. Biochemistry 7 : 4030-4034, 1968.
 
4) Shneider WC and Hogeboom GH : Intracellular distribution of enzimes. V.Further studies on the distribution of cytochrome c in rat studies on the distribution of cytochrome c in rat liver homogenate. : J. Biol ; Chem., 195 : 265, 1951.
 
5) 瀬谷和彦, 大河内信弘, 遠藤忠雄・他 : Mitochgondrial proton ATPase活性の簡便な測定法の開発 : 第10回 生体成分の分析化学シンポ 講演要旨 京都 p.9-12, 1992
 
6) 遠藤忠雄, 大河内信弘, 瀬谷和彦・他 : 常温下人工心肺灌流法を用いた心停止ドナー肝のグラフトコンディショニング. 日移植学会誌 : 27 第28回総会抄録集 365, 1992.
 

Session 脳

P.92 掲載の参考文献
1) Takenaka T, Usuda S, Nomura T, et al : Vasodilator profile of a new 1,4-dihydropyridine derivative, 2,6-dimethyl-4-(3-nitro-phenyl)-1,4-dihydropyridine-3,5-dicarboxy-lic acid 3-12-(N-benzyl-N-methylamino)-ethyl eater 5-methyl ester hydrochloride (YC-93). Arzneim-Forsch. 26 : 2172-2178, 1976.
 
2) Furui T and Iwata K : Effects of opioids on the ischemic brain : simultaneous measurement of cerebral Na+ -K+ -ATPase activity and vasoactive intestinal polypeptide, in Tobe T (ed) : Cytoprotection and Cytobiology. Tokyo, Kanishobo, 1990, pp.275-283.
 
3) Furui T and Iwata K : Alterations of Na+ -K+ -ATPase activity in the acute ischemic brain, in Yunoki K(ed) : Cytoprotection and Cytobi ology. Excerpta Medica, Tokyo, 1991, pp.128-131.
 
4) Schannen FAX, Kane AB. Young EE, et al : Calcium dependence of toxic cell death : a final common pathway. Science 206 : 700-702, 1979.
 
5) Hadani M, Young W and Flamm ES : Nicardipine reduces calcium accumulation and electrolyte derangements in regional cerebral ischemia in rats. Stroke 19 : 1125-1132, 1988.
 
6) Marzatico F, Gaetani P, Spanu G, et al : Effects of nicardipine treatment on Na+-K+-ATPase and lipid peroxidation after experimental subarachnoid haemorrhage. Acta Neurochir. 108 : 128-133, 1991.
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7) Palmer cc, Palmer SJ and Christie-Pope BC : Protective action of calcium channel blockers on Na+-K+-ATPase in gerbil cerebral cortex following ischemia. J. Neurosci Res. 19 : 252-257, 1988.
 
P.96 掲載の参考文献
1) Dixon CE, Leyth BG, Povlishock, et al : A fluid percussion model of experimental brain injury in the rat, J Neurosurg 67 : 110-119, 1987.
 
2) 王 運杰, 小林士郎, 朝倉隆之・他 : ラット重症頭部外傷モデルの検討. 神経外傷 15 : 255, 1992(抄録)
 
3) 志村俊郎, 星野 茂, 小林士郎・他 : ラット重症脳損傷モデルにおける実験病理学的研究. 第16回日本神経外傷研究会, 1993, 東京.
 
4) 河野輝昭, 堤 圭介, 三宅仁志・他 : 虚血性脳浮腫に対する幼牛血液抽出物の効果. Cyto-protection & biology 4 : 117-126, 1986
 
5) 荒木五郎 : 脳血管障害急性期例に対するソルコセリル注の使用経験. 基礎と臨床 8(13) : 4208-4214, 1974
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6) Hirata K, Kawano T, Mori K : Solcoseryl improves the disturbance in brainstem monoamine metabolism which occurs after experimental subarachnoid hemorrhage in rats as measured by in vivo microdialysis. Cyto-protection & biology 9 : 163-170, 1991
 
P.100 掲載の参考文献
1) 楠元和博 小林栄喜 山本国光 三原忠紘 朝倉哲彦 : 慢性硬膜下血腫のCTと脳波50例の検討. 臨床脳波 23 : 720-726, 1981
 
2) Nagata K, Gross CB, Kindt GW. Geier JM Adey GR : Topographic electroencephal-ographic study with power ratio index mapping in patients with malignant brain tumors. Neurosurgery 17(4) : 613-61 9, 1985.
 
3) Nagata K : Topographic EEG in brain ischemaia-correlation with blood flow and metabolism. Brain Topography 1 : 97-106, 1988.
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4) Rodin EA, Bickford RG, Svien HJ : Elect roencephalographic findings associated with subdural hematoma. Arch Neurol Psyhiat 169 : 743-755. 1953.
 
5) Tanaka A, Yoshinaga S, Kimura M : Xenon-enhanced computed tomographic measurement of cerebral blood flow in patients with chronic subdural hematomas. Neurosurgery 27 : 554-561. 1990.
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P.104 掲載の参考文献
1) Bottiglieri T, Hyland K, Laundry M, et al : Folate deficiency, biopterin and monoamine metabolism in depression.Psychol. Med.22 : 871-876, 1992.
 
2) Botez MI, Young SN, Bachevalier J, et al : Effect of folic acid and cerebrospinal fluid. Ann. Neurol.12 : 479-484, 1982.
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3) Young SN and Ghadirian AM : Folic acid and psychopathology. Prog.Neuropsychopharmacol. Biol. Psychiatry 13 : 841-863, 1989.
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4) 宇高不可思, 重松一生, 澤田秀幸・他 : 老人性痴呆とビタミンB12. 臨床成人病 19 : 1213-1215, 1989.
 
5) Ikeda T, Yamamoto K, Takahashi K, et al : Treatment of Alzheimer-type dementia with intravenous Mecobalamin. Clinical Therapeutics 14 : 426-437, 1992.
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6) 田中信夫, 稲葉 敏, 坂戸秀吉・他 : Radioassay法による血中ビタミンB12および葉酸同時測定法の基礎的・臨床的検討. 核医学 22 : 929-938, 1985.
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7) Hunter RJ, Barnes G, Curzon BD, et al : Effect of folic acid by mouth on cerebrospinal fluid homovanillic acid and 5-hydroxyindoleacetic acid concentration. J. Neurol. Neurosurg. Psychiatry 34 : 571-575, 1971.
 
8) Show DMDA, Macsweency al, Johnson R, et al : Folate and amine metabolites in senile dementia-A combined trial and biochemical study. Psychol. Med. 1 : 166-171, 1971.
 
9) Strachan RW and Henderson JG : Dementia and folate dificiency. Quat.J.Med, New series 36 : 189-204, 1967.
 
10) 千葉 進, 伊藤公晴, 菊池 進・他 : 老齢者における精神機能の衰退と血中および髄液中葉酸濃度との関連性についての臨床的研究. 臨床成人病 12 : 1467-1471, 1982.
 
11) Regland B, Abrahamsson L, Blennow K, et al : Vitamin B12 in CSF : reduced CSF/serum ratio in demented men. Acta Neurol. Scand.85 : 276-281, 1992.
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P.107 掲載の参考文献
1) Shrieve DC, Denekamp J, Michinton Al : Effects of glutahione depletion by buthionine sulfoximine on radiosensitization by oxygen and misonidazole in vitro. Raiat Res 102 : 283-294, 1985
 
2) Babson JR, Abell NS, Read DJ : Protective role of the glutathione redox cycle against adriamycin-mediated toxicity in isolated hepatocytes. Biochem Pharmacol 30 : 2299-2304, 1981
 
3) Hissin PJ. Hilf R : Afluorometric method for determination of oxidized and reduced glutathione in tissues. Anal Biochem 74 : 214-226. 1976
 
4) Murry GI, Burk MD, Ewen SWB : Glutathione localization by a novel ophthalaldehyde histofluorescence method. Histochem J 18 : 434-440, 1986
 
5) Orlowski M, Karkowsky A : Glutathione metabolism and some possible functions of glutathione in the nervous system. Int Rev Neurobiol 19 : 75-121, 1976
 
6) Kosower NS, Kosower EM : The glutathione status of cells. Int Rev Cytol 54 : 109・160, 1978
 
7) Reed DJ : Regulation of reductive processes by glutathione. Biochem Pharmac 35 : 7-13, 1986,
 
8) Bozzi A, Mavelli I, Mondovi B, et al : Differential sensitivity. of tumor cells to externally generated hydrogen peroxide. Role of glutathione and related enzymes. Cancer Biochem Biophys 3 : 135-141, 1979
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9) Meredith MJ, Reed DJ : Depletion in vitro of mitochondrial glutathione in rat hepatocytes and enhancement of lipid peroxidation by adriamycin and 1,3-bis-(2-chloroethyl)-1-nitrosourea(BCNU). Biochem Pharmacol 32 : 1383-1388, 1983
PubMed
10) 松谷雅生 : 脳腫瘍の放射線治療. 癌と化学療法 14 : 3219・3226, 1987
 

Session 細胞

P.114 掲載の参考文献
1) Hashimoto K, Saito S, Takechi O : Effect of dopamine on pancreatic secretion in dog. Br J Pharmacol 43 : 739～746, 1971
 
2) Frame CM, Davidson MB, Stturdevant RAL : Effects of the octapeptide of cholecystokinin on insulin and glucagon secretion in the dog. Endocrinology 97 : 549～553, 1975
 
3) 石原敬夫 : 膵酵素の血中逸脱機序とその排せつ, 代謝. 臨床科学 23 : 587～592, 1987
 
4) Orci L, Unger RH : Functional subdivision of islets of Langerhans and Possible role of D cells.Lancet ii : 1243～1244, 1975
 
5) Fujita H. : Pancreatic endocrine system Its functional morphology. J clin Exp Med 1988 ; 144 : 307～312
 
6) MacCord JM. : Oxgen derived free radicals in post ischemic tissue injury. N Engl J Med 1985 ; 312 : 159～163
 
7) Araki H, Lefer AM : Cytoprotection actions of prostacyclin during hypoxia in the isolated perfused cat liver. Am J Physiol 238 : H176～181, 1980
 
8) Sikujara O, Monden M, Toyoshima K, et al : Cytoprotective effect of prostaglandinI2 on ischemia induced hepatic cell injury. Transplantation 36 : 238～243, 1983
 
P.122 掲載の参考文献
1) Tracy K, Beutler B, Lowry S, et al : Shock and tissue injury inducded by recombinat human cachectin. Science 234 : 470-472, 1986.
 
2) Sherry B and Cerami : Cachectin/tumor necros is factor exerts endocrine, paracrine and autocrine control of inflammatory response. J. Cell. Biol. 107 : 1269-1277, 1988.
 
3) Old L : Tumor necrosis factor. Science 230 : 630-632, 1986.
 
4) Simionescu N and Simionescu M : Endothelial Cell Biology. Plenum Publishing Corp., New York, 1988, pp.1-120.
 
5) Farrukh I, Gurtner G and Michael J : Pharmacological modification of pulmonary vascular injury : possible role of cAMP. J. Appl. Physiol. 62 : 47-54, 1987.
 
6) Minnear F, DeMichele M, Moon D, et al : Isopro-terenol reduces thrombin-induced pulmonary endothelial permeability in vitro. Am. J.Physiol. 257 : H1613-H1623, 1989.
 
7) Minnear F, Johnson A and Malik A : β-adrenagic modulation of pulmonary transvascular fluid and protein exchange. J. Appl. Physiol. 60 : 266-274, 1987.
 
8) Stelzner T, O'Brien R, Sato K, et al : Hypoxia-induced increase in pulmonary transvascular pro-tein escape in rats. J. Clin. Invest. 82 : 1840-1847, 1988.
 
9) Stelzner T, Weil J and O'Brien R : Role of cyclic adenosine monophosphate in the induction of endothelial barrier properties. J. Cell. Physiol. 139 : 157-166, 1989.
 
10) Adkins W, Barnard J, May S, et al : Compounds that increase cAMP prevent ischemia-reperfusion injury pulmonary capillary injury. J. Appl. Physiol. 72 : 492-497, 1992.
PubMed

Session 心・肺・膵

P.128 掲載の参考文献
1) Seiichi Inayama, Tetsuichi Shibata, Junichi Ohtsuki, and Shigeji Saito : A new microanalytical method for determination of hydroxyprolin in connective tissues. Keio J. Med.27 : 43-46, 1978
 
2) Masafumi Kawamura, Ryoichi Kato, Koji Kikuchi, Koichi Kobayashi, Tsuneo Ishihara, Tetsuichi Shibata and Seiichi Inayama : Assay for type III collagenolytic activity in lung cancer tissue. CIinica Chimica Acta, 203 : 225-234, 1991
 
3) Susan M. Deneke, and Barry, L. Fanburg : Normobaric oxygen toxicity of the lung. New Engl.J. Med., 303 : 76, 1980.
 
4) J.M. Clark and C. J. Lambertsen : Pulmonary oxygen toxicity : a review. Pharmacol.Rev., 23 : 23, 1971.
 
5) Alvan, L. Barach, : The effects of atmospheres rich in oxygen on normal rabbits and on rabbits with pulmonary tuberculosis. Amer. Rev. Tuberc., 13 : 293, 1926.
 
6) Gerald A. Brooksby, Robert L. Dennis, and Robert W. Staley : Effects of prolonged exposures of rats to increased oxygen pressures. Proceedings of the third international conference on hyperbaric medicine, 208, 1966
 
P.132 掲載の参考文献
1) 山口裕也, 木村寿也, 矢津 剛・他 : セルレイン誘発膵炎に関する酵素学的研究. 日消誌 84 : 1142, 1987.
 
2) Tani S, Okabayashi Y, Nakamura T et al : Effect of a new cholecystokinin receptor antagonist loxiglumide on acute pancreatitis in two experimental animal models. Pancreas 5 : 284-290, 1990.
PubMed
3) Hirano T, Manabe T, Tobe T : Effect of urinary trypsin inhibitor on pancreatic cellular and lysosomal fragility in cerulein-induced acute pancreatitis in rats, Dig. Dis. Sci.38 : 660-664, 1993.
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4) 大槻 眞, 木村 篤, 岡林克典・他 : トリプシン インヒビター投与ラットの膵外分泌機能. 現代医療 20 : 1051-1964, 1988.
 
5) Jimi A, Funakoshi A, Miyasaka K : The prophylactic effects of camostate ingestion on caerulein-induced pancreatitis in rats. J.Clin. Electorn Microscopy 22 : 5-6, 1989.
 
P.136 掲載の参考文献
1) Steer ML and Meldolesi J : The cell biology of experimental pancreatitis. N. Engl. J. Med.316 : 144-150, 1987.
PubMed
2) 平野鉄也, 真辺忠夫, 戸部隆占 : ライソゾーム酵素動態からみた肝切除ラットの膵腺房細胞の脆弱性. 日本外会誌 92 : 175-180, 1991.
 
3) Hirano T, Saluja A, Ramarao P, et al : Effects of chloroquine and methylamine on lysosomal enzyme secretion by rat pancreas. Am. J. Physiol 262 : G439-444, 1992.
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4) Irie A, Hunaki K, Bando K, et al : Activation of α-amylase in urine. Clin. Chim. Acta 51 : 241-245, 1974.
 
5) Hummel BC : Amodified spectrophotometric determination of chymotrypsin, trypsin and thrombin. Can. J. Biochem. Physiol. 37 : 1393-1399, 1959.
 
6) McDonald JK and Ellis S : On the subst-rate specificity of cathepsin B1 and B2 including a new fluorogenic substrate for cathepsin B1. Life Sci. 17 : 1269-1276, 1975.
 
7) Hirano T, Manabe T and Tobe T : Protection by gabexate mesilate(FOY) of the exocrine pancreas in rats with acute pancreatitis induced by a supramaximal dose of caerulein. J. Gastroenterol. Hepatol. 6 : 260-264, 1991.
PubMed
8) Hirano T, Manabe T, Imanishi K, et al : Protective effect of a cephalosporin, Shiomarin, plus a new potent protease inhibitor, E3123, 0n rat taurocholate-induced pancreatitis. J. Gastroenterol. Hepatol.8 : 52-59, 1993.
 
9) Greenbaum LM and Hirshkowitz A : Endogenous cathepsin activation of trypsinogen in extracts of dog Pancreas. Proc. Soc. Exp. Biol. Med.107 : 74-76, 1961.
PubMed
10) Shikimi T, Hanada M : lnhibitory effect of human urinary trypsin inhibitor (urinastatin) on lysosomal thiol proteases. Jpn. J. Pharmacol.42 : 571-574, 1986.
 

Session フリーラジカル

P.142 掲載の参考文献
1) Conte JV, Katz NM, Wallace RB, et al : Long-term Lung Preservation with the PAF antagonist BN52021. Transplantation 51 : 1152-1156, 1991.
 
2) Corcoran PC, Wang Y, Katz NM, et al : Platelet activating factor antagonist enhances lung preservation in a canine model of single lung allotransplantation. J. Thorac. Cardiovasc. Surg. 104 : 66-72, 1992.
 
3) Tagawa T, Kawahara K, Takahashi T, et al : Effects of platelet-activating factor antagonist TCV-309 on 24-h canine lung preservation. Cytoprotection and Cytobiology 10 : 129-137, 1992.
 
4) Ohakawa H, Ohishi N and Yagi K : Assay for Lipid Peroxides in Animal Tissues by Thio-barbituric Acid Reaction. Anal. Biochem 95 : 351-358, 1979.
 
5) Lowry OH, Rosebrough NJ, Farr AL, et al : Protein measurement with the Folin phenol reagent. J. Biol Chen 193 : 265-275, 1951.
 
6) Rubin BB, Smith A, Liauw &et al : Complement activation and white cell sequestration in postischemic skeletal muscle. Am. J. Physiol. 259 : H525-531, 1990.
PubMed
7) Terashita Z, Kawamura M, Takatani M, et al : Beneficial Effects of TCV-309, a Novel Potent and Selective Platelet Activating Factor Antagonist in Endotoxin and Anaphylactic Shock in Rodents. J. Pharmacol. Exp. Ther 260 : 748-755, 1992.
PubMed
8) Wahlers T, Hirt SW, Haverich A, et al : Future horizons of lung preservation by application of a platelet-activating factor antagonist compared with current clinical Euro-Collins flush perfusion versus donor core cooling. J. Thorac. Cardiovasc. Surg.103 : 200-205, 1992.
 
9) Qayumi AK, Jamieson WRE and Pooatizadeh A : Effects of Platelet-Activating Factor Antagonist CV-3988 in Preservation of Heart and Lung for Transplantion. Ann. Thorac. Surg 52 : 1026-1032, 1991,
 
P.145 掲載の参考文献
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