狭心症とβ遮断薬 臨床薬理と臨床応用

出版社： 臨床医薬研究協会
著者：
発行日： 1989-03-10
分野： 臨床医学：内科  >  心臓
電子書籍版： 1989-03-10
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本書は、狭心症の病態から治療までを、実践に即して記述したものである。薬物治療においては、特にβ遮断薬に重点をおいた。(序文より）

目次

  • 表紙
  • 序
  • 執筆者
  • 目次
  • I. 狭心症の基礎知識―定義,病態生理,分類,診断―
  • 1. 狭心症の定義
  • 2. 病態生理
  • 3. 狭心症の分類
  • 4. 狭心症の診断
  • 付. Silent myocardial ischemia
  • II. 運動負荷心電図による狭心症の診断
  • 1. 心筋酸素需要および供給
  • 2. 心筋虚血の誘発法
  • 3. 多段階運動負荷試験の実施法
  • 4. 冠動脈疾患の診断
  • III. 狭心症治療の概要
  • 1. はじめに
  • 2. 内科的治療
  • 3. 冠動脈形成術(PTCA)
  • 4. 外科的治療
  • IV. 狭心症治療におけるβ遮断薬
  • 1. β遮断薬の種類と特徴
  • 2. β遮断薬の作用機序
  • 3. 狭心症に対するβ遮断薬の選択
  • 4. β遮断薬の抗狭心症作用の評価
  • 5. β遮断薬の適切な使い方
  • 6. β遮断薬の副作用,使用上の注意
  • V. 運動負荷心電図によるβ遮断薬の抗狭心症効果の判定
  • VI. β遮断薬の狭心症への使用例
  • 症例1 心筋梗塞後狭心症にカルシウム拮抗薬とβ遮断薬(atenolol)を併用し効果を得た例
  • 症例2 狭心症発作から呼吸困難を起こした時点でpropranolol静注が奏効した例
  • 症例3 β遮断薬と他剤との併用例
  • 症例4 β遮断薬と外科手術,PTCAとの併用例
  • 症例5 β遮断薬が有効であった陳旧性下壁心筋梗塞を伴う安定労作狭心症
  • 症例6 カルシウム拮抗薬,ISDN,β遮断薬の併用が有効であった労作狭心症
  • 症例7 β遮断薬の追加処方により悪化した安定労作狭心症
  • 奥付

この書籍の参考文献

参考文献のリンクは、リンク先の都合等により正しく表示されない場合がありますので、あらかじめご了承下さい。

本参考文献は電子書籍掲載内容を元にしております。

I. 狭心症の基礎知識―定義,病態生理,分類,診断―

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II. 運動負荷心電図による狭心症の診断

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24) Elamin, M. S., et al. :Accurate detection of coronary heart disease by new exercise test. Br. Heart. J., 48:311, 1982.
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25) Okin, P. M., et al. :Improved accuracy of the exercise electrocardiogram:identification of three-vessel coronary disease in stable angina pectoris by analysis of peak rate-related changes in ST-segment. Am. J. Cardiol., 55:271, 1985.
 
26) Quyyumi, A. A, et al. :Inability of the ST-segment/heart rate slope to predict accurately the severity of coronary artery disease. Br. Heart. J., 51:395, 1984.
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27) Balcon, R., et al. :Correlation of heart rate/ST-slope and coronary angiographic findings. Br. Heart. J., 52:304, 1984.
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28) Detrano, R., et al. :Exercise electrocardiographic variables:A clinical appraisal. J. Am. Coll. Cardiol., 8:836, 1986.
 
29) 渡辺信, 他:心拍数補正ST下降値による冠動脈疾患重症度評価. 第5回日本心電図学会学術集会抄録集, p.569, 1988.
 
30) Bononis, P. E., et al. :Evaluation of R wave amplitude changes versus ST-segment depression in stress testing. Circulation, 57:904, 1978.
 
31) Baron, D. W., et al. :R-wave amplitude during exercise. Relation to left ventricular function and coronary disease. Br. Heart. J., 44:512, 1980.
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32) Berman, J. A., et al. :Improving diagnostic accuracy of the exercise test by combining R-wave changes with duration of ST-segment depression in a simplified index. Am. Heart. J., 105:60, 1983.
 
33) Greenberg, P. S., et al. :Predictive accuracy of Q-X/Q-T ratio, Q-Tc interval, ST-depression and R-wave amplitude during stress testing. Am. J. Cardiol., 44:18, 1979.
 
34) De Caprio, L., et al. :Influence of heart rate on exercise-induced R-wave amplitude changes in coronary patients and normal subjects. Am. Heart. J., 107:61, 1984.
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35) Yiannikas, J., et al. :Analysis of exercise-induced changes in R-wave amplitude in asymptomatic men with electrocrdiographic ST-T changes atrest. Am. J. Cardiol., 47:238, 1981.
 
36) Hopkirk, J. A. C., et al. :Limitation of exercise-induced R wave amplitude changes in detecting coronary artery disease in asymptomatic men. J. Am. Coll. Cardiol., 3:821, 1984.
 
37) Fox, K., et al. :Inability of exercise-induced R wave changes to predict coronary artery disease. Am. J. Cardiol., 49:674, 1982.
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38) Deanfield, J. E., et al. :Factors influencing R wave amplitude in patients with ischaemic heart disease. Br. Heart. J., 49:8, 1983.
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39) Myers, J., et al. :Spatial R wave amplitude changes during exercise:relation with left ventricular ischemia and function. J. Am. Coll. Cardiol. 6:603, 1985.
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40) Hakki, A. H., et al. :R-wave amplitude:a new determination of failure of patients with coronary heart disease to manifest ST-segment depression during exercise. J. Am. Coll. Cardiol., 3:1155, 1984.
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41) Hollenberg, M., et al. :Influence of R-wave amplitude on exercise-induced ST depression；need for a "gain factor" correction when interpreting stress electrocardiograms. Am. J. Cardiol., 56:13, 1985.
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44) Furuse, T., et al. :Usefulness of Q-wave response to exercise as a predictor of coronary artery disease. Am. J. Cardiol., 59:57, 1987.
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45) Gerson, M. C., et al. :Exercise-induced U-wave inversion as a marker of stenosis of the left anterior descending coronary artery. Circulation, 60:1014, 1979.
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46) 都築雅人, 他:労作狭心症における運動誘発U波陰転の臨床的意義:冠動脈造影所見との対比. 心臓, 15:186, 1983.
 
47) Glazier, J. J., et al. :Increase in S-wave amplitude during ischemic ST-segment depression in stable angina pectoris. Am. J. Cardiol., 59:1295, 1987.
 
48) Yokota, M., et al. :Exercise P-vector magnitude changes in angina pectoris:Frank-vectorcardiographic and hemodynamic correlations. J. Electrocardiol., 19:115, 1986.
 
49) Robertson, D., et al:The localization of coronary artery stenosis by 12 lead ECG response to graded exercise test:support for intercoronary steal. Am. Heart. J., 91:437, 1976.
 
50) Fucks, R. M., et al. :Electrocardiographic localization of coronary artery narrowings:studies during myocardial ischemia and infarction in patients with one-vessel disease. Circulation, 66:1168, 1982.
 
51) Dunn, R. F., et al. :Localization of coronary artery disease with exercise electrocardiography:correlation with thallium-201 myocardial perfusion scanning. Am. J. Cardiol., 48:837, 1981.
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52) 斎藤二三夫, 他:多単極胸部誘導運動試験による冠動脈病変部位の推定-R波補正最大ST下降部位の検討-. 第51回日本循環器病学会総会抄録集, p.366, 1987.
 
53) Chaitman, B. R., et al. :ST-segment elevation and coronary spasm in response to exercise. Am. J. Cardiol., 47:1350, 1981.
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54) Yasue, H., et al. :Circadian variation of exercise capacity in patients with Prinzmetal’s variant angina:Role of exercise-induced coronary arterial spasm. Circulation, 59:938, 1979.
 
55) Specchia, G., et al. :Coronary arterial spasm as a cause of exercise induced ST-segment elevation in patients with variant angina. Circulation, 59:948, 1979.
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56) Boden, W. E., et al. :Exercise-induced coronary spasm with ST-segment depression and normal coronary arteriography. Am. J. Cardiol., 48:193, 1981.
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57) Longhurst, J., et al. :Exercise-induced ST elevation in patients without myocardial infarction. Circulation, 60:616, 1979.
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60) Rizi, H. R., et al. :Walk-through angina phenomenon demonstrated by graded exercise radionuclide ventriculography. Possible coronary spasm mechanism. Am. Heart J., 103:292, 1982.
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64) Detry, J. M. R., et al. :Maximal exercise testing in patients with spontaneous angina pectoris associated with transient ST segment elevation. Risks and electrocardiographic findings. Br. Heart. J., 37:897, 1975.
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65) Gensini, G. G., et al. :Arterio-graphic demonstration of coronary artery spasm and its release after the use of a vasodilator in a case of angina pectoris and in the experimental animal. Angiology, 13:550, 1962.
 
66) Oliva, P. B., et al. :Coronary artery spasm in Prinzmetal angina:documentation by coronary arteriography. N. Engl. J. Med., 288:745, 1973.
 

III. 狭心症治療の概要

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17) 秋山英明, 半田俊之介, 藤井効ほか:冠動脈疾患における側副血行の役割. 心臓, 16:259, 1984
 
18) 半田俊之介:心疾患のリハビリテーション；標準リハビリテーション医学, 上田敏ほか編. 医学書院, 308pp, 1986
 
19) Murrell, W. :Nitroglycerin as a remedy for angina pectoris. Lancet, 1:80, 113, 225, 284, 642-646, 1879
 
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IV. 狭心症治療におけるβ遮断薬

P.129 掲載の参考文献
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8) 田村康二, 他:塩酸ブプラノロール (ルーサー) の狭心症に対する治療効果について. 診療と新薬15:1737, 1978.
 
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14) 吉利和, 金沢知博, 他:Arotinolol (S-596) の狭心症に対する臨床効果. 二重盲検法によるPropranololとの比較. Clin. Eval., 11:591, 1983.
 
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V. 運動負荷心電図によるβ遮断薬の抗狭心症効果の判定

P.137 掲載の参考文献
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VI. β遮断薬の狭心症への使用例

P.144 掲載の参考文献
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2) Gold, H. K., Leinbach, R. C., Maroko, P. R. :Propranolol-induced reduction of sign of ischemic injury during acute myocardial infarction. Am. J. Cardiol., 38:689, 1976.
 
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4) Fishl, S. J., Herman, M. V., Gorlin, R. :The intermediate coronary syndrome. New Engl. J. Med., 288:1193, 1973.
 

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