気道過敏症の臨床

出版社： 永井書店
著者：
発行日： 1987-11-01
分野： 臨床医学：内科  >  呼吸器一般
電子書籍版： 1987-11-01
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目次

  • 表紙
  • 序
  • 目次
  • I. 気道過敏性の臨床
  • 第1章 気道の過敏性と肺疾患
  • 1. 喘息発作時の生理学的・形態学的変化
  • 1) 気道開大のホメオスタージス
  • 2) 喘息発作時の機能障害
  • 3) 喘息発作時の気道の形態学的変化
  • 文献
  • 2. 肺疾患における気道過敏性
  • 1) 気管支喘息
  • (1) 気道過敏性の気管支喘息に占める位置
  • (2) アレルギー反応と気道過敏性の相関関係
  • (3) 過刺激性と過反応性
  • (4) 過刺激による気道攣縮
  • (5) 過反応性を利用した喘息の臨床診断
  • (6) 喘息症状と気道過敏性
  • (7) 初期気道抵抗値と気道過敏性 : 臨床成績
  • (8) 初期気道抵抗値と気道過敏性 : 実験成績
  • 2) その他の肺疾患
  • (1) 慢性閉塞性肺疾患
  • (2) 拘束性肺疾患
  • 文献
  • 3. 喘息患者の臨床症状と呼吸機能
  • 1) 定義
  • 2) 経過による閉塞性障害の差
  • 3) 呼吸機能
  • 4) 肺気量の変化
  • 5) 肺弾性圧の変化
  • 6) 呼吸中枢の反応
  • 7) 喘息患者の気道, 肺胞系
  • 文献
  • 4. 喘息発作の誘因
  • 1) 抗原吸入
  • 2) 感染 (感冒)
  • 3) 運動
  • 4) 冷気
  • 5) 大気汚染物質
  • 6) 精神的影響
  • 7) 日差変動
  • 8) 季節変動
  • 9) タバコ
  • 10) アルコール
  • 文献
  • 第2章 気道過敏性の臨床的把握
  • 1. 気道攣縮の検出方法
  • 1) スパイログラフィー
  • 2) Specific conductance (SGaw)
  • 3) 呼吸抵抗 (RrsまたはRT)
  • 4) フローボリウム曲線 (V-V曲線)
  • 5) 動肺コンプライアンス (Cdyn)
  • 6) クロージングボリウム
  • 文献
  • 2. 気道過敏性の測定方法
  • 1) 定量エロゾル発生装置法
  • 2) 安静換気法
  • 3) 気道過敏性の標準化案
  • 4) アストグラフ法
  • 5) Dosimeter法とアストグラフ法との比較
  • 文献
  • 3. 気道過敏性の局在性
  • 1) 中枢及び末梢性気道過敏性
  • (1) FEV1.0, SGaw, RL及びCstによる分析
  • (2) ヘリウムフローボリウム (V-V曲線による分析)
  • (3) 死腔と肺抵抗による分析
  • (4) HeとSF6吸入時の肺抵抗による分析
  • (5) その他の方法
  • 2) 喉頭部の気道過敏性
  • (1) 直接法
  • (2) Acoustic impedance法
  • (3) 声帯断面積測定法
  • (4) 低周波音波法
  • 文献
  • 4. 吸入粒子と気道過敏性
  • 1) 吸入粒子の気道内沈着分布
  • (1) ラジオアイソトープ法
  • (2) 中枢と末梢気道抵抗による測定
  • 文献
  • 5. 抗原吸入誘発試験
  • 1) 従来の抗原吸入誘発試験
  • 2) 安静換気による抗原吸入誘発試験 - アストグラフ
  • (1) アストグラフによる段階的希釈抗原吸入誘発試験
  • (2) 家塵抗原1回吸入誘発試験
  • 文献
  • 6. 運動性喘息
  • 1) 臨床症状
  • 2) メカニズム
  • (1) 冷気吸入による刺激受容体刺激
  • (2) 化学伝達物質遊離説
  • 3) 測定法
  • 4) EIAと気道過敏性の関係
  • 文献
  • 7. 気道攣縮方法と気道過敏性
  • 1) ヒスタミンとメサコリン吸入との比較
  • 2) その他の非特異的気道刺激物との比較
  • 文献
  • 8. 遅発型喘息
  • 第3章 気道過敏性の発症因子
  • 1. 自律神経
  • 1) β-受容体遮断説
  • (1) 気道の閉塞
  • (2) 薬理学的異常
  • (3) 免疫学的異常
  • (4) 気道組織の1次的関与
  • (5) 感染
  • (6) 好酸球増多
  • (7) アドレナリン反応性低下
  • (8) 非持異的な多くの誘発因子との関係
  • 2) β-受容体遮断説以後
  • 3) α-受容体緊張説
  • 4) 副交感神経緊張説
  • (1) irritant receptor説
  • (2) Organ vagotonia説
  • 5) 喘息患者の皮膚の自律神経機能
  • 文献
  • 2. アレルギー
  • 1) 米杉喘息
  • (1) 米杉オガクズからの抗原成分の抽出
  • (2) 米杉による感作とアレルギー症状
  • 文献
  • 3. 化学的伝達物質
  • 1) ヒスタミン
  • 2) Slow reacting substance of anaphylaxy
  • 3) プロスタグランジン
  • 文献
  • 4. 感染
  • 文献
  • 5. 気道粘液輸送能の過敏性
  • 1) 気道分泌腺
  • (1) 肺疾患と気道分泌液
  • (2) 気道分泌液を採取する方法
  • (3) 気道分泌液のコントロール系
  • 2) 粘液線毛輸送能
  • (1) 疾患肺における線毛運動
  • (2) 粘液線毛運動測定法
  • (3) 粘液線毛運動に影響する諸因子
  • (4) 大気汚染物質と線毛運動
  • 文献
  • II. 気道過敏性の動物モデル
  • 第1章 気道過敏性の動物モデル
  • 1. アレルギー反応
  • 1) 動物モデルとしての条件
  • 2) 即時型アレルギーの動物モデル
  • 3) 実験動物の呼吸機能
  • 4) 気道過敏性の動物モデル
  • 文献
  • 2. 動物の感作モデル
  • 1) ヒトIgEの被動感作
  • 2) サルの皮膚感作モデル
  • 3) サルの全身感作モデル
  • 4) サルの能動感作
  • 5) 抗ヒトIgE抗体チャレンジと気管支腔内肥満細胞
  • 文献
  • 3. サルの気道のリセプター
  • 1) サルの気道の自律神経
  • (1) サルの気道に対するイソプレナリン, アトロピン, フェントラミンの効果
  • (2) サル気道の収縮のメカニズム
  • 2) サル気道のヒスタミンリセプター
  • 3) サルにおけるβ-adrenergic blockadeモデル
  • 文献
  • 4. サルの気道の反応性と感染
  • 1) 百日咳菌感作
  • 2) サルのインフルエンザウイルス接種
  • 文献
  • 5. 遺伝的素因
  • 1) 気道過敏性の分布
  • 2) 気道過敏性かくとくモデル
  • 文献
  • 6. 遅発型喘息 - 動物モデル
  • 1) IgE抗体のみを有する動物
  • 2) 自然感作動物を用いたモデル
  • 3) 能動感作動物モデル
  • 4) 薬物を用いた動物モデル
  • 文献
  • 第2章 気道の受容体と神経支配による気道過敏性へ及ぼす影響
  • 1. 受容体
  • 1) 機械的受容体
  • (1) 刺激受容体と咳受容体
  • (2) 伸展受容体
  • (3) C-神経線維受容体
  • 2) 化学受容体
  • 3) 薬物に対する受容体
  • (1) ムスカリン受容体
  • (2) β2受容体
  • (3) α受容体
  • (4) ヒスタミン受容体
  • 文献
  • 2. 自律神経支配
  • 1) 副交感神経
  • 2) 交感神経
  • (1) β2作用
  • (2) α作用
  • (3) 非アドレナリン性抑制神経
  • 4) 迷走神経と薬物との相互作用
  • 5) 交感神経と薬物との相互作用
  • 文献
  • 第3章 気道平滑筋攣縮の生理学的側面
  • 1. 平滑筋攣縮のメカニズム
  • 文献
  • 2. 冠拡張薬と気道過敏性
  • 1) カルシウム・ブロッカー
  • 2) ニトロール製剤
  • 文献
  • 3. 気道平滑筋の生理学的役割
  • 文献
  • 4. 気道過敏性の物理モデル
  • 索引
  • 奥付

この書籍の参考文献

参考文献のリンクは、リンク先の都合等により正しく表示されない場合がありますので、あらかじめご了承下さい。

本参考文献は電子書籍掲載内容を元にしております。

I. 気道過敏性の臨床

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II. 気道過敏性の動物モデル

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