健康食品と薬の相互作用

出版社： 永井書店
著者：
発行日： 2011-10-10
分野： 薬学  >  薬学一般
ISBN： 9784815918903
電子書籍版： 2011-10-10 （第1版）
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商品紹介

健康食品の成分で，処方薬と相互作用をきたす可能性のあるものに注目。健康食品と薬の相互作用に対する理解と薬の適正使用を実践するための必携書。

目次

  • 表紙
  • はじめに
  • 目次
  • 宣伝されている効き目別一覧
  • 1. アスコルビン酸 ( Ascorbic acid ) ( ビタミン C )
  • 用語解説1. 肝代謝型と腎排泄型
  • 2. アフリカン・ワイルド・ポテト ( African wild potato )
  • 用語解説2. P 糖蛋白
  • 3. アミグダリン ( Amygdalin )
  • 4. アメリカ人参 ( American ginseng )
  • 用語解説3. INR
  • Column 1. 時間治療
  • 5. アルコール ( Alcohol )
  • 6. α - リポ酸 ( Alpha - lipoic acid )
  • 用語解説4. TDM と治療域
  • Column 2. 薬の保管法
  • 7. アロエ・ベラ ( Aloe vera )
  • 8. アンゼリカ ( Angelica )
  • 9. アンドログラフィス ( Andrographis )
  • 10. イチョウ葉 ( Ginkgo )
  • 11. イプリフラボン ( Ipriflavone )
  • 用語解説5. CYP1A2
  • 用語解説6. CYP2C9
  • 用語解説7. CYP2C19
  • 12. イワベンケイ ( Rhodiola )
  • 13. インド長コショウ ( Indian long pepper )
  • 14. ウーロン茶 ( Oolong tea )
  • 15. ウイキョウ ( Fennel )
  • 16. ウコン ( Turmeric )
  • 17. エキナセア ( Echinacea )
  • 18. S - アデノシルメチオニン ( SAM )
  • 19. L - トリプトファン ( L - tryptophan )
  • 用語解説8. セロトニン症候群
  • 20. ω - 3脂肪酸 ( Omega - 3 fatty acid )
  • Column 3. サリドマイド
  • 21. オルリスタット ( Orlistat )
  • 22. カシア・アウリクラタ ( Cassia auriculata )
  • 23. 活性化糖類関連化合物 ( AHCC )
  • 用語解説9. CYP2D6
  • 24. カノコソウ ( Valerian )
  • 25. カバ ( Kava )
  • 用語解説10. GABA 受容体
  • 26. カフェイン ( Caffeine )
  • 用語解説11. リチウム中毒
  • 27. ガラパゴスウチワサボテン ( Prickly pear cactus )
  • 28. カルビシン ( Curbicin )
  • 29. キトサン ( Chitosan )
  • Column 4. 消化性潰瘍治療と抗菌薬
  • 30. キハダ ( Amur corktree )
  • 用語解説12. シクロスポリン、タクロリムス
  • 31. ギムネマ ( Gymnema )
  • Column 5. 糖尿病を合併した高血圧患者に適した降圧薬
  • 32. キャッツクロー ( Cat' s claw )
  • 33. キャラウェイ ( Caraway )
  • 34. グアーガム ( Guar gum )
  • 35. クコ ( Lycium )
  • Column 6. カルシウム拮抗薬と歯肉増殖
  • Column 7. メタボリック症候群
  • 36. クズ ( Kudzu )
  • 37. グッグル ( Guggul )
  • 38. クミン ( Cumin )
  • 39. クランベリー ( Cranberry )
  • Column 8. エコノミークラス症候群の治療薬
  • 40. クリシン ( Chrysin )
  • 41. グルコサミン ( Glucosamine )
  • Column 9. ヒアルロン酸の関節痛改善効果
  • 42. グルタミン ( Glutamine )
  • 43. グレープフルーツ ( Grapefruit )
  • 用語解説13. CYP3A4
  • 44. クレソン ( Watercress )
  • 45. クロレラ ( Chlorella )
  • 46. ケイパーズ ( Capers )
  • 47. 紅茶 ( Black tea )
  • 48. コエンザイム Q10 ( Ubidecarenone )
  • 49. サイリウム ( Psyllium )
  • 50. ザクロ ( Pomegranate )
  • 51. Shengmai - yin
  • 52. ジオスミン ( Diosmin )
  • 53. シナモン ( Cinnamon )
  • 54. ジプシーワート ( Gypsywort )
  • 55. シベリア人参 ( Siberian ginseng )
  • 用語解説14. ジゴキシン中毒
  • 56. ジャーマン・カモミール ( German chamomile )
  • 57. ショウガ ( Ginger )
  • 58. 食物繊維 ( Dietary fiber )
  • Column 10. やせ薬と甲状腺ホルモン
  • 59. スイートクローバー ( Sweet clover )
  • 60. セイヨウトチノキ ( Horse - chestnut )
  • 61. セント・ジョンズ・ワート ( SJW )
  • Column 11. エッセンシャル・ドラッグ
  • 62. 大黄 ( Uzara )
  • 63. 大豆 ( Soy )
  • Column 12. オーファン・ドラッグ
  • 64. タマリンド ( Tamarind )
  • 65. タンジン ( Danshen )
  • 66. チェストベリー ( Chaste berry )
  • 67. チョウセンゴミシ ( Schisandra )
  • 68. 朝鮮人参 ( Panax ginseng )
  • 69. 月見草 ( Evening primrose )
  • 70. 鉄 ( Iron )
  • Column 13. 生活改善薬
  • 71. デビルズクロー ( Devil' s claw )
  • 72. ドンクアイ ( Dong quai )
  • 73. ナットウキナーゼ ( Nattokinase )
  • 74. ナツメッグ ( Nutmeg )
  • 75. ニガウリ ( Bitter melon )
  • 76. 日々草 ( Madagascar periwinkle )
  • Column 14. アスピリンの大腸がん予防効果
  • 77. ニンニク ( Garlic )
  • 78. ハイビスカス ( Hibiscus )
  • 79. パセリ ( Parsley )
  • 80. ヒドラスチス ( Goldenseal )
  • 81. ピペリン ( Piperine )
  • 82. フィーバーフュー ( Feverfew )
  • 83. ブルーコホシュ ( Blue cohosh )
  • 84. ブルーベリー ( Blueberry )
  • 85. 紅麹 ( Red yeast )
  • 用語解説15. スタチン
  • 86. 紅花 ( Safflower )
  • 87. ペパーミントオイル ( Peppermint oil )
  • 88. ポメロ ( Pomelo )
  • 89. ボラージシードオイル ( Borage seed oil )
  • 90. ボルド ( Boldo )
  • 91. マイタケ ( Maitake mushroom )
  • 92. マンゴー ( Mango )
  • 93. ミルクシスル ( Milk thistle )
  • 94. ミロバラン ( Myrobalan )
  • 95. ムラサキツメクサ ( Red clover )
  • 96. メドウスイート ( Meadowsweet )
  • 用語解説16. アスピリン
  • 97. メラトニン ( Melatonin )
  • 98. 葉酸 ( Folic acid )
  • 99. ライム ( Lime )
  • 100. リコリス ( Licorice )
  • 用語解説17. 甘草と偽性アルドステロン症
  • 101. 緑茶 ( Green tea )
  • Column 15. 水溶性スタチンと脂溶性スタチン
  • 102. 霊芝 ( Reishi mushroom )
  • 103. ロイヤルゼリー ( Royal jelly )
  • 索引
  • 奥付

この書籍の参考文献

参考文献のリンクは、リンク先の都合等により正しく表示されない場合がありますので、あらかじめご了承下さい。

本参考文献は電子書籍掲載内容を元にしております。

1. アスコルビン酸 ( Ascorbic acid ) ( ビタミン C )

P.2 掲載の参考文献
1) Dysken MW, et al : Drug interaction between ascorbic acid and fluphenazine. JAMA 241 : 2008, 1979.
PubMed
2) Furlanut M, et al : Possible interaction between aminophylline and ascorbic acid. Br J Clin Pharmacol 19 : 528-529, 1985.
 

2. アフリカン・ワイルド・ポテト ( African wild potato )

P.4 掲載の参考文献
1) Brow L, et al : Impact of traditional medicinal plant extracts on antiretroviral drug absorption. J Ethnopharmacol 119 : 588-592, 2008.
 
2) Mills E, et al : Impact of African herbal medicines on antiretroviral metabolism. AIDS 2005 : 95-97, 2005.
PubMed
3) Nair VD, et al : In vitro evaluation of human cytochrome P450 and P-glycoprotein-mediated metabolism of some phytochemicals in extracts and formulations of African potato. Phytomedicine 14 : 498-507, 2007.
PubMed

3. アミグダリン ( Amygdalin )

P.5 掲載の参考文献
1) Bromley J, et al : Life-threatening interaction between complementary medicines ; cyanide toxicity following ingestion of amygdalin and vitamin C. Ann Pharmacother 39 : 1566-1569, 2005.
PubMed

4. アメリカ人参 ( American ginseng )

P.7 掲載の参考文献
1) Yuan CS, et al : Brief communication ; American ginseng reduces Warfarin's effect in healthy patients ; A randomized, controlled trial. Ann Inter Med 141 : 23-27, 2004.
 
2) Vuksan V, et al : Similar postprandial glycemic reductions with escalation of dose and administration time of American ginseng in type 2 diabetes. Diabetes Care 23 : 1221-1226, 2000.
PubMed

5. アルコール ( Alcohol )

P.8 掲載の参考文献
1) Havrda DE, et al : Enhanced antithrombotic effect of warfarin with low-dose alcohol consumption. Pharmacotherapy 25 : 303-307, 2005.
PubMed

6. α - リポ酸 ( Alpha - lipoic acid )

P.10 掲載の参考文献
1) Phua LC, et al : Investigation of the drug-drug interaction between α-lipolc acid and valproate via mitochondrial β-oxidation. Pharm Res 25 : 2639-2649, 2008.
 

7. アロエ・ベラ ( Aloe vera )

P.11 掲載の参考文献
1) Lee A, et al : Possible interaction between sevoflurane and Aloe vera. Ann Pharmacother 38 : 1651-1654, 2004.
PubMed

8. アンゼリカ ( Angelica )

P.12 掲載の参考文献
1) Ishihara K, et al : Interaction of drugs and Chinese herbs ; pharmacokinetic changes of tolbutamide and diazepam caused by extract of Angelica dahurica. J Pharm Pharmacol 52 : 1023-1029, 2000.
PubMed
2) Yang J, et al : Byakangelicin induces cytochrome P450 3A4 expression via transactivation of pregnane X receptors in human hepatocytes. Br J Pharmacol 162 : 441-451, 2011.
PubMed

9. アンドログラフィス ( Andrographis )

P.13 掲載の参考文献
1) Chien CF, et al : Herb-drug interaction of Andrographis paniculata extract and andrographolide on the pharmacokinetics of theophylline in rats. Chem Biol Interact 184 : 458-465, 2010.
PubMed
2) Chatuphonprasert W, et al : Synergistic increases of metabolism and oxidation-reduction genes on their expression after combined treatment with a CYP1A inducer and andrographolide. Chem Biol Interact 182 : 233-238, 2009.
PubMed

10. イチョウ葉 ( Ginkgo )

P.15 掲載の参考文献
1) Meisel C, et al : Fatal intracerebral mass bleeding associated with Ginkgo biloba and ibuprofen. Atherosclerosis 16 : 367, 2003.
 
2) Kupiec T, et al : Fatal seizures due to potential herb-drug interactions with Ginkgo biloba. J Anal Toxicol 29 : 755-758, 2005.
PubMed
3) Uchida S, et al : Effects of Ginkgo biloba extract on pharmacokinetics and pharmacodynamics of tolbutamide and midazolam in healthy volunteers. J Clin Pharmacol 46 : 1290-1298, 2006.
PubMed
4) Matthews MK : Associatlon of Ginkgo biloba with intracerebral hemorrhage. Neurology 50 : 1933, 1998.
PubMed
5) Galluzzi S, et al : Coma in a patient with Alzheimer's disease taking low dose trazodone and Ginkgo biloba. J Neurol Neurosurg Psychiatry 68 : 679-680, 2000.
 

11. イプリフラボン ( Ipriflavone )

P.17 掲載の参考文献
1) Takahashi J, et al : Elevation of serum theophylline levels by ipriflavone in a patient with chronic obstructive pulmonary disease. Eur J Clin Pharmacol 43 : 207-208, 1992.
 
2) Moon Y, et al : Characterization of cytochrome P450s mediating ipriflavone metabolism in human liver microsomes. Xenobiotica 37 : 246-259, 2007.
PubMed

12. イワベンケイ ( Rhodiola )

P.18 掲載の参考文献
1) Hellum BH, et al : Potent in vitro inhibition of CYP3A4 and P-glycoprotein by Rhodiola rosea. Planta Med 76 : 331-338, 2010.
PubMed

13. インド長コショウ ( Indian long pepper )

P.19 掲載の参考文献
1) Kasibhatta R, et al : Influence of piperine on the pharmacokinetics of nevirapine under fasting conditions ; a randomized crossover, placebo-controlled study. Drugs RD 8 : 383-391, 2007.
 
2) Aher S, et al : Novel pepper extract for enhanced P-glycoprotein inhibition. J Pharm Pharmacol 61 : 1179-1186, 2009.
PubMed

14. ウーロン茶 ( Oolong tea )

P.20 掲載の参考文献
1) Nishimuta H, et al : Inhibitory effects of various beverages on human recombinant sulfotransferase isoforms SULT1A1 and SULT1A3. Biopharm Drug Dispos 28 : 491-500, 2007.
PubMed

15. ウイキョウ ( Fennel )

P.21 掲載の参考文献
1) Subehan, et al : Mechanism-based inhibition of CYP3A4 and CYP2D6 by Indonesian medicinal plants. J Ethnopharmacol 105 : 449-455, 2006.
PubMed

16. ウコン ( Turmeric )

P.22 掲載の参考文献
1) Chen Y, et al : Plant polyphenol curcumin significantly affects CYP1A2 and CYP2A6 activity in healthy, male Chinese volunteers. Ann Pharmacother 44 : 1038-1045, 2010.
PubMed
2) Appiah-Opong R, et al : Inhibition of human recombinant cytochrome P450s by curcumin and curcumin decomposition products. Toxicology 235 : 83-91, 2007.
PubMed

17. エキナセア ( Echinacea )

P.23 掲載の参考文献
1) Modarai M, et al : Metabolomic profiling of liquid Echinacea medicinal products with in vitro inhibitory effects on cytochrome P450 3A4 (CYP3A4). Planta Med 76 : 378-385, 2010.
PubMed
2) Romiti N, et al : P-glycoprotein inhibitory activity of lipophilic constituents of Echinacea pallid roots in a human proximal tubular cell line. Planta Med 74 : 264-266, 2008.
 

18. S - アデノシルメチオニン ( SAM )

P.24 掲載の参考文献
1) Iruela LM, et al : Toxic interaction of S-adenosylmethionine and clomipramine. Am J Psychiatry 150 : 522, 1993.
PubMed

19. L - トリプトファン ( L - tryptophan )

P.26 掲載の参考文献
1) Thomas JM, et al : Case report of a toxic reaction from a combination of tryptophan and phenelzine. Am J Psychiatry 141 : 281-283, 1984.
PubMed
2) Skop BP, et al : The serotonin syndrome associated with paroxetine, an over-counter cold remedy, and vascular disease. Am J Emerg Med 12 : 642-644, 1994.
PubMed

20. ω - 3脂肪酸 ( Omega - 3 fatty acid )

P.28 掲載の参考文献
1) Buckley MS : Fish oil interaction with warfarin. Ann Pharmacother 38 : 50-53, 2004.
PubMed
2) Larson MK, et al : Effects of omega-3 acid ethyl esters and aspirin, alone and in combination, on platelet function in healthy subjects. Thromb Haemost 100 : 634-641, 2008.
PubMed
3) McClaskey EM, et al : Subdural hematoma after a fall in an elderly patient taking high-dose omega-3 fatty acids with warfarin and aspirin ; case report and review of the literature. Pharmacotherapy 27 : 152-160, 2007.
 

21. オルリスタット ( Orlistat )

P.29 掲載の参考文献
1) MacWalter RS, et al : Orlistat enhances warfarin effect. Ann Pharmacother 37 : 510-512, 2003.
PubMed

22. カシア・アウリクラタ ( Cassia auriculata )

P.30 掲載の参考文献
1) Thabrew MI, et al : Effects of Cassla auriculata and Cardospermum halicacabum teas on the steady state blood levels of theophylline in rats. Drug Metabol Drug Interact 20 : 263-272, 2004.
PubMed
2) Thabrew MI, et al : The effects of Cassia auriculata and Cardiospermum halicacabum teas on the steady state blood level and toxicity of carbamazepine. J Ethnopharmacol 90 : 145-150, 2004.
 

23. 活性化糖類関連化合物 ( AHCC )

P.31 掲載の参考文献
1) Mach CM, et al : Evaluation of active hexose correlated compound hepatic metabolism and potential for drug interactions with chemotherapy agents. J Soc Integr Oncol 6 : 105-109, 2008.
PubMed

24. カノコソウ ( Valerian )

P.32 掲載の参考文献
1) Carrasco MC, et al : Interactions of Valeriana officinals L. and Passiflora incarnate L. in a patient treated with lorazepam. Phytother Res 23 : 1795-1796, 2009.
 

25. カバ ( Kava )

P.34 掲載の参考文献
1) Almeida JC, et al : Coma from the health food store ; interaction between kava and alprazolam. Ann Intern Med 125 : 940-941, 1996.
PubMed
2) Singh YN : Potential for interaction of kava and St. John's wort with drugs. J Ethnopharmacol 100 : 108-113, 2005.
PubMed
3) Weiss J, et al : Extracts and kavalactones of Piper metylsticum G. Forst (kava-kava) inhibit P-glycoprotein in vitro. Drug Metab Dispos 33 : 1580-1583, 2005.
PubMed

26. カフェイン ( Caffeine )

P.36 掲載の参考文献
1) Jefferson JW : Lithium tremor and caffeine intake ; two cases of drinking less and shaking more. J Clin Psychiatry 49 : 72-73, 1988.
 
2) Odom-White A, et al : Clozapine levels and caffeine. J Clin Psychiatry 57 : 175-176, 1996.
PubMed
3) Mester R, et al : Caffeine withdrawal increases lithium blood levels. Biol Psychiatry 37 : 348-350, 1995.
PubMed

27. ガラパゴスウチワサボテン ( Prickly pear cactus )

P.37 掲載の参考文献
1) Sobieraj DM, et al : Probable hypoglycemic adverse drug reaction associated with prickly pear cactus, glipizide, and metformin in a patient with type 2 diabetes mellitus. Ann Pharmacother 44 : 1334-1337, 2010.
 

28. カルビシン ( Curbicin )

P.38 掲載の参考文献
1) Yue QY, et al : Herbal drug curbicin and anticoagulant effect with and without warfarin ; possibly related to the vitamin E component. J Am Geriatr Soc 49 : 838, 2001.
 

29. キトサン ( Chitosan )

P.40 掲載の参考文献
1) Striano P, et al : Chitosan may decrease serum valproate and increase the risk of seizure reappearance. BMJ 339 : b3751, 2009.
PubMed
2) Huang SS, et al : Chitosan potentiation of warfarin effect. Ann Pharmacother 41 : 1912-1914, 2007.
PubMed

30. キハダ ( Amur corktree )

P.41 掲載の参考文献
1) Chen HY, et al : Marked decrease of cyclosporine absorption caused by phellamurin in rats. Planta Med 68 : 138-141, 2002.
PubMed

31. ギムネマ ( Gymnema )

P.42 掲載の参考文献
1) Al-Romaiyan A, et al : A novel Gymnema sylvestre extract stimulates insulin secretion from islets in vivo and in vitro. Phytother Res 24 : 1370-1376, 2010.
PubMed
2) Nagai M, et al : Inhibitory effects of herbal extracts on the actrvity of human sulfotransferase isoform sulfotransferase 1A3 (SULT1A3). Biol Pharm Bull 32 : 105-109, 2009.
 

32. キャッツクロー ( Cat' s claw )

P.44 掲載の参考文献
1) Lopez RM, et al : Interaction between cat's claw and protease inhibitors atazanavir, ritonavir and saquinavir. Eur J Clin Pharmacol 64 : 1235-1236, 2008.
 
2) Budzinski JW, et al : An in vitro evaluation of human cytochrome P4503A4 inhibition by selected commercial herbal extracts and tinctures. Phytomedicine 7 : 273-282, 2000.
 

33. キャラウェイ ( Caraway )

P.45 掲載の参考文献
1) Sachin BS, et al : Pharmacokinetic interaction of some antituberculardrugs with caraway ; implications in the enhancement of drug bioavailability. Hum Exp Toxicol 28 : 175-184, 2009.
 

34. グアーガム ( Guar gum )

P.46 掲載の参考文献
1) Scheen AJ : Clinical pharmacokinetics of metformin. Clin Pharmacokinet 30 : 359-371, 1996.
PubMed

35. クコ ( Lycium )

P.48 掲載の参考文献
1) Leung H, et al : Warfarin overdose due to the possible effects of Lycium barbarum L. Food Chem Toxicol 46 : 1860-1862, 2008.
 
2) Lam AY, et al : Possible interaction between warfarin and Lycium barbarum L. Ann Pharmacother 35 : 1199-1201, 2001.
PubMed

36. クズ ( Kudzu )

P.49 掲載の参考文献
1) Zheng J, et al : The effects of puerarin on CYP2D6 and CYP1A2 activities in vivo. Arch Pharm Res 33 : 243-246, 2010.
PubMed
2) Chiang HM, et al : Life-threatening interaction between the root extract of Purraria lobata and methotrexate in rats. Toxicol Appl Pharmaco1 209 : 263-268, 2005.
PubMed
3) Wong KH, et al : Kudzu ; Traditional uses and potential medicinal benefits in diabetes and cardiovascular diseases. J Ethnopharmacol 134 : 584-607, 2011.
PubMed

37. グッグル ( Guggul )

P.50 掲載の参考文献
1) Brobst DE, et al : Guggulsterone activates multiple nuclear receptors and induces CYP3A gene expression through the pregnane X receptor. J Pharmacol Exp Ther 310 : 528-535, 2004.
PubMed
2) Nabekura T, et al : Effects of plant sterols on human multidrug transporters ABCB1 and ABCC1. Biochem Blophys Res Commun 369 : 363-368, 2008.
PubMed

38. クミン ( Cumin )

P.51 掲載の参考文献
1) Sachin BS, et al : Herbal modulation of drug bioavailability ; enhancement of rifampicin levels in plasma by herbal products and a flavonoid glycoside derived from Cuminum cyminum. Phytother Res 21 : 157-163, 2007.
 
2) Jagtap AG, et al : Antihyperglycemic activity and inhibition of advanced glycation end product formation by Cuminum cyminum in streptozotocin induced diabetic rats. Food Chem Toxicol 48 : 2030-2036, 2010.
PubMed

39. クランベリー ( Cranberry )

P.53 掲載の参考文献
1) Rindone JP, et al : Warfarin-cranberry juice interaction resulting in profound hypoprothrombinemia and bleeding. Am J Ther 13 : 283-284, 2006.
PubMed
2) Ushijima K, et al : Cranberry juice suppressed the diclofenac metabolism by human liver microsomes, but not in healthy human subjects. Br J Clin Pharmacol 68 : 194-200, 2009.
 
3) Mohammed Abdul MI, et al : Pharmacodynamic interaction of warfarin with cranberry but not with garlic in healthy subjects. Br J Pharmacol 154 : 1691-1700, 2008.
 
4) Suvarna R, et al : Possible interaction between warfarin and cranberry juice. Br Med J 327 : 1454, 2003.
 

40. クリシン ( Chrysin )

P.54 掲載の参考文献
1) Si D, et al : Mechanism of CYP2C9 inhibition by flavones and flavonols. Drug Metab Dispos 37 : 629-634, 2009.
PubMed

41. グルコサミン ( Glucosamine )

P.56 掲載の参考文献
1) Knudsen JF, et al : Potential glucosamine-warfarin interaction resulting in increased international normalized ratio ; case report and review of the literature and Med Watch database. Pharmacotherapy 28 : 540-548, 2008.
 

42. グルタミン ( Glutamine )

P.57 掲載の参考文献
1) Pozo JFM, et al : Hazards of concomitant administration of methotrexate and glutamine. Am J Health-Syst Pharm 67 : 601-602, 2010.
 
2) Welbourne T, et al : An oral glutamine load enhances renal acid secretion and function. Am J Clin Nutr 67 : 660-663, 1998.
PubMed

43. グレープフルーツ ( Grapefruit )

P.59 掲載の参考文献
1) Spence JD : Drug interactions with grapefruit ; Whose responsibility is it to warn the public? Clin Pharmacol Ther 61 : 395-400, 1997.
PubMed

44. クレソン ( Watercress )

P.60 掲載の参考文献
1) Leclercq I, et al : Inhibition of chlorzoxazone metabolism, a clinical probe for CYP2E1, by a single ingestion of watercress. Clin Pharmacol Ther 64 : 144-149, 1998.
PubMed

45. クロレラ ( Chlorella )

P.61 掲載の参考文献
1) Ohkawa S, et al : Warfarin therapy and chlorella. Rinsho Shinkeigaku 35 : 806-807, 1995.
PubMed

46. ケイパーズ ( Capers )

P.62 掲載の参考文献
1) Eddouks M, et al : Caraway and caper ; potential anti-hyperglycaemic plants in diabetic rats. J Ethnopharmacol 94 : 143-148, 2004.
PubMed

47. 紅茶 ( Black tea )

P.63 掲載の参考文献
1) Parker DL, et al : Interaction between warfarin and black tea. Ann Pharmacother 43 : 150-151, 2009.
PubMed

48. コエンザイム Q10 ( Ubidecarenone )

P.64 掲載の参考文献
1) Spigset O : Reduced effect of warfarin caused by ubidecarenone. Lancet 344 : 1372-1373, 1994.
PubMed

49. サイリウム ( Psyllium )

P.65 掲載の参考文献
1) Perlman BB, et al : Interaction between lithium salts and ispaghula husk. Lancet 17 : 416, 1990.
 

50. ザクロ ( Pomegranate )

P.67 掲載の参考文献
1) Sorokin AV, et al : Rhabdomyolysis with pomegranate juice consumption. Am J Cardiol 98 : 705-706, 2006.
PubMed
2) Jarvis S, et al : Possible interaction between pomegranate and warfarin. Emerg Med J 27 : 74-75, 2010.
PubMed
3) Hidaka M, et al : Effects of pomegranate juice on human cytochrome P450 3A (CYP3A) and carbamazepine pharmacokinetics in rats. Drug Metab Dispos 33 : 644-648, 2005.
PubMed
4) Nagata M, et al : Effects of pomegranate juice on human cytochrome P450 2C9 and tolbutamide pharmacokinetics in rats. Drug Metab Dispos 35 : 302-305, 2007.
PubMed

51. Shengmai - yin

P.68 掲載の参考文献
1) Su Q, et al : Interaction between warfarin and the herbal product Shengmai-yin ; a case report of intracerebral hematoma. Yonsi Med J 51 : 793-796, 2010.
 

52. ジオスミン ( Diosmin )

P.69 掲載の参考文献
1) Rajnarayana K, et al : Influence of diosmin pretreatment on the pharmacokinetics of chlorzoxazone in healthy male volunteers. Drug Metabol Drug Interact 23 : 311-321, 2008.
PubMed
2) Rajnarayana K, et al : Bioavailability of diclofenac sodium after pretreatment with diosmin in healthy volunteers. Drug Metabol Drug Interact 22 : 165-174, 2007.
PubMed

53. シナモン ( Cinnamon )

P.70 掲載の参考文献
1) Kirkham S, et al : The potential of cinnamon to reduce blood glucose levels in patients with type 2 diabetes and insulin resistance. Diabetes Obes Metab 11 : 1100-1113, 2009.
PubMed
2) Lu Z, et al : Hypoglycemic activities of A- and B-type procyanidin oligomer-rich extracts from different cinnamon barks. Phytomedicine 18 : 298-302, 2011.
 

54. ジプシーワート ( Gypsywort )

P.71 掲載の参考文献
1) Beer AM, et al : Lycopus europaeus (Gypsywort) ; effects on the thyroidal parameters and symptoms associated with thyroid function. Phytomedicine 15 : 16-22, 2008.
PubMed

55. シベリア人参 ( Siberian ginseng )

P.73 掲載の参考文献
1) McRae S : Elevated serum digoxin levels in a patient taking digoxin and Siberian ginseng. Can Med Assoc J 155 : 293-295, 1996.
 
2) Dasgupta A, et al : Effect of Asian and Siberian ginseng on serum digoxin measurement by five digoxin immunoassays ; Significant variation in digoxin-like immunoreactivity among commercial ginsengs. Am J Clin Pathol 119 : 298-303, 2003.
PubMed

56. ジャーマン・カモミール ( German chamomile )

P.74 掲載の参考文献
1) Segal R, et al : Warfarin interaction with Matricaria chamomilla. CMAJ 25 : 1281-1282, 2006.
 
2) Ganzera M, et al : Inhibitory effects of the essential oil of chamomile (Matricaria recutita L.) and its major constituents on human cytochrome P450 enzymes. Life Sci 78 : 856-861, 2006.
PubMed

57. ショウガ ( Ginger )

P.75 掲載の参考文献
1) Kruth P, et al : Ginger-associated overanticoagulation by phenprocoumon. Ann Pharmacother 38 : 257-260, 2004.
PubMed
2) Vaes LP, et al : Interactions of warfarin with garlic, ginger, ginkgo, or ginseng ; nature of the evidence. Ann Pharmacother 34 : 1478-1482, 2000.
PubMed

58. 食物繊維 ( Dietary fiber )

P.76 掲載の参考文献
1) Liel Y, et al : Evidence for a clinically important adverse effect of fiber-enriched diet on the bioavalability of levothyroxine in adult hypothyroid patients. J Clin Endocrinol Metab 81 : 857-859, 1996.
 

59. スイートクローバー ( Sweet clover )

P.77 掲載の参考文献
1) Heck AM, et al : Potential interactions between alternative therapies and warfarin. Am J Health Syst Pharm 57 : 1221-1227, 2000.
PubMed

60. セイヨウトチノキ ( Horse - chestnut )

P.78 掲載の参考文献
1) Hellum BH, et al : In vitro inhibition of CYP3A4 metabolism and P-glycoprotein-mediated transport by trade herbal products. Basic Clin Pharmacol Toxicol 102 : 466-475, 2008.
PubMed

61. セント・ジョンズ・ワート ( SJW )

P.80 掲載の参考文献
1) Ruschitzka F, et al : Acute heart transplant rejection due to Saint John's Wort. Lancet 355 : 548-549, 2000.
PubMed
2) Schwart UI, et al : Unwanted pregnancy on self-medication with Saint John's Wort despite hormone contraception. Br J Clin Pharmacol 55 : 112-113, 2003.
 
3) Izzo AA, et al : Possible interaction between herbal medications and prescribed drugs ; A systemic review. Drugs 61 : 2163-2175, 2001.
 

62. 大黄 ( Uzara )

P.81 掲載の参考文献
1) Thurmann PA, et al : Interference of Uzara glycosides in assays of digitalis glycosides. Int J Pharmacol Ther 42 : 281-284, 2004.
 

63. 大豆 ( Soy )

P.83 掲載の参考文献
1) Bell DS, et al : Use of soy protein supplement and resultant need for increased dose of levothyroxine. Endocr Pract 7 : 193-194, 2001.
PubMed
2) Cambria-Kiely JA : Effect of soy milk on warfarin efficacy. Ann Pharmacother 36 : 1893-1896, 2002.
PubMed

64. タマリンド ( Tamarind )

P.84 掲載の参考文献
1) Mustapha IA, et al : Effect of Tamarindus indica L. on the bioavailability of aspirin in healthy volunteers. Eur J Drug Metab Pharmacokinet 21 : 223-226, 1996,
 
2) Garba M, et al : Effect of Tamarindus indica L. on the bioavailability of ibuprofen in healthy volunteers. Eur J Drug Metab Pharmacokinet 28 : 179-184, 2003.
 

65. タンジン ( Danshen )

P.85 掲載の参考文献
1) Izzat MB, et al : A taste of Chinese Medicine. Ann Thorac Surg 66 : 941-942, 1998.
PubMed
2) Wu WW, et al : Inhibition of warfarin hydroxylation by major tanshinones of Danshen (Salvia miltiorrhiza) in the rat in vitro and in vivo. Phytomedicine 17 : 219-226, 2010.
PubMed

66. チェストベリー ( Chaste berry )

P.86 掲載の参考文献
1) Ho SH, et al : The effects of commercial preparations of herbal supplements commonly used by women on the biotransformation of fluorogenic substrates by human cytochromes P450. Phytother Res 25 : 983-989, 2011.
PubMed

67. チョウセンゴミシ ( Schisandra )

P.87 掲載の参考文献
1) Xin HW, et al : Effects of Schisandra sphenanthera extract on the pharmacokinetics of tacrolimus in healthy volunteers. Br J Clin Pharmacol 64 : 469-475, 2007.
PubMed
2) Yoo HH, et al : Effects of Schisandra lignans on P-glycoprotein-mediated drug efflux in human intestinal Caco-2. Planta Med 73 : 444-450, 2007.
 

68. 朝鮮人参 ( Panax ginseng )

P.88 掲載の参考文献
1) Bilgi N, et al : Imatinib and Panax ginseng ; a potential interaction resulting in liver toxicity. Ann Pharmacother 44 : 926-928, 2010.
PubMed
2) Rosado MF : Thrombosis of a prosthetic aortic valve disclosing a hazardous interaction between warfarin and a commercial ginseng product. Cardiology 99 : 111, 2003.
 

69. 月見草 ( Evening primrose )

P.89 掲載の参考文献
1) Zou L, et al : Effects of herbal components on cDNA-expressed cytochrome P450 enzyme catalytic activity. Life Sci 71 : 1579-1589, 2002.
PubMed

70. 鉄 ( Iron )

P.91 掲載の参考文献
1) Fiaux E, et al : Hypothyroidism as the result of drug interaction between ferrous sulfate and levothyroxine. Rev Med Interne 31 : e4-e5, 2010.
PubMed
2) Mallet L, et al : Coadministration of gatifloxacin and multivitamin preparation containing minerals ; potential treatment failure in an elderly patient. Ann Pharmacother 39 : 150-152, 2005.
 

71. デビルズクロー ( Devil' s claw )

P.92 掲載の参考文献
1) Unger M, et al : Simultaneous determination of the inhibitory potency of herbal extracts on the activity of six major cytochrome P450 enzymes using liquid chromatography/mass spectrometry and automated online extraction. Rapid Commun Mass Spectrom 18 : 2273-2281, 2004.
PubMed
2) Romiti N, et al : Effects of Devil's Claw (Harpagophytum procumbens) on the multidrug transporter ABCB1/P-glycoprotein. Phytomedicine 16 : 1095-1100, 2009.
PubMed

72. ドンクアイ ( Dong quai )

P.93 掲載の参考文献
1) Page RL, et al : Potentiation of warfarin by dong quai. Pharmacotherapy 19 : 870-876, 1999.
 
2) Lo AC, et al : Danggui (Angelica sinensis) affects the pharmacodynamics but not the pharmacokinetics of warfarin in rabbits. Eur J Drug Metab Pharmacokinet 20 : 55-60, 1995.
 

73. ナットウキナーゼ ( Nattokinase )

P.94 掲載の参考文献
1) Chang YY, et al : Cerebellar hemorrhage provoked by combined use of nattokinase and aspirin in a patient with cerebral microbleeds. Inter Med 47 : 467-469, 2008.
 

74. ナツメッグ ( Nutmeg )

P.95 掲載の参考文献
1) Kimura Y, et al : Effects of mace and nutmeg on human cytochrome P450 3A4 and 2C6 activity. Biol Pharm Bull 33 : 1977-1982, 2010.
 

75. ニガウリ ( Bitter melon )

P.96 掲載の参考文献
1) Aslam M, et al : Interaction between curry ingredient (karela) and drug (chlorpropamide). Lancet 1 : 607, 1979.
PubMed

76. 日々草 ( Madagascar periwinkle )

P.98 掲載の参考文献
1) Wu ML, et al : Severe bone marrow depression induced by an anticancer herb Cantharanthus roseus. J Toxicol Clin Toxicol 42 : 667-671, 2004.
PubMed
2) Usia T, et al : CYP3A4 and CYP2D6 inhibitory activities of Indonesian medicinal plants. Phytomedicine 13 : 67-73, 2006.
PubMed

77. ニンニク ( Garlic )

P.99 掲載の参考文献
1) Piscitelli SC, et al : The effect of garlic supplements on the pharmacokinetics of saquinavir. Clin Infect Dis 34 : 234-238, 2002.
PubMed
2) Gallicano K, et al : Effect of short-term administration of garlic supplements on single-dose ritonavir pharmacokinetics in healthy volunteers. Br J Clin Pharmacol 55 : 199-202, 2003.
PubMed
3) Sunter W : Warfarin and garlic. Pharmaceutical J 246 : 722, 1991.
 

78. ハイビスカス ( Hibiscus )

P.100 掲載の参考文献
1) Fakeye TO, et al : Effects of water extract of Hibiscus sabdariffa, Linn (Malvaceae) 'Roselle' on excretion of a diclofenac formulation. Phytother Res 21 : 96-98, 2007.
PubMed
2) Ndu OO, et al : Herb-drug interaction between the extract of Hibiscus sabdariffa L. and hydrochlorothizide in experimental animals. J Med Food 14 : 640-644, 2011.
 

79. パセリ ( Parsley )

P.101 掲載の参考文献
1) Jakovljevic V, et al : The effect of celery and parsley juices on pharmacodynamic activity of drugs involving cytochrome P450 in their metabolism. Eur J Drug Metab Pharmacokinet 27 : 153-156, 2002.
PubMed

80. ヒドラスチス ( Goldenseal )

P.102 掲載の参考文献
1) Liu R, et al : The effect of natural health products and traditional medicines on the activity of human hepatic microsomal-mediated metabolism of oseltamivir. J Pharm Pharm Sci 13 : 43-55, 2010.
PubMed
2) Gurley BJ, et al : Supplementation with goldenseal (Hydrastis Canadensis), but not kava kava (Piper methysticum), inhibits human CYP3A activity in vivo. Clin Pharmacol Ther 83 : 61-69, 2008.
 
3) Gurley BJ, et al : Clinical assessment of CYP2D6-mediated herb-drug interactions in humans ; effects of milk thistle, black cohosh, gOldenseal, kava kava, St. John's wort, and Echinacea. Mol Nutr Food Res 52 : 755-763, 2008.
PubMed

81. ピペリン ( Piperine )

P.103 掲載の参考文献
1) Pattanaik S, et al : Effect of piperine on the steady-state pharmacokinetics of phenytoin in patients with epilepsy. Phytother Res 20 : 683-686, 2006.
PubMed
2) Kasibhatta R, et al : Influence of piperine on the pharmacokinetics of nevirapine under fasting conditions ; a randomized, crossover, placebo-controlled study. Drugs RD 8 : 383-391, 2007.
 
3) Rajinder K, et al : Piperine, a major constituent of black pepper, inhibits human P-glycoprotein and CYP3A4. J Pharmacol Exp Ther 302 : 645-650, 2002.
 

82. フィーバーフュー ( Feverfew )

P.104 掲載の参考文献
1) Unger M, et al : Simultaneous determination of the inhibitory potency of herbal extracts on the activity of six major cytochrome P450 enzymes using liquid chromatography/mass spectrometry and automated online extraction. Rapid Commun Mass Spectrom 18 : 2273-2281, 2004.
PubMed

83. ブルーコホシュ ( Blue cohosh )

P.105 掲載の参考文献
1) Madgula VL, et al : Alkaloids and saponins as cytochrome P450 inhibitors from blue cohosh (Caulophyllum thalictroides) In an in vitro assay. Planta Med 75 : 329-332, 2009.
 

84. ブルーベリー ( Blueberry )

P.106 掲載の参考文献
1) Iwao K, et al : Physicochemical interactions of metformin hydrochloride and glibenclamide with several health foods. Yakugaku Zasshi 128 : 1341-1345, 2008.
PubMed

85. 紅麹 ( Red yeast )

P.108 掲載の参考文献
1) Prasad GV, et al : Rhabdomyolysis due to red yeast rice (Monascus purpureus) in a renal transplant recipient. Transplantation 74 : 1200-1201, 2002.
 

86. 紅花 ( Safflower )

P.109 掲載の参考文献
1) Li Y, et al : Antithrombotic effects of Danggui, Honghua and potential drug interaction with clopidogrel. J Ethnopharmacol 128 : 623-628, 2010.
PubMed

87. ペパーミントオイル ( Peppermint oil )

P.110 掲載の参考文献
1) Unger M, et al : Simultaneous determination of the inhibitory potency of herbal extracts on the activity of six major cytochrome P450 enzymes using liquid chromatography/mass spectrometry and automated online extraction. Rapid Commun Mass Spectrom 18 : 2273-2281, 2004.
PubMed

88. ポメロ ( Pomelo )

P.111 掲載の参考文献
1) Egashira K, et al : Pomelo-induced increase in the blood level of tacrolimus in a renal transplant patient. Transpiantation 75 : 1057, 2003.
 
2) Egashira K, et al : Inhibitory effects of pomelo On the metabolism of tacrolimus and the activities of XCYP3A4 and P-glycoprotein. Drug Metab Dispos 32 : 828-833, 2004.
 
3) Grenier J, et al : Pomelo juice, but not cranberry juice, affects the pharmacokinetics of cyclosporine in humans. Clin Pharmacol Ther 79 : 255-262, 2006.
 

89. ボラージシードオイル ( Borage seed oil )

P.112 掲載の参考文献
1) Heck AM, et al : Potential interactions between alternative therapies and warfarin. Am J Health Syst Pharm 57 : 1221-1227, 2000.
PubMed

90. ボルド ( Boldo )

P.113 掲載の参考文献
1) Lambert JP, et al : Potential interaction between warfarin and boldo-fenugreek. Pharmacotherapy 21 : 509-512, 2001.
PubMed
2) Teng CM, et al : Antiplatelet effects of some aporphine and phenanthrene alkaloids in rabbits and man. J Pharm Pharmacol 49 : 706-711, 1997.
 

91. マイタケ ( Maitake mushroom )

P.114 掲載の参考文献
1) Hanselin MR, et al : INR elevation with maitake extract in combination with warfarin. Ann Pharmacother 44 : 223-224, 2010.
PubMed

92. マンゴー ( Mango )

P.115 掲載の参考文献
1) Monterrey-Rodriguez J, et al : Interaction between warfarin and mango fruit. Ann Pharmacother 36 : 940-941, 2002.
PubMed
2) Yamazaki H, et al : Effects of arachidonic acid, prostaglandins, retinol, retinoic acid and cholecalciferol on xenobiotic oxidations catalysed by human cytochrome P450 enzymes. Xenobiotica 29 : 231-241, 1999.
PubMed

93. ミルクシスル ( Milk thistle )

P.116 掲載の参考文献
1) Doehmer J, et al : Assessment of a dry extract from milk thistle (Silybum marianum) for interference with human liver cytochrome-P450 activities. Toxicol In Vitro 25 : 21-27, 2011.
PubMed
2) Brantley SJ, et al : Two flavonolignans from milk thistle (Silybum marianum) inhibit CYP2C9-mediated warfarin metabolism at clinically achievable concentrations. J Pharmacol Exp Ther 332 : 1081-1087, 2010.
PubMed

94. ミロバラン ( Myrobalan )

P.117 掲載の参考文献
1) Prasad KP, et al : Recurrent relapses of depression in a patient established on sertraline after taking herbal medicinal mlxtures ; a herbal-drug interaction? J Psychopharmacol 23 : 216-219, 2009.
 

95. ムラサキツメクサ ( Red clover )

P.118 掲載の参考文献
1) Budzinski JM, et al : An in vitro evaluation of human cytochrome P450 inhibition by selected commercial herbal extracts and tinctures. Phytomedicine 7 : 273-282, 2000.
 

96. メドウスイート ( Meadowsweet )

P.119 掲載の参考文献
1) Abebe W : Herbal medication ; potential for adverse interactions with analgesic drugs. J Clin Pharm Ther 27 : 391-401, 2002.
PubMed

97. メラトニン ( Melatonin )

P.120 掲載の参考文献
1) Lehman NL, et al : Toxic optic neuropathy after concomitant use of melatonin, Zoloft, and a high-protein diet. J Neuroophthalmol 19 : 232-234, 1999.
 

98. 葉酸 ( Folic acid )

P.121 掲載の参考文献
1) Berg MJ, et al : Phenytoin and folic acid ; individualized drug-drug Interaction. Ther Drug Monit 5 : 395-399, 1983.
PubMed

99. ライム ( Lime )

P.122 掲載の参考文献
1) Bailey DG, et al : Bergamottin, lime juice, and red wine as inhibitors of cytochrome P450 activity ; comparison with grapefruit juice. Clin Pharmacol Ther 73 : 529-537, 2003.
PubMed

100. リコリス ( Licorice )

P.124 掲載の参考文献
1) Harada T, et al : Congestive heart failure caused by digitalis toxicity in an elderly man taking a licorice-containing Chinese herbal laxative. Cardiology 98 : 218, 2002.
 
2) Satoh T, et al : Effects of Kampo medicines on P-glycoprotein. Biol Pharm Bull 32 : 2018-2021, 2009.
 
3) Li HY, et al : In vitro and in vivo inhibitory effects of glycyrrhetinic acid on cytochrome P450 3A activity. Pharmacology 86 : 287-292, 2010.
PubMed

101. 緑茶 ( Green tea )

P.126 掲載の参考文献
1) Werba JP, et al : The effect of green tea on simvastatin tolerability. Ann Inter Med 149 : 286-287, 2008.
 

102. 霊芝 ( Reishi mushroom )

P.127 掲載の参考文献
1) Wang X, et al : Effects of Ganoderma lucidum polysaccharide on CYP2E1, CYP1A2 and CYP3A activities in BCG-immune hepatic injury in rats. Biol Pharm Bull 30 : 1702-1706, 2007.
PubMed

103. ロイヤルゼリー ( Royal jelly )

P.128 掲載の参考文献
1) Lee NJ, et al : Warfarin and royal jelly interaction. Pharmacotherapy 26 : 583-586, 2006.
PubMed

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