Cyto-protection ＆ biology Vol.12 1994年 第12回 サイトプロテクション研究会

出版社： 癌と化学療法社
著者：
発行日： 1994-12-12
分野： 臨床医学：基礎  >  臨床細胞学
ISSN： 0289-368
電子書籍版： 1994-12-12
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1994年　第12回　サイトプロテクション研究会。今回は、36題の多くの応募をいただいた。「活性酸素」については、特別講演として慶應大学医学部、末松誠先生にまとめていただいた。

目次

  • 表紙
  • 序文
  • 目次
  • 特別寄稿
  • Nitric oxide (NO) をめぐって
  • 特別講演
  • 司会
  • 臓器微小循環障害における活性酸素種のクロストーク
  • Session 胃粘膜障害
  • 座長
  • アンモニアのヒト胃癌培養細胞の細胞周期に与える影響
  • リン脂質代謝からみた急性胃粘膜病変の発生機序
  • ストレス下の血小板の役割 ―下垂体-副腎系の関与―
  • Session 胃粘膜防御機構
  • 座長
  • 自然発生胃潰瘍マウスWBB6F1-W/Wvにおける胃粘膜防御製剤テプレノンの効果
  • 急性膵炎時における各種抗潰瘍剤の胃粘膜防御機構に及ぼす影響
  • Prostaglandinの胃cytoprotection作用における胃粘液および胃粘膜細胞動態の役割
  • In vitro胃粘膜上皮細胞修復モデルにおけるEGFの効果
  • 増殖因子による培養胃粘膜細胞の分化と増殖
  • Session 腫瘍, 膵炎など
  • 座長
  • MST-16によるadriamycinの抗腫瘍効果増強と毒性軽減に関する研究
  • 胃癌に対するCDDPとSolcosery(R) の併用投与における抗癌効果
  • Caerulein誘発膵炎ラットに対する合成プロテアーゼ阻害剤(E-3123)の予防的効果の検討
  • Session 肝障害
  • 座長
  • Prostaglandin E1の肝血流に及ぼす効果 ― 特に門脈内投与の有用性について―
  • Lipiodol targeted chemotherapy誘発肝不全に対するrandomized control studyによるlipo-PGE1投与効果の検討
  • Glycineのchemical ischemiaに対する肝細胞保護作用について
  • 閉塞性黄疸肝の膜流動性と胆汁酸組成変化の意義
  • Session 虚血再灌流障害1
  • 座長
  • 虚血・再灌流性肝障害発生におけるKupffer細胞の役割
  • 局所脳虚血後のラット脳のSOD様活性の経時的変化
  • Session 虚血再灌流障害2
  • 座長
  • 血管内皮細胞障害の制御とその応用 ―新しい臓器保存液の開発に向けて―
  • UW液を用いた心保存時心筋障害の病態生理 ―イヌ摘出心による実験的検討―
  • イヌ24時間保存肺同種移植におけるlow potassium UW solutionおよびTCV-309の有用性の検討
  • Session Chemical mediator
  • 座長
  • Platelet activating factor (PAF) による顆粒球接着分子発現と抗アレルギー剤塩酸アゼラスチンの効果
  • シンポジウム「Nitric oxideをめぐって」
  • 展望
  • 胃粘膜傷害とnitric oxide(NO)
  • 血中エタノールと胃のサイトプロテクション ―NOの役割―
  • エンドトキシンショックにおけるグルタチオン代謝動態
  • 保存肝の類洞壁機能評価とnitric oxide産生動態
  • 脳虚血再灌流におけるplasma NO end productsの変動
  • 腎疾患とnitric oxide
  • 部位特異的SOD誘導体による循環制御機構の解析
  • 研究会会則
  • 役員リスト
  • 奥付
  • 会告

この書籍の参考文献

参考文献のリンクは、リンク先の都合等により正しく表示されない場合がありますので、あらかじめご了承下さい。

本参考文献は電子書籍掲載内容を元にしております。

特別寄稿

P.6 掲載の参考文献
1) Palmer RMJ, Ashtoll DS and Moncada S: Vascular endothelial cells synthesize nitric oxide from L-arginine. Nature 333: 664-666, 1988.
 
2) Ignarro LJ: Signal transduction mechanisms involving nitric oxide. Biochem. Pharmacol. 41: 485-490, 1991.
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3) Kosaka H, Harada N and Watanabe M: Detection of nitric oxide production in lipopolysaccharide-treated rats by ESR using carbon monooxide hemoglobin. Biochem. Biophys. Res. Commun. 184: 1119-1124, 1992.
 
4) Akaike T, Yoshida M, Miyamoto Y, et al: Antagonistic action of imidazolineoxyl N-oxides against endothelium-derived relaxing factor/NO through a radical reaction. Biochemistry 32: 827-832, 1993.
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5) Yoshikawa T, Murakami M, Seto O, et al: Effects of superoxide dismutase and catalase on endotoxin shock. J. Clin. Biochem. Nutr. 1: 165-170, 1986. 1: 165-170, 1986.
 
6) Hutcheson IR, Whittle BJR and Boughton-Smith NK: Role of nitric oxide in maintaining vascular integrity in endotoxin-in-duced acute intestinal damage in the rat. Br. J. pharmacol. 101: 815-820, 1990.
 
7) Boughton-Smith NK, Hutcheson IR, Deakin AM, et al: Protective effect of S-nitroso-N-acetyl-penicilamine in endotoxin-induced acute intestinal damage in the rat. Eur. J. Pharmacol. 191: 485-488, 1990.
 
8) Takahashi S: Role of nitric oxide in acute intestinal damage induced by endotoxin in rats. J. Kyoto Pref. Univ. Med. 102: 107-128, 1993. fed. 102: 107-128, 1993.
 
9) Petros A, Bennett D and Vallance P: Effect of nitric oxide synthase inhibitors on hypotension in patients with septic shock. Lancet 338: 1557-1558, 1991.
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10) Vallance P and Moncada S: Hyperdyllamic circulatioll in cirrhosis; a role for nitric oxide? Lancet 337: 776-778, 1991.
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11) Caplan MS, Hedlund E, Hill N, et al: The role of endogellous nitric oxide and platelet-activating factor in hypoxia-induced intestinal injury in rats. Gastroenterology 106: 346-352, 1994.
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12) Roediger WEW, Lawson MJ and Nance SH: Detectable colonic nitrite levels in inflammatory bowel diseases-mucosal or bacterial malfunction? Digestion 35: 199-204, 1986.
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13) Miller MJS, Sadowska-Krowicka H, Chotinaruemol S, et al: Amelioration of chrotlic ileitis by nitric oxide synthase inhibition. J. Pharmacol. Exp Therap. 264: 11-16, 1993.
 
14) Billiar TR, Curran RD, Stuehr DJ, et al: An L-arginine-dependent mechanism mediates Kupffer cell inhibition of hepatocyte protein synthesis in vitro. J. Exp. Med. 169: 1467-1472. 1989.
 
15) Oshita M, Takei Y, Kawano S, et al: Role of endothelin-1 and nitric oxide in the mechanism for ethanol. induced vasoconstriction in rat liver. J. Clin. Invest. 91: 1337-1342, 1993.
 
16) Oshita M, Sato N, Yoshihara H, et al: Ethanol-induced vasocollstriction causes focal hepatocellular injury in the isolated perfused rat liver. Hepatology 16: 1007-1013, 1992.
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17) Jaeschke H, Schini VB and Farhood A: Role of nitric oxide in the oxidant stress during ischemia/reperfusion of the liver. Life Sci. 50: 1797-1804, 1992.
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18) Linder L Kiowski W and Buhler FR: Indirect evidence for release of endothelium-derived relaxing factor in human forearm circulation in vivo;blunted response in essential hypertention. Circulation 81: 1762-1767, 1990.
 
19) Samuni A, Winkelsberg D and Pinson A: Nitroxide stable radicals protect beating cardiomyocytes against oxidative damage. J. Clin. Invest. 87: 1526-1530. 1991.
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20) 堀 正二, 北風政史, 高島成二・他: 心筋虚血におけるNO産生とその意義. 活性酸素の臨床への展望-NO(一酸化窒素)とSOD-(谷口直之 編集) , 医薬ジャーナル社, 大阪, 1994, pp. 29-35.
 
21) 工藤雅治, 渋木克栄: 脳とNO. 活性酸素・フリーラジカル 4: 513-521, 1993.
 

特別講演

P.13 掲載の参考文献
1) Palmer RMJ, Ferrige AG and Moncada S: Nitric oxide accounts for the biological activity of endothelium. derived relaxing factor. Nature 327: 524-526, 1987.
 
2) Zweifach BW, Kavalcheck S, Delano FA, Chen P: micropressure flow relationships in askeletal muscle of spontaneously hypertensive rats. Hypertension 3: 601-614, 1981.
 
3) Suematsu M, Nishino T, Schmid-Schonbein GW: Cancellation of nitric oxide-mediated microvascular flow regulation by xanthine oxidase-mediated oxidative stress in spantaneovsly hypertensive rats. Int. J Microcixc. Clin. Exp. 14: 22, 1994(abstract) .
 
4) Suzuki H, Suematsu M, Ishii H, et al: Prostaglandin EI abrogates early reductive stress and zone-specific oxidative injuny in hypoperfused rat liver. J Clin. Invest. 93: 155-164, 1994.
 
5) Stuehr DJ and Nathan CF: Nitric oxide: a macrophage product responsible for cytostasis and respiratory inhibition in tumor target cells. J Exp. Med. 169: 1543-1555, 1989.
 
6) Suematsu M, Tamatani T, Delano FA, et al: Schmid-Schenbein GW. Micro-vascular oxidative stress preceding leukocyte activation elicited by in vivo nitric oxide suppression. Am. J. Physiol. 266(35) : H2410-H2415, 1994.
 
7) Patel KD, Zimmerman GA, Prescott SM, et al: 0xygen radicals induce human endo-thelial cells to express GMP140 and bind neutrophils. J. Cell Biol. 112: 749-759, 1991.
 
8) Kanner J, Harel S and Granit L: Nitric oxide, an inhibitor of lipid peroxidation by lipoxygenase. cyclooxygenase and hemoglobin. Lipids 27: 46 49, 1992.
 

Session 胃粘膜障害

P.17 掲載の参考文献
1) Warren JR and Marshall BJ: Unidentified curved bacilli on gastric epitheliuln in active chronic gastritis. Lancet i: 1273-1275, 1983.
 
2) Graham DY: Campylobacter pylori and peptic ulcer disease. Gastroenterology 96: 612-625, 1989.
 
3) Suzuki M, Miura S, Suematsu M, et al: Helicobacter pylori-associated ammonia production enhances neutrophil-dependent gastric mucosal cell injury. Am. J physiol. 263: G715-G725, 1992.
 
4) Akagi T and Kimoto T: Human cell line (HGC-27) derived from the metastatic lymph node of gastric cancer. Acta Med. Okayama 30: 215-217, 1976.
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5) Tsujii M, Kawano S, Tsuji S, et al: Mechanism of gastric mucosal damage induced by ammonia. Gastroenterolgy 102: 1881-1888, 1992.
 
6) Brenes F, Ruiz B, Correa P, et al: Helicobacter pylori causes hyperproliferation of the gastric epithelium;pre-and post-eradication indices of proliferating cell nuclear antigen. Am. J. Gastroenterol. 88: 1870-1875, 1993.
PubMed
7) Tsujii M, Kawano S, Tsuji S, et al: Cell kinetics of mucosal atrophy in rat stomach induced by long-term administration of ammonia. Gastroenterolog. 104: 796-801, 1993.
 
8) Kohli Y, Kato T, Yamazaki Y, et al: Effects of 0.02%or 0.11% NH3 solution on gastric mucosa in rats. J. Kyoto Pref. Univ, Med. 99: 1189-1197, 1990.
 
9) Parsonnet J, Friedman GD, Vandersteen DP, et al: Helicobacter pylori infection and the risk of gastric carcinoma. N. Engl. J. Med. 325: 1127-1131, 1991.
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P.22 掲載の参考文献
1) Nagamachi Y: New method of obtaining cinchophen ulcer in dogs. Am. J. Dig. Dis. 22: 761-768, 1977.
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2) 小板橋宏: シンコフェンによるストレスのラット赤血球表面形態におよぼす影響. 北関東医学 42: 577-595, 1992.
 
3) 長町幸雄: 胃粘膜局所の物理的変化に対するセトラキセートの影響-実験潰瘍発生成因の面から-. 薬理と治療 11: 5181-5194, 1983.
 
4) Weltzien HU: Cytotoxic and membrane perturbing Properties of lysophosphatidylcholine. Biochim. Biophys. Acta 559: 259-273, 1979.
 
5) John Maksem MD, Neil Jacobson MD, Neiderhiser Rhd, et al: Lysophosphatidyl-choline-induced gastric injury and ulceratioll in the guinea pig. Am. J. Physiol. 115: 288-295, 1984.
 
6) Hirohara J, Sugatani J, Saito K, et al: Properties and localization of phospholipase A2 activity in rat stomach. Biochim. Biophys ACta 919: 231-238, 1987.
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7) Zhang Y and Dennis EA: Purification and characterization of a lysophospholipase from a macrophage-like cell line P388D1. J. Biol. Chem. 263: 9965-9972, 1988.
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8) Gross RW and Sobel BE: Rabbit myocardial cytosolic lysophospholipase. Purification, characterization, and competitive inhibition by L-palmitoyl carnitine. J. Biol. Chem. 258: 5221-5226, 1983.
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9) Nagamachi Y: Significance of gastric mucosal pepsinogen and plasma corticosteroid levels in the course of cinchophen ulceration. Gastroenterol. Jpn. 12: 14-20, 1977.
 
10) Sugimoto H and Yamashita S: Purification, characterization, and inhibition by phosphatidic acid of lysophospholipase transacylase from rat liver. J Biol. Chem. 269: 6252-6258, 1994
 
P.27 掲載の参考文献
1) 澤井洋子, 今井重之, 荻原茂樹・他: 実験的ストレス潰瘍発生・進展過程における血小板, 凝固・線溶系の変動. 日血会誌 50: 470, 1987.
 
2) Paret RS, Kumashiro R, Kodama Y, et al: The effect of dipyridamole on experimentally induced stress ulcer. Am. Surg. 48: 594-596, 1982.
PubMed
3) Kumashiro R, Montgomery O, Langman A, et al: The preventive effect of low dose aspirin in the development of stress ulceration in rats. Am. Surg. 49: 423-427, 1983.
PubMed
4) Kumashiro R, Piotrowski J, Kholoussy AM, et al: Antiplatelet aggregator inhibit development of stress ulcers in sprague-dawley rats. Eur. Surg. Res. 17: 44-52, 1985.
PubMed
5) Hirsh J and Brain EA: Hemostasis and Thrombosis. Churchill Livingstone, New York, 1983.
 
6) Maffrand JP, Bernat A, Delebassee D, et al: ADP plays a key role in thrombogenesis in rats. Thromb. J: Haemost. 59: 225-230, 1988.
 
7) 松田 保: 血栓形成と動脈硬化. 動脈硬化症研究の進歩(動脈硬化セミナー), Vol. 3, 医歯薬出版, 東京, 1982, pp. 3-50.
 

Session 胃粘膜防御機構

P.30 掲載の参考文献
1) Shimada M, Kitamura Y, Yokoyama M, et al: Spontaneous stomach ulcer in genetically mast-cell depleted W/WV mice. Nature 283: 662-664, 1980.
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2) 春日井務, 森本将弘, 北村幸彦: マスト細胞毛欠損動物 c-kit レセプターとそのリガンドの異常. 細胞工学 10: 587-591, 1991.
 
3) Nocka K, Tan JC, Chiu E, et al: Molecular bases of dominant negative and loss of function mutations at the murine c-kit/white spotting locus;W37, WV, W41, and W. EMBO J 19: 1805-1813, 1990.
 
4) Yokoyama M, Tatsuta M, Baba M, et al: Bile reflux;A possible cause of stomach ulcer in nontreated mutant mice of W/WV genotype. Gastoenterology 82: 857-863, 1982.
 
5) Maeda H, Yamagata A, Nishikawa S, et al: Requirenlellt of c-kit for developnlent of intestinal pacemaker system. Development 116: 369-375, 1992.
PubMed
6) Terano A, Shiga J, Hiraishi H, et al: Protective action of tetraprenylacetone against ethanol-induced damage in rat gastricmucosa. Digestion 35: 182-188, 1986.
 
7) Bilski J, Sarosiek J, Murty V L N, et al: Enhancement of the lipid content and physical properties of gastric mucus by geranylgeranylacetone. Biochem. Pharmacol. 36: 4059-4065, 1987.
 
8) Arakawa T, Yamada H, Nakamura A, et al: Gastric cytoprotection by tetraprenylacetone in human subjects. Digestion 39: 111-117, 1988.
PubMed
P.36 掲載の参考文献
1) 友永健治, 長畑洋司, 斎藤洋一: 膵疾患と胃の相関. 消化器血流の研究 8(消化器血流研究会編), 第1版, メディカルトリビューン, 東京, 1992, pp. 69-73.
 
2) 藤原元始, 森 襄: 実験的stress胃潰瘍とAmine. 最新医学 25: 2058-2067, 1970.
 
3) 石原和彦, 森下 薫, 小原 進・他: 胃粘液含量測定法としての胃粘膜ヘキソサミン定量の妥当性についての検討. 日消誌 86: 111, 1989.
 
4) 水本龍二, 伊佐地秀司, 佐藤芳邦: 急性膵炎とmultiple organ failure. 胆と膵 5: 309-316, 1984.
 
5) 香川修司, 裏川公章, 斎藤洋一: 急性膵炎時の胃病変発生機序についての実験的研究. 神大医紀 47: 169-177, 1986.
 
6) 阿部道夫: 胃膵相関の臨床. 医学のあゆみ 105: 917-923, 1978.
 
7) 岡田正典, 塚本純久, 中澤三郎: 急性膵炎に伴なう急性胃粘膜障害に関する実験的研究. 日消誌 81: 2568-2576, 1984.
 
8) 八田 敏: ストレス潰瘍発生時の自律神経に関する実験的研究-胃壁血流量および胃運量の測定より-. 日外会誌 82: 1212-1223, 1981.
 
9) 大川博之, 小原 進, 石原和彦・他: 酸分泌刺激剤及び塩酸のラット胃粘膜粘液糖タンパク質に及ぼす影響. 日消誌 86: 1369-1375, 1988.
 
10) 村上 学, 若林庸夫: テプレノンの開発. Pharma. Medica, 4: 91-99, 1986.
 
P.40 掲載の参考文献
1) Miller TA: Protective effects of prostaglandins against gastric mucosal damage, current knowledge and proposed mechanisms. Am. J. Physiol. 245: G601-G625, 1983.
PubMed
2) Ota H, Katsuyama T, Ishii K, et al: Adual staining method for identifying mucins of different gastric epithelial mucous cells. Histochem. J. 23: 22-28, 1991.
 
3) Hattori T: On cell proliferation and differentiation of the fundic mucosa of the golden hamster. Cell Tiss. Res. 148: 213-226, 1974.
 
4) 浅田修二: 画像処理装置(VIP)による胃粘液量の検討. 大阪医大誌 46: 62-76, 1987.
 
5) Bolton JP, Palmer D and Cohen MM: Stimulation of mucus and nonparietal cell secretion by the E2 prostaglandins. Am. J. Dig. Dis. 23: 359-364, 1978.
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6) Johansson C and Kollberg B: Stimulation by intragastrically administered E2 prostaglandins of human gastric mucus output. Eur. J. Clin. Invest. 9: 229-232, 1979.
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7) 梅垣英次, 滝内比呂也, 浅田修二・他: 粘液溶解剤のエタノール胃病変および胃粘液に及ぼす影響. Ulcer Research 19: 80-84, 1992.
 
8) 滝内比呂也: 胃粘膜保護作用における粘液の役割に関する実験的研究. 大阪医大誌 52: 45-52, 1993.
 
9) Robert A, Nezamis JE, Lancaster C, et al: Cytoprotection by prostaglandins in rats, prevention of gastric necrosis produced by alchol, HCl, NaOH, hypertonic NaCl, and thermal injury. Gastroenterology 77: 433-443, 1979.
 
10) Lacy ER and Ito S: Microscopic analysis of ethanol damage to rat gastric mucosa after treatment with a prosta glandin. Gastroenterology 83: 619-625, 1982.
 
P.42 掲載の参考文献
1) Cohen S : Isolation of a mouse submaxillary gland protein accelerating incisor eruption and eyelid opening in the new born animal J. Biol. Chem. 237:1555-1562, 1962.
PubMed
2) Konturek SJ, Radeci T, Brzozowskl T, et al: Gastric cytoprotection by epidemal growth factor. Role of endogenous prosta glandins and DNA synthesis. Gastroenterology 81: 438 443, 1981
 
3) Koturek SJ, Dembms ki A, Warzecha Z, et al: Role of epidermal growth factor in healing of chronic gastroduodenal ulcers in rats. Gastroenterology 94: 1300-1307, 1988
 
4) Konturek SJ, Cleszkowski M, Jaworek J, et al: Effects of epidermal growth factor on gastrointestinal secretion. Am. J. Physiol. 246: G580-586, 1984.
 
5) Watanabe S, Wang X, Hirose M, et al: Effect of myosin light chain kinase inhibitor wortmannin on the wound repair of cultured gastric mucosal cells. Biochem. Biophys. Res. Commun. 199: 799-806, 1994.
PubMed
6) Watanabe S, Hirose M, Wallg X, et al: Hepatocyte growth factor accelerates the wound repair of cultured gastric mucosal cells. Biochem. Biophys. Res. 199: 1453-1460, 1994.
 
P.48 掲載の参考文献
1) Karam SM and Lebond CP: Dynamics of epithelial cells in the corpus of the mouse stomach. 1. Identification of proliferative cell types and pinpointing of the stem cell. Anat. Rec. 236: 259-279, 1993.
 
2) Karam SM and Lebond CP: Dynamics of epithelial cells in the corpus of the mouse stomach. 2. Outward migration of pit cells. Anat. Rec. 236: 280-296, 1993.
 
3) Karam SM and Lebond CP: Dynamics of epithelial cells in the corpus of the mouse stomach. 3. Inward migration of neck cells followed by progressive transformation into zymogenetic cells. Anat. Rev. 236: 297 313, 1993.
 
4) Karam SM and Lebond CP: Dynamics of epithelial cells in the corpus of the mouse stomach. 4. Bidirectional migration of parietal cells ending in their gradual degeneration and loss. Anat. Rec. 236: 314-332, 1993.
 
5) Karam SM and Lebond CP: Dynamics of epithelial cells in the corpus of the mouse stomach. 5. Behavior entero-endocrine and caveolated cells;general conclusions on cell kinetics in the oxyntic epithelium. Anat. Rec. 236: 333-340, 1993.
 
6) Hattori K, Sakano Y, Fujita S, et al: Tritiated thymidine autoradiographic study on cellular migration in the gastric glands of the golden hamster. Cell Tissue Res. 172: 171-184, 1976.
 
7) Terano A, Ivey KJ, Stachura J, et al: Cell culture of rat gastric fundic mucosa. Gastroenterology, 83: 1280-1291, 1982.
PubMed
8) Nakamura K, Rokutan K, Marui N, et al: Induction of heat shock proteins and their implication in protection against ethanol induced damage in cultured guinea pig gastric mucosal cells. Gastroenterology 101: 161-166, 1991.
PubMed
9) Katsuyama T, Ono K, Nakayama J, et al: Recent advances in mucosubstance histochemistry. Gastric mucus and mucus secreting cells(edited by Kawai K) , Excerpta Medica, Tokyo, 1985, pp. 3-18.
 
10) Sarosiek J, Bilski J, Murty VLN, et al: Role of pshycochemical characteristics of oral and gastric mucosal coat., Biochem. Biol Res. Commun. 152: 1421-1427, 1988.
 
P.52 掲載の参考文献
1) Narita T, Koide Y, Yaguchi S, et al: An-titumor activities and schedule dependence of orally administered MST-16, a novel derivative of bis (2,6. dioxopiperazine) . Carcer Chemother, Pharmacol. 28: 235-240, 1991.
 
2) 正岡 徹, 陰山 克, 巽 典之・他: MST-16 (Sobuzoxane) の悪性リンパ腫に対する後期臨床第II相試験. 癌と化学療法 19: 339-347, 1992.
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4) Chou TC and Talalay P: Applications of themedian-effect principle for the assessment of low-dose risk of carcinogens and for the quantitation of synergism and antagonism of chemotherapeutic agents. Bristol Meyers Cancer Symposia 8: 37-64, 1987.
 
5) Wadler S, Green DM and Basch R: Lethal and sublethal effects of the combinatin of doxorubicin and the bisdioxopiperazine, (+) -1, 2, -bis (3-5-dioxopiperazinyl-1-yl) propane(ICRF-187) on murine sarcoma S180 in vivo. Biochem. Pharmacol. 36: 1495-1501, 1987.
 
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4) 岩佐 博, 三村一夫, 大崎裕子・他: マウス Meth-A 腫瘍に対するソルコセリルおよび FT-207 の併用効果について. 癌と化学療法 10: 254-260, 1983.
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5) 宇田川郁夫, 宮崎 勝, 越川尚男・他: 部分肝阻血時の肝ライソゾーム膜脆弱性より見た肝細胞障害およびプロスタグランジンE1誘導体の影響. 日外会誌 93: 288-294, 1992.
 
6) Fanton JC and Kinnes DA: Prostaglandin E1 and prostaglandin I2 modulation of superoxide production by human neutrophils. Biophys. Res. Commun. 113: 506-512, 1983.
 
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2) 石井良知: ケノデオキシコール酸の培養ラット肝細胞に及ぼす影響と, Prostaglandin E1の細胞保護作用について. 日消病会誌 82: 108-117, 1985.
 
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Session 虚血再灌流障害2

P.94 掲載の参考文献
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4) Seibert A, Thompson W, Taylor A, et al: Reversal of increased microvascular permeability associated with ischemia-reperfusion: role of cAMP. Appl. Physiol. 72: 389-395, 1992.
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6) Koga S, Ogawa S, Kuwabara K, et al: Synthesis and release of interleukin-1 by reoxygenated human mononuclear phagocytes. J Clin. Invest. 90: 1007 1015, 1992.
 
7) Suttorp N, Weber U, Welsch T, et al: Role of phosphodiesterase in the regulation of endothelial permeability in vitro. J. Clin. Invest. 91: 1421 1428, 1993.
 
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9) Koga S, Han D, Kline R P, et al: Electrical evaluation of myocardial viability following prolonged storage of explanted hearts. Circulation 86(4) : I-770, (Abstr) , 1992.
 
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11) Oz M, Pinsky D, Koga S, et al: Enhanced donor heart preservation with a novel cAMP based solution Circulation 86(4) : I-840, (Abstr) , 1992.
 
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4) Ledingham S, Katayama O, Lachno D, et al: Prolonged cardiac preservation;Evaluation of the University of Wisconsin preservation solution by comparison with the St. Thomas' Hospital cardioplegic xolutions in the rat. Circulation 82 (Suppl. IV) : IV 351-358, 1990.
 
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1) Kobayashi M: A 24 hour lung storage using low potassium UW solution. Acta Med. Nagasalei Ensia. 37: 222-228, 1992.
 
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10) Tagawa T, Kawahara K, Takahashi T, et al: Effect of platelet-activating factor antagonist TCV-309 on 24 hr canine lung preservation. CYTOPROTECTION and CYTOBIOLOGY 10: 129-137, 1992.
 

Session Chemical mediator

P.108 掲載の参考文献
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4) 片山 敏, 角田 創, 佐久間義範・他: Azelastineのロイコトリエン産生・遊離抑制作用およびロイコトリエン拮抗作用. Prog. Med. 6: 1173-1178, 1986.
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シンポジウム「Nitric oxideをめぐって」

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