HOME
>
臨床医学：外科
>
眼科学
> 専門医のための眼科診療クオリファイ　19　ドライアイ　スペシャリストへの道

専門医のための眼科診療クオリファイ　19　ドライアイ　スペシャリストへの道

出版社：	中山書店
著者：	大鹿哲郎大橋裕一(シリーズ総編集) 横井則彦(編)
発行日：	2013-11-05
分野：	臨床医学：外科 > 眼科学
ISBN：	9784521734774
シリーズ：	専門医のための眼科診療クオリファイ
電子書籍版：	2013-11-05 （初版第1刷）

書籍・雑誌

≪全国送料無料でお届け≫

取寄せ目安：8～14営業日

15,950 円(税込)

購入する

電子書籍

章別単位での購入はできません

ブラウザ、アプリ閲覧

15,950 円(税込)

購入する

商品紹介

ドライアイは，わが国でも1500万人とも言われる患者数を抱える一般的な眼科疾患。本巻では、発症メカニズム、起因にもとづく病型と重症度の判定、および新薬を含めた治療を網羅した。エキスパートが診療の現場で使いやすいように、ここ最近の基礎研究に裏打ちされた情報をまとめて構成した手引書。

目次

専門医のための眼科診療クオリファイ　19
ドライアイ　スペシャリストへの道

―目次―

1．初学者への道しるべ
2．涙液層にかかわる眼組織と涙液層の層別機能
3．涙液動態と病態とのかかわり
4．定義、診断基準、分類、疫学
5．一般外来検査
6．特殊検査
7．コア・メカニズムの考えかたと治療
8．上流のリスクとその治療／涙液減少
9．上流のリスクとその治療／蒸発亢進
10．上流のリスクとその治療／瞬目時の摩擦亢進
11．上流のリスクとその治療／眼表面上皮の水漏れ性低下
12．複合リスク
13．眼表面疾患とドライアイ

この書籍の参考文献

参考文献のリンクは、リンク先の都合等により正しく表示されない場合がありますので、あらかじめご了承下さい。

本参考文献は電子書籍掲載内容を元にしております。

1 初学者への道しるべ

P.2 掲載の参考文献

1 The definition and classification of dry eye disease : report of the Definition and Classification Subcommittee of the International Dry Eye WorkShop (2007). Ocul Surf 2007 ; 5 : 75-92.

2 島崎潤 (ドライアイ研究会) : 2006年ドライアイ診断基準. あたらしい眼科 2007 ; 24 : 181-184.

3 Koh S, et al : Serial measurements of higher-order aberrations after blinking in patients with dry eye. Invest Ophthalmol Vis Sci 2008 ; 49 : 133-138.

4 Kaido M, et al : Corneal fluorescein staining correlates with visual function in dry eye patients. Invest Ophthalmol Vis Sci 2011 ; 52 : 9516-9522.

5 Sakane Y, et al : Development and validation of the Dry Eye-related Quality of life Score (DEQS). JAMA Ophthalmology (in press).

6 Uchino Y, et al : Changes in dry eye diagnostic status following implementation of revised Japanese dry eye diagnostic criteria. Jpn J Ophthalmol 2012 ; 56 : 8-13.

7 横井則彦ら : ドライアイのコア・メカニズム-涙液安定性仮説の考え方. あたらしい眼科 2012 ; 29 : 291-297.

8 Cher I : Blink-related microtrauma : when the ocular surface harms itself. Clin Experimental Ophthalmology 2003 ; 31 : 183-190.

9 Korb DR, et al : Lid wiper epitheliopathy and dry eye symptoms. Eye Contact Lens 2005 ; 31 : 2-8.

10 Szczesna DH, et al : Lateral shearing interferometry, dynamic wavefront sensing, and highspeed videokeratoscopy for noninvasive assessment of tear film surface characteristics : a comparative study. J Biomed Opt 2010 ; 037005.

11 Ishibashi T, et al : Comparison of the short-term effects on the human corneal surface of topical timolol maleate with and without benzalkonium cloride. J Glaucoma 2003 ; 12 : 486-490.

12 Goto T, et al : A new method for tear film stability analysis using videokeratography. Am J Ophthalmol 2003 ; 135 : 607-612.

13 Sakai E, et al : Blepharo-tensiometer : new eyelid pressure measurement system using tactile pressure sensor. Eye Contact Lens 2012 ; 38 : 326-330.

14 Higashihara H, et al : Using synthesized onion lachrymatory factor to measure age-related decreases in reflex-tear secretion and ocular-surface sensation. Jpn J Ophthalmol 2010 ; 54 : 215-220

15 横井則彦 : ドライアイの新しい治療戦略-眼表面の層別治療. 日本の眼科 2012 ; 83 : 1318-1322.

16 Liu H, et al : A link between tear instability and hyperosmolarity in dry eye. Invest Ophthalmol Vis Sci 2009 ; 50 : 3671-3679.

17 Stern ME, et al : Inflammation in dry eye. Ocul Surf 2004 ; 2 : 124-130.

18 Lemp MA, et al : Tear osmolarity in the diagnosis and management of dry eye disease. Am J Ophthalmol 2011 ; 151 : 792-798.

19 Takamura E, et al : A randomised, double-masked comparison study of diquafosol versus sodium hyaluronate ophthalmic solutions in dry eye patients. Br J Ophthalmol 2012 ; 96 : 1310-1315.

20 Kinoshita S, et al : Rebamipide (OPC-12759) in the treatment of dry eye : a randomized, double-masked, multicenter, placebo-controlled phase II study. Ophthalmology 2012 ; 119 : 2471-2478.

21 加藤弘明ら : ムチンの産生を増やす治療. あたらしい眼科 2013 ; 29 : 329-332.

2 涙液層にかかわる眼組織と涙液層の層別機能

P.10 掲載の参考文献

1 Korb DR, et al : Lid wiper epitheliopathy and dry eye symptoms. Eye Contact Lens 2005 ; 31 : 2-8.

2 Marx E : Uber vitale Farbung des Auges und der Augenlider. I. Uber Anatomie, Physiologie und Pathologie des Augenlidrandes und der Tranenpunkte. Grafes Archv f Ophthalmol 1924 ; 114 : 465-482.

3 白石敦ら : ドライアイ症状患者におけるlid-wiper epitheliopathyの発現頻度. 日本眼科学会雑誌 2009 ; 113 : 596-600.

P.14 掲載の参考文献

1 Marx E : Uber vitale Farbung des Auges und der Augenlider. I. Uber Anatomie, Physiologie und Pathologie des Augenlidrandes und der Tranenpunkte. Grafes Archv f Ophthalmol 1924 ; 114 : 465-482.

2 Knop E, et al : The lid wiper and muco-cutaneous junction anatomy of the human eyelid margins : an in vivo confocal and histological study. J Anat 2011 ; 218 : 449-461.

3 Bron AJ, et al : A solute gradient in the tear meniscus. I. A hypothesis to explain Marx's line. Ocul Surf 2011 ; 9 : 70-91.

4 Norn MS : Meibomian orifices and Marx's line. Studied by triple vital staining. Acta Ophtalmol 1985 ; 63 : 698-700.

5 Yamaguchi M, et al : Marx line : fluorescein staining line on the inner lid as indicator of meibomian gland function. Am J Ophthalmol 2006 ; 141 : 669-675.

6 広谷有美ら : 下眼瞼皮膚粘膜接合部及び結膜弛緩症の程度の加齢性変化と両者の関連. 日本眼科学会雑誌 2003 ; 107 : 363-368.

P.17 掲載の参考文献

1 Draper CE, et al : Evidence to suggest morphological and physiological alterations of lacrimal gland acini with aging. Experimental eye research 1999 ; 68 : 265-276.

2 Kawashima M, et al : Effect of calorie restriction on change in lacrimal gland with age. Cornea 2011 ; 30 : S29-33.

3 Kawashima M, et al : Dietary lactoferrin alleviates age-related lacrimal gland dysfunction in mice. PLoS ONE 2012 ; 7 : e33148.

4 Hill RE, et al : Mouse small eye results from mutations in a paired-like homeobox-containing gene. Nature 1991 ; 354 : 522-525.

5 Govindarajan V, et al : Endogenous and ectopic gland induction by FGF-10. Dev Biol 2000 ; 225 : 188-200.

6 Dean C, et al : Bmp7 regulates branching morphogenesis of the lacrimal gland by promoting mesenchymal proliferation and condensation. Development 2004 ; 131 : 4155-4165.

7 Hirayama M, et al : Functional lacrimal gland regeneration by transplantation of a bioengineered organ germ. Nat Commun 2013 DOI : 10.1038/ncomms3497.

8 Moore M, et al : Tear secretion by lacrimal glands in transgenic mice lacking water channels AQP1, AQP3, AQP4 and AQP5. Exp Eye Res 2000 ; 70 : 557-562.

9 Ohashi Y, et al : Altered distribution of aquaporin 5 and its C-terminal binding protein in the lacrimal glands of a mouse model for Sjogren's syndrome. Curr Eye Res 2008 ; 33 : 621-629.

10 Wilson SE, et al : Lacrimal gland HGF, KGF, and EGF mRNA levels increase after corneal epithelial wounding. Investigative Ophthalmol Vis Sci 1999 ; 40 : 2185-2190.

11 Paulsen F, et al : Human lacrimal gland mucins. Cell Tissue Res 2004 ; 316 : 167-177.

P.24 掲載の参考文献

1 Knop E, et al : The international workshop on meibomian gland dysfunction : report of the subcommittee on anatomy, physiology and pathophysiology of the meibomian gland. Invest Ophthalmol Vis Sci 2011 ; 52 : 1938-1978.

2 小幡博人ら : 剖検例72例におけるマイボーム腺の病理組織学的検討. 日本眼科学会雑誌 1994 ; 98 : 765-771.

P.30 掲載の参考文献

1 Bron AJ, et al : Functional aspects of the tear film lipid layer. Exp Eye Res 2004 ; 78 : 347-360.

2 Butovich IA : Lipidomics of human meibomian gland secretions : chemistry, biophysics, and physiological role of meibomian lipids. Prog Lipid Res 2011 ; 50 : 278-301.

3 Glasgow BJ, et al : Tear lipocalins bind a broad array of lipid ligands. Curr Eye Res 1995 ; 14 : 363-372.

4 Mochizuki H, et al : Turnover rate of tear film lipid layer determined by fluorophotometry. Br J Ophthalmol 2009 ; 93 : 1535-1538.

5 Nagyova B, et al : Components responsible for the surface tension of human tears. Curr Eye Res 1999 ; 19 : 4-11.

6 Borchman D, et al : Factors affecting evaporation rates of tear film components measured in vitro. Eye Contact Lens 2009 ; 35 : 32-37.

7 Herok GH, et al : The effect of Meibomian lipids and tear proteins on evaporation rate under controlled in vitro conditions. Curr Eye Res 2009 ; 34 : 589-597.

P.32 掲載の参考文献

1 Butovich IA : Lipidomics of human meibomian gland secretions : chemistry, biophysics, and physiological role of meibomian lipids. Prog Lipid Res 2011 ; 50 : 278-301.

2 Nagyova B, et al : Components responsible for the surface tension of human tears. Curr Eye Res 1999 ; 19 : 4-11.

3 Lam SM, et al : Meibum lipid composition in Asians with dry eye disease. PLoS ONE 2011 ; 6 : e24339.

4 Dean AW, et al : Mass spectrometric identification of phospholipids in human tears and tear lipocalin. Invest Ophthalmol Vis Sci 2012 ; 53 : 1773-1782.

P.34 掲載の参考文献

1 西田輝夫 : 角膜テキスト. 東京 : エルゼビア・ジャパン ; 2010. p.28-31.

2 Sariri R, et al : Tear proteins in health, disease, and contact lens wear. Biochemistry (Moscow) 2008 : 78 : 381-392.

P.38 掲載の参考文献

1 Glasgow BJ, et al : Focus on molecules : tear lipocalin. Exp Eye Res 2011 ; 92 : 242-243.

2 Gouveia SM, et al : Human tear viscosity : an interactive role for proteins and lipids. Biochim Biophys Acta 2005 ; 1753 : 155-163.

3 Selsted ME, et al : Isolation and purification of bactericides from human tears. Exp Eye Res 1982 ; 34 : 305-318.

4 Holzfeind P, et al : Expression of the gene for tear lipocalin/von Ebner's gland protein in human prostate. FEBS letters 1996 ; 395 : 95-98.

5 Glasgow BJ, et al : Tear lipocalins : potential lipid scavengers for the corneal surface. Invest Ophthalmol Vis Sci 1999 ; 40 : 3100-3107.

6 Gasymov OK, et al : Structural changes in human tear lipocalins associated with lipid binding. Biochim Biophys Acta 1998 ; 1386 : 145-156.

7 Nagyova B, et al : Components responsible for the surface tension of human tears. Curr Eye Res 1999 ; 19 : 4-11.

8 Caffery B, et al : Tear lipocalin and lysozyme in Sjogren and non-Sjogren dry eye. Optom Vis Sci 2008 ; 85 : 661-667.

9 Yamada M, et al : Decreased tear lipocalin concentration in patients with meibomian gland dysfunction. Br J Ophthalmol 2005 ; 89 : 803-805.

10 Glasson M, et al : Lipid, lipase and lipocalin differences between tolerant and intolerant contact lens wearers. Curr Eye Res 2002 ; 25 : 227-235.

P.41 掲載の参考文献

i Gipson IK, et al : Role of mucins in the function of the corneal and conjunctival epithelia. Int Rev Cytol 2003 ; 231 : 1-49.

ii Gipson IK, et al : Character of ocular surface mucins and their alteration in dry eye disease. Ocul Surf 2004 ; 2 : 131-148.

iii Argueso P, et al : MUC16 mucin is expressed by the human ocular surface epithelia and carries the H185 carbohydrate epitope. Invest Ophthalmol Vis Sci 2003 ; 44 : 2487-2495.

iv Hori Y, et al : Differential regulation of membrane-associated mucins in the human ocular surface epithelium. Invest Ophthalmol Vis Sci 2004 ; 45 : 114-122.

v Argueso P : Glycobiology of the ocular surface : mucins and lectins. Jpn J Ophthalmol 2013 ; 57 : 150-155.

P.46 掲載の参考文献

1 Thoft RA : Conjunctival transplantation. Arch Ophthalmol 1977 ; 95 : 1425-1427.

2 Thoft RA, et al : The X, Y, Z hypothesis of corneal epithelial maintenance. Invest Ophthalmol Vis Sci 1983 ; 10 : 1442-1443.

3 Itoh R, et al : Isolation and characterization of a Ca (2+) -activated chloride channel from human corneal epithelium. Curr Eye Res 2000 ; 21 : 918-925.

4 Cao L, et al : Chloride channels and transporters in human corneal epithelium. Exp Eye Res 2010 ; 90 : 771-779.

P.50 掲載の参考文献

1 Furuse M, et al : Claudin-1 and -2 : Novel integral membrane proteins localizing at tight junctions with no sequence similarity to occludin. J Cell Biol 1998 ; 141 : 1539-1550.

2 Tsukita S, et al : Multifunctional strands in tight junctions. Nat Rev Mol Cell Biol 2002 ; 2 : 285-293.

3 Furuse M, et al : Manner of interaction of heterogeneous claudin species within and between tight junction strands. J Cell Biol 1999 ; 147 : 891-903.

4 Ban Y, et al : Tight junction-related protein expression and distribution in human corneal epithelium. Exp Eye Res 2003 ; 76 : 663-669.

5 Yoshida Y, et al : Tight junction transmembrane protein claudin subtype expression and distribution in human corneal and conjunctival epithelium. Invest Ophthalmol Vis Sci 2009 ; 50 : 2103-2108.

3 涙液動態と病態とのかかわり

P.54 掲載の参考文献

1 Sterm ME, et al : The pathology of dry eye : the interaction between the ocular surface and lacrimal glands. Cornea 1998 ; 17 : 584-589.

2 Belmonte C, et al : Nerves and sensation from the eye surface. Ocul Surf 2004 ; 2 : 248-253.

3 Parra A, et al : Ocular surface wetness is regulated by TRPM8-dependent cold thermoreceptors of the cornea. Nat Med 2010 ; 16 : 1396-1399.

4 Belomonte C, et al : Cold thermoreceptors, unexpected plays in tear production and ocular dryness sensation. Invest Ophthalmol Vis Sci 2011 ; 52 : 3888-3892.

5 梶田雅義ら : 調節負荷とドライアイ関係の可能性について. 視覚の科学 2004 ; 25 : 40-45.

6 Arita R, et al : Caffeine increases tear volume depending on polymorphisms within the adenosine A2a receptor gene and cytochrome P450 1A2. Ophthalmology 2012 ; 119 : 972-978.

7 van Bijsterveld OP, et al : Central nervous system mechanisms in Sjogren's syndrome. Br J Ophthalmol 2003 ; 87 : 128-130.

P.56 掲載の参考文献

1 Yokoi N, et al : Tear meniscus changes during cotton thread and Schirmer testing. Invest Ophthalomol Vis Sci 2000 ; 41 : 3748-3753.

2 島崎潤 (ドライアイ研究会) : 2006年ドライアイ診断基準. あたらしい眼科 2007 ; 24 : 181-184.

3 McGill JI, et al : Normal tear protein profiles and age-related changes. Br J Ophthalmol 1984 ; 68 : 316-320.

4 Mathers WD, et al : Tear film changes associated with normal aging. Cornea 1996 ; 15 : 229-234.

5 Higashihara H, et al : Using synthesized onion lachrymatory factor to measure age-related decreases in reflex-tear secretion and ocular surface sensation. Jpn J Ophthalmol 2010 ; 54 : 215-220.

6 Sterm ME, et al : The pathology of dry eye : the interaction between the ocular surface and lacrimal glands. Cornea 1998 ; 17 : 584-589.

P.58 掲載の参考文献

1 Sack RA, et al : Diurnal tear cycle : Evidence for a nocturnal inflammatory constitutive tear fluid. Invest Ophthalmol Vis Sci 1992 ; 33 : 626-640.

2 Fukuda M, et al : Fibronectin in the tear film. Invest Ophthalmol Vis Sci 1996 ; 37 : 459-467.

3 Wilson G, et al : Cell content of tears following overnight wear of a contact lens. Curr Eye Res 1989 ; 8 : 329-335.

P.60 掲載の参考文献

1 横井則彦 : 涙液メニスカスの観察. ドライアイ診療PPP. 東京 : メジカルビュー社 ; 2002. p.25-27.

2 Holly FJ : Physical chemistry of the normal and disordered tear film. Trans Ophthalmol Soc UK 1985 ; 104 : 374-380.

3 McDonald JE, et al : Meniscus-induced thinning of tear films. Am J Ophthalmol 1971 ; 72 : 139-146.

4 Yokoi N, et al : Relationship between tear volume and tear meniscus curvature. Arch Ophthalmol 2004 ; 122 : 1265-1269.

5 鯖田秀樹ら : メニスカスの形成. 物理教育 1981 ; 29 : 241-245.

P.63 掲載の参考文献

1 McDonald JE, et al : Meniscus-induced thinning of tear films. Am J Ophthalmol 1971 ; 72 : 139-146.

2 横井則彦 : 涙液メニスカスの観察. ドライアイ診療PPP. 東京 : メジカルビュー社 ; 2002. p.25-27.

P.66 掲載の参考文献

1 Mochizuki H, et al : Turnover rate of tear-film lipid layer determined by fluorophotometry. Br J Ophthalmol 2009 ; 93 : 1535-1538.

2 高岡真帆ら : 眼表面における眼軟膏の滞留性と薬剤の徐放についての検討. 日本眼科学会雑誌 2004 ; 108 : 307-311.

3 Bron AJ, et al : Functional aspects of the tear film lipid layer. Exp Eye Res 2004 ; 78 : 347-360.

4 横井則彦ら : 涙液の液層と油層の密接な関係. 眼科 2010 ; 52 : 1763-1770.

5 Yokoi N, et al : Assessment of meibomian gland function in dry eye using meibometry. Arch Ophthalmol 1999 ; 117 : 723-729.

6 横井則彦ら : マイボーム腺の臨床的機能評価. あたらしい眼科 2011 ; 28 : 1073-1079.

P.69 掲載の参考文献

1 Mishima S, et al : Determination of tear volume and tear flow. Invest Ophthalmol Vis Sci 1966 ; 5 : 264-275.

2 Mochizuki H, et al : Fluorophotometric measurement of the precorneal residence time of topically applied hyaluronic acid. Br J Ophthalmol 2008 ; 92 : 108-111.

3 Tomlinson A, et al : Inputs and outputs of the lacrimal system : review of production and evaporative loss. Ocul Surf 2009 ; 7 : 186-198.

4 清水章代ら : フルオロフォトメトリーを用いた健常者の涙液量, 涙液turnover rateの測定. 日本眼科学会雑誌 1993 ; 97 : 1047-1052.

5 Nichols JJ, et al : Thinning rate of the precorneal and prelens tear films. Invest Ophthalmol Vis Sci 2005 ; 46 : 2353-2361.

P.72 掲載の参考文献

1 山本洋子ら : フルオロフォトメトリー法によるソフトコンタクトレンズ下の涙液交換の定量的評価. 日本コンタクトレンズ学会誌 1996 ; 38 : 86-89.

2 三島濟一 : コンタクトレンズ装用に関する角膜生理. 臨床眼科 1987 ; 41 : 235-241.

3 Kok JHC, et al : Fluorophotometric assessment of tear turnover under rigid contact lenses. Cornea 1992 ; 11 : 515-517.

4 河野明美ら : フルオロフォトメトリー法によるハードコンタクトレンズ下の涙液交換の定量的評価. 日本コンタクトレンズ学会誌 1994 ; 36 : 175-178.

5 河合正孝ら : コンタクトレンズ下の涙液交換率の測定. 日本眼科紀要 1998 ; 49 : 918-921.

6 Paugh JR, et al : Tear exchange under hydrogel contact lenses : methodological considerations. Invest Ophthalmol Vis Sci 2001 ; 42 : 2813-2820.

7 山田昌和ら : コンタクトレンズ下の酸素分圧の理論モデルによる検討. 日本コンタクトレンズ学会誌 1991 ; 33 : 205-210.

P.74 掲載の参考文献

1 Dartt DA, et al : Localization of nerves adjacent to goblet cells in rat conjunctiva. Curr Eye Res 1995 ; 14 : 993-1000.

2 Adams AD : The Morphology of human conjunctival mucus. Arch Ophthalmol 1979 ; 97 : 730-734.

P.76 掲載の参考文献

1 Hori Y, et al : Mucins and contact lens wear. Cornea 2006 ; 25 : 176-181.

2 Spurr-Michaud S, et al : Assays of mucins in human tear fluid. Exp Eye Res 2007 ; 84 : 939-950.

3 Blalock TD, et al : Release of membrane-associated mucins from ocular surface epithelia. Invest Ophthalmol Vis Sci 2008 ; 49 : 1864-1871.

P.78 掲載の参考文献

1 Tishler M, et al : Elevated tear interleukin-6 levels in patients with Sjogren syndrome. Ophthalmology 1998 ; 105 : 2327-2329.

2 Pflugfelder SC, et al : Altered cytokine balance in the tear fluid and conjunctiva of patients with Sjogren's syndrome keratoconjunctivits sicca. Curr Eye Res 1999 ; 19 : 201-211.

3 Danjo Y, et al : Alteration of mucin in human conjunctival epithelia in dry eye. Invest Ophthalmol Vis Sci 1998 ; 39 : 2602-2609.

4 Argueso P, et al : Decreased levels of the goblet cell mucin MUC5AC in tears of patients with Sjogren syndrome. Invest Ophthalmol Vis Sci 2002 ; 43 : 1004-1011.

P.80 掲載の参考文献

1 Tanioka H, et al : Investigation of the corneal filament in filamentary keratitis. Invest Ophthalmol Vis Sci 2009 ; 50 : 3696-3702.

P.83 掲載の参考文献

1 Butovich IA : The Meibomian puzzle : combining pieces together. Prog Retin Eye Res 2009 ; 28 : 483-498.

2 King-Smith PE, et al : The thickness of the tear film. Curr Eye Res 2004 ; 29 : 357-368.

3 横井則彦ら : 涙液の液層と油層の密接な関係. 特集マイボーム腺機能不全の考え方. 眼科 2010 ; 52 : 1763-1770.

4 Gipson IK : Distribution of mucins at the ocular surface. Exp Eye Res 2004 ; 78 : 379-388.

5 横井則彦ら : ドライアイのコア・メカニズム-涙液安定性仮説の考え方. あたらしい眼科 2012 ; 29 : 291-297.

6 島崎潤 (ドライアイ研究会) : 2006年ドライアイ診断基準. あたらしい眼科 2007 ; 24 : 181-184.

7 The definition and classification of dry eye disease : report of the Definition and Classification Subcommittee of the International Dry Eye WorkShop. Ocul Surf 2007 ; 5 : 75-92.

8 加藤弘明ら : ムチンの産生を増やす治療. あたらしい眼科 2013 ; 29 : 329-332.

9 横井則彦 : ドライアイの新しい治療戦略-眼表面の層別治療. 日本の眼科 2012 ; 83 : 1318-1322.

10 Yokoi N, et al : Tear-film-oriented diagnosis and therapy for dry eye. In : Yokoi N, editor. Dry Eye Syndrome : Basic and Clinical Perspectives. London : Future Medicine Ltd ; 2013. p.96-108.

P.87 掲載の参考文献

1 三島濟一 : 涙液分泌の生理と病理. 眼科臨床医報 1970 ; 64 : 89-99.

2 McDonald JE, et al : Meniscus-induced thinning of tear films. Am J Ophthalmol 1971 ; 72 : 139-146.

3 Reifler DM : Early descriptions of Horner's muscle and the lacrimal pump. Surv Ophthalmol 1996 ; 41 : 127-134.

4 Yokoi N, et al : Relationship between tear volume and tear meniscus curvature. Arch Ophthalmol 2004 ; 122 : 1265-1269.

5 Brown SI, et al : Hydrodynamics of Blinking. Arch Ophthalmol 1969 ; 82 : 541-547.

6 King-Smith PE, et al : The thickness of the tear film. Curr Eye Res 2004 ; 29 : 357-368.

7 Berger RE, et al : A surface tension gradient mechanism for driving the pre-corneal tear film after a blink. J Biomech 1974 ; 7 : 225-238.

8 Yokoi N, et al : Rheology of tear film lipid layer spread in normal and aqueous tear-deficient dry eyes. Invest Ophthalmol Vis Sci 2008 ; 49 : 5319-5324.

4 定義, 診断基準, 分類, 疫学

P.92 掲載の参考文献

1 世界ドライアイワークショップ2007年報告書. The Ocular Surface 2007 ; 5 : 1-126.

2 Lemp MA : Report of the National Eye Institute/Industry workshop on Clinical Trials in Dry Eyes. CLAO J 1995 ; 21 : 221-232.

P.96 掲載の参考文献

1 島崎潤 (ドライアイ研究会) : 2006年ドライアイ診断基準. あたらしい眼科 2007 ; 24 : 181-184.

2 Ishida R, et al : The application of a new continuous functional visual acuity measurement system in dry eye syndromes. Am J Ophthalmol 2005 ; 139 : 253-258.

3 Goto T, et al : A new method for tear film stability analysis using videokeratography. Am J Ophthalmol 2003 ; 135 : 607-612.

4 Koh S, et al : Effect of tear film break-up on higher-order aberrations measured with wavefront sensor. Am J Ophthalmol 2002 ; 134 : 115-117.

5 Manning FJ, et al : Patient tolerance and ocular surface staining characteristics of lissamine green versus rose bengal. Ophthalmology 1995 ; 102 : 1953-1957.

P.101 掲載の参考文献

1 The definition and classification of dry eye disease : report of the Definition and Classification Subcommittee of the International Dry Eye Workshop (2007). Ocul Surf 2007 ; 5 : 75-92.

P.103 掲載の参考文献

1 The definition and classification of dry eye disease : report of the Definition and Classification Subcommittee of the International Dry Eye WorkShop (2007). Ocul Surf 2007 ; 5 : 75-92.

2 横井則彦ら : ドライアイのコア・メカニズム-涙液安定性仮説の考え方. あたらしい眼科 2012 ; 29 : 291-297.

3 Behrens A, et al : Dysfunctional tear syndrome study group : Dysfunctional tear syndrome : a Delphi approach to treatment recommendations. Cornea 2006 ; 25 : 900-907.

P.107 掲載の参考文献

1 天野史郎 : マイボーム腺機能不全ワーキンググループ, マイボーム腺機能不全の定義と診断基準. あたらしい眼科 2010 ; 27 : 627-631.

2 Nichols KK, et al : The international workshop on meibomian gland dysfunction : executive summary. Invest Ophthalmol Vis Sci 2011 ; 52 : 1922-1929.

3 Shimazaki J, et al : Meibomian gland dysfunction in patients with Sjogren syndrome. Ophthalmology 1998 ; 105 : 1485-1488.

4 Arita R, et al : Non-contact infrared meibography to document age-related changes of the meibomian glands in a normal population. Ophthalmology 2008 ; 115 : 911-915.

5 Arita R, et al : A newly developed noninvasive and mobile pen-shaped meibography system. Cornea 2013 ; 32 : 242-247.

6 Matsumoto Y, et al : The application of in vivo laser confocal microscopy to the diagnosis and evaluation of meibomian gland dysfunction. Mol Vis 2008 ; 14 : 1263-1271.

P.111 掲載の参考文献

1 Vitali C, et al : Preliminary criteria for the classification of Sjogren's syndrome. Results of a prospective concerted action supported by the European Community. Arthritis Rheum 1993 ; 36 : 340-347.

2 Fujibayashi T : Revised diagnostic criteria for Sjogren's syndrome. Rheumatology (Oxford) 2000 ; 24 : 421-428.

3 van Bijsterveld OP : Diagnostic tests in the Sicca syndrome. Arch Ophthalmol 1969 ; 82 : 10-14.

P.114 掲載の参考文献

1 難病情報センター http://www.nanbyou.or.jp/entry/267

2 Sjogren's Syndrome Foundation http://www.sjogrens.org/

3 Zhang NZ, et al : Prevalence of primary Sjogren's syndrome in China. J Rheumatol 1995 ; 22 : 659-661.

4 Thomas E, et al : Sjogren's syndrome : a community-based study of prevalence and impact. Br J Rheumatol 1998 ; 37 : 1069-1076.

5 Vitali C, et al : Preliminary criteria for the classification of Sjogren's syndrome. Results of a prospective concerted action supported by the European Community. Arthritis Rheum 1993 ; 36 : 340-347.

6 Shiboski SC, et al : American College of Rheumatology classification criteria for Sjogren's syndrome : a data-driven, expert consensus approach in the Sjogren's International Collaborative Clinical Alliance cohort. Arthritis Care Res (Hoboken) 2012 ; 64 : 475-487.

7 Whitcher JP, et al : A simplified quantitative method for assessing keratoconjunctivitis sicca from the Sjogren's Syndrome International Registry. Am J Ophthalmol 2009 ; 149 : 405-415.

P.117 掲載の参考文献

1 The epidemiology of dry eye disease : report of the Epidemiology Subcommittee of the International Dry Eye WorkShop (2007). Ocul Surf 2007 ; 5 : 93-107.

2 Schaumberg DA, et al : Prevalence of dry eye syndrome among US women. Am J Ophthalmol 2003 ; 136 : 318-326.

3 Schiffman RM, et al : Reliability and validity of the Ocular Surface Disease Index. Arch Ophthalmol 2000 ; 118 : 615-621.

4 Schein OD, et al : Relation between signs and symptoms of dry eye in the elderly. A population-based perspective. Ophthalmology 1997 ; 104 : 1395-1401.

5 Rajagopalan K, et al : Comparing the discriminative validity of two generic and one diseasespecific health-related quality of life measures in a sample of patients with dry eye. Value Health 2005 ; 8 : 168-174.

6 Yu J, et al : The economic burden of dry eye disease in the United States : a decision tree analysis. Cornea 2011 ; 30 : 379-387.

7 Clegg JP, et al : The annual cost of dry eye syndrome in France, Germany, Italy, Spain, Sweden and the United Kingdom among patients managed by ophthalmologists. Ophthalmic Epidemiol 2006 ; 13 : 263-274.

8 Mizuno Y, et al : Annual direct cost of dry eye in Japan. Clin Ophthalmol 2012 ; 6 : 755-760.

9 Waduthantri S, et al : Cost of dry eye treatment in an Asian clinic setting. PLoS ONE 2012 ; 7 : e37711.

10 Reddy P, et al : The economic burden of dry eye : a conceptual framework and preliminary assessment. Cornea 2004 ; 23 : 751-761.

11 Ridder WH, et al : Impaired visual performance in patients with dry eye. Ocul Surf 2011 ; 9 : 42-55.

12 Yamada M, et al : Impact of dry eye on work productivity. Clinicoecon Outcomes Res 2012 ; 4 : 307-312.

P.122 掲載の参考文献

1 Uchino M, et al : Prevalence of dry eye disease among Japanese visual display terminal users. Ophthalmology 2008 ; 115 : 1982-1988.

2 Uchino M, et al : Japan Ministry of Health study on prevalence of dry eye disease among Japanese high school students. Am J Ophthalmol 2008 ; 146 : 925-929.

3 Uchino M, et al : Prevalence and risk factors of dry eye disease in Japan : Koumi study. Ophthalmology 2011 ; 118 : 2361-2367.

4 Schaumberg DA, et al : Prevalence of dry eye syndrome among US women. Am J Ophthalmol 2003 ; 136 : 318-326.

5 The epidemiology of dry eye disease : report of the Epidemiology Subcommittee of the International Dry Eye WorkShop (2007). Ocul Surf 2007 ; 5 : 93-107.

5 一般外来検査

P.126 掲載の参考文献

1 横井則彦 : ドライアイ診療の現状 (検査編) Frontiers in Dry Eye 2011 ; 6 : 90-98.

2 島崎潤 (ドライアイ研究会) : 2006年ドライアイ診断基準. あたらしい眼科 2007 ; 24 : 181-184.

3 横井則彦 : ドライアイの新しい治療戦略-眼表面の層別治療-. 日本の眼科 2012 ; 83 : 4-8.

4 横井則彦 : 生体染色検査アップデート. 臨床眼科 2012 ; 66 : 15-18.

P.131 掲載の参考文献

1 Nichols KK, et al : The lack of association between signs and symptoms in patients with dry eye disease. Cornea 2004 ; 23 : 762-770.

2 Begley CG, et al : The relationship between habitual patient-reported symptoms and clinical signs among patients with dry eye of varying severity. Invest Ophthalmol Vis Sci 2003 ; 44 : 4753-4761.

3 Chalmers RL, et al : The agreement between self-assessment and clinician assessment of dry eye severity. Cornea 2005 ; 24 : 804-810.

4 Miljanovic B, et al : Impact of dry eye syndrome on vision-related quality of life. Am J Ophthalmol 2007 ; 143 : 409-415.

5 Nelson JD, et al : A new look at dry eye disease and its treatment. Adv Ther 2000 ; 17 : 84-93.

6 Li M, et al : Anxiety and depression in patients with dry eye syndrome. Curr Eye Res 2011 ; 36 : 1-7.

7 Kim WK, et al : Association between depression and dry eye disease in an elderly population. Invest Ophthalmol Vis Sci 2011 ; 52 : 7954-7958.

8 Suzukamo Y, et al : Psychometric properties of the 25-item National Eye Institute Visual Function Questionnaire (NEI VFQ-25), Japanese version. Health Qual Life Outcomes 2005 ; 3 : 65-75.

9 Schiffman R, et al : Reliability and validity of the Ocular Surface Disease Index. Arch Ophthalmol 2000 ; 118 : 615-621.

10 Abetz L, et al : Development and validation of the impact of dry eye on everyday life (IDEEL) questionnaire, a patient-reported outcomes (PRO) measure for the assessment of the burden of dry eye on patients. Health Qual Life Outcomes 2011 ; 9 : 111-126.

11 Uchino Y, et al : Changes in dry eye diagnostic status following implementation of revised Japanese dry eye diagnostic criteria. Jpn Ophthalmol 2012 ; 56 : 8-13.

P.135 掲載の参考文献

1 横井則彦ら : 眼瞼下垂と角膜上皮障害. 眼科手術 2012 ; 3 : 387-389.

2 Goto T, et al : Cosmetic product migration onto the ocular surface : exacerbation of migration after eyedrop instillation. Cornea 2010 ; 29 : 400-403.

3 Adeela M, et al : Transport and interaction of cosmetic product material within the ocular surface : Beauty and the beastly symptoms of toxic tears. Contact lens & Anterior Eye 2012 ; 35 : 247-259.

P.138 掲載の参考文献

1 Mainstone JC, et al : Tear meniscus measurement in the diagnosis of dry eye. Curr Eye Res 1996 ; 15 : 653-661.

2 Mishima S, et al : Determination of tear volume and tear flow. Invest Ophthalmol 1966 ; 5 : 264-276.

3 Maurice DM : The dynamics and drainage of tears. Int Ophthalmol Clin 1973 ; 13 : 103-116.

4 Khanal S, et al : Nanoscale phase dynamics of the normal tear film. Nanomedicine 2010 ; 6 : 707-713.

5 鄭暁東 : 涙液の形態解析. あたらしい眼科 2013 ; 30 : 9-14.

6 Oguz H, et al : The height and radius of the tear meniscus and methods for examining theses parameters. Cornea 2000 ; 19 : 497-500.

7 Savini G, et al : Tear meniscus evaluation by optical coherence tomography. Ophthalmic Surg Lasers Imaging 2006 ; 37 : 112-118.

8 Yokoi N, et al : Reflective meniscometry : a new field of dry eye assessment. Cornea 2000 ; 19 : S37-43.

9 Fukuda R, et al : Tear meniscus evaluation by anterior segment swept-source optical coherence tomography. Am J Ophthalmol 2013 ; 155 : 620-624.

P.141 掲載の参考文献

1 Lamberts DW, et al : Schirmer test after topical anesthesia and the tear meniscus height in normal eyes. Arch Ophthalmol 1979 ; 97 : 1082-1085.

2 Mainstone JC, et al : Tear meniscus measurement in the diagnosis of dry eye. Curr Eye Res 1996 ; 15 : 653-661.

3 Tittler EH, et al : Between-grader repeatability of tear meniscus measurements using Fourierdomain OCT in patients with dry eye. Ophthalmic Surg Lasers Imaging 2011 ; 42 : 423-427.

4 Palakuru J, et al : Effect of blinking on tear dynamics. Invest Ophthalmol Vis Sci 2007 ; 48 : 3032-3037.

5 Shen M, et al : Upper and lower tear menisci in the diagnosis of dry eye. Invest Ophthalmol Vis Sci 2009 ; 50 : 2722-2726.

6 Tao A, et al : Upper and lower tear menisci after laser in situ keratomileusis. Eye Contact Lens 2010 ; 2 : 81-85.

7 Chen F, et al : Upper punctual occlusion versus lower punctual occlusion in dry eye. Invest Ophthalmol Vis Sci 2010 ; 51 : 5571-5577.

8 Chen Qi, et al : Tear menisci and ocular discomfort during daily contact lens wear in symptomatic wearers. Invest Ophthalmol Vis Sci 2011 ; 52 : 2175-2180.

9 Cui L, et al : Age-related changes in tear menisci imaged by optical coherence tomography. Optom Vis Sci 2011 ; 88 : 1214-1219.

10 Tao A, et al : Tear menisci after overnight contact lens wear. Optom Vis Sci 2011 ; 88 : 1433-1438.

11 Li J, et al : Clinical significance of tear menisci in dry eye. Eye Contact Lens 2012 ; 38 : 183-187.

12 Li M, et al : Effect of punctual occlusion on tear menisci in symptomatic contact lens wearers. Cornea 2012 ; 31 : 1014-1022.

13 Wang J, et al : Ultra-high resolution optical coherence tomography for monitoring tear meniscus volume in dry eye after topical cyclosporine treatment. Clin Ophthalmol 2012 ; 6 : 933-938.

14 Li M, et al : Daytime variations of tear osmolarity and tear meniscus volume. Eye Contact Lens 2012 ; 38 : 282-287.

15 Cui L, et al : Visualization of the precorneal tear film using ultrahigh resolution optical coherence tomography in dry eye. Eye Contact Lens 2012 ; 38 : 240-244.

16 Shen M, et al : Characterization of soft contact lens edge fitting using ultra-high resolution and ultra-long scan depth optical coherence tomography. Invest Ophthalmol Vis Sci 2011 ; 52 : 4091-4097.

17 Cui L, et al : Micrometer-scale contact lens movements imaged by ultrahigh-resolution optical coherence tomography. Am J Ophthalmol 2012 ; 153 : 275-283.

18 Chen Qi, et al : Ultrahigh-resolution measurement by optical coherence tomography of dynamic tear film changes on contact lenses. Invest Ophthalmol Vis Sci 2010 ; 51 : 1988-1993.

19 Choi D, et al : Fourier domain optical coherence tomography using optical demultiplexers imaging at 60,000,000 lines/s. Opt Lett 2008 ; 33 : 1318-1320.

P.147 掲載の参考文献

i 横井則彦 : ドライアイ治療の新しい治療戦略-眼表面の層別治療. 日本の眼科 2012 ; 83 : 1318-1322.

ii 山本雄士ら : Tear film breakup time (BUT) 短縮型ドライアイの臨床的特徴. 日本眼科学会雑誌 2012 ; 116 : 1137-1143.

P.150 掲載の参考文献

1 横井則彦 : 結膜・眼瞼疾患の生体染色. あたらしい眼科 2012 ; 29 : 1599-1605.

2 Freenstra RPG, et al : What is actually stained by rose bengal? Arch Ophthalmol 1992 ; 110 : 984-993.

3 味木幸ら : リサミングリーンB による角結膜上皮障害の観察. 日本眼科紀要 1999 ; 50 : 536-539.

4 宮田和典 : びまん性表層角膜炎の重症度の分類. 臨床眼科 1994 ; 48 : 183-188.

P.153 掲載の参考文献

1 大橋裕一 : 薬剤アレルギーの病態と治療 (細胞毒性によるもの). 眼科New Insight 第2巻, 点眼薬-常識と非常識. 東京 : メジカルビュー社 ; 1994. p.78-85.

2 大橋裕一ら : 角膜上皮の新しい病態-epithelial crack line. 臨床眼科 1992 ; 46 : 1539-1543.

3 Yokoi N, et al : Importance of conjunctival epithelial evaluation in the diagnostic differentiation of dry eye from drug-induced epithelial keratopathy. Adv Exp Med Biol 1998 ; 438 : 827-830.

4 Koh S, et al : Diagnosing dry eye using a blue-free barrier filter. Am J Ophthalmol 2003 ; 136 : 513-519.

P.157 掲載の参考文献

1 Koh S, et al : Diagnosing dry eye using a blue-free barrier filter. Am J Ophthalmol 2003 ; 136 : 513-519.

2 大野健治 : ブルーフリーフィルタを用いた検査. 坪田一男ら編. 眼科プラクティス 3 オキュラーサーフェスのすべて. 東京 : 文光堂 ; 2005.

3 Yokoi N, et al : Importance of conjunctival epithelial evaluation in the diagnostic differentiation of dry eye from drug-induced epithelial keratopathy. Adv Exp Med Biol 1998 ; 438 : 827-830.

P.161 掲載の参考文献

1 Schirmer O : Studien zur Physiologie und Pathologie der Tranenabsonderung und Tranenabfuhr. Albrecht von Graefes Arch Klin Exp Ophthalmol 1903 ; 56 : 197-291.

2 ドライアイ研究会 : 2006年ドライアイ診断基準. あたらしい眼科 2007 ; 24 : 181-184.

3 Tsubota K : The importance of the Schirmer test with nasal stimulation. Am J Ophthalmol 1991 ; 111 : 106-108.

P.163 掲載の参考文献

1 Bron AJ, et al : A solute gradient in the tear meniscus. I. A hypothesis to explain Marx's line. Ocul Surf 2011 ; 9 : 70-91.

2 天野史郎 : マイボーム腺機能不全の定義と診断基準. あたらしい眼科 2010 ; 27 : 627-631.

3 Hykin PJ, et al : Age-related morphological changes in lid margin and meibomian gland anatomy. Cornea 1992 ; 11 : 334-342.

4 Yamaguchi M, et al : Marx line : fluorescein staining line on the inner lid as indicator of meibomian gland function. Am J Ophthalmol 2006 ; 141 : 669-675.

5 Bron AJ, et al : Meibomian gland disease. Classification and grading of lid changes. Eye 1991 ; 5 : 395-411.

6 Mathers WD, et al : Meibomian gland dysfunction in chronic blepharitis. Cornea 1991 ; 10 : 277-285.

7 Shimazaki J, et al : Meibomian gland dysfunction in patients with Sjogren syndrome. Ophthalmology 1998 ; 105 : 1485-1488.

6 特殊検査

P.168 掲載の参考文献

1 Holly FJ : Physical chemistry of the normal and disordered tear film. Trans Ophthalmol Soc UK 1985 ; 104 : 374-380.

2 Mainstone JC, et al : Tear meniscus measurement in the diagnosis of dry eye. Curr Eye Res 1996 ; 15 : 653-661.

3 Yokoi N, et al : Reflective meniscometry : a non-invasive method to measure tear meniscus curvature. Br J Ophthalmol 1999 ; 83 : 92-97.

4 Yokoi N, et al : Reflective meniscometry : A new field of dry eye assessment. Cornea 2000 ; 19 : S37-S43.

5 Yokoi N, et al : Non-invasive methods of assessing the tear film. Exp Eye Res 2004 ; 78 : 399-407.

6 Oguz H, et al : The height and radius of the tear meniscus and methods for examining these parameters. Cornea 2000 ; 19 : 497-500.

7 Yokoi N, et al : Relationship between tear volume and tear meniscus curvature. Arch Ophthalmol 2004 ; 122 : 1265-1269.

P.171 掲載の参考文献

1 Mainstone JC, et al : Tear meniscus measurement in the diagnosis of dry eye. Curr Eye Res 1996 ; 15 : 653-661.

2 Oguz H, et al : The height and radius of the tear meniscus and methods for examining these parameters. Cornea 2000 ; 19 : 497-500.

3 Golding TR, et al : Relationship between tearmeniscus parameters and tear-film breakup. Cornea 1997 ; 16 : 649-661.

4 Yokoi N, et al : Relationship between tear volume and tear meniscus curvature. Arch Ophthalmol 2004 ; 122 : 1265-1269.

5 Dogru M, et al : Strip meniscometry : a new and simple method of tear meniscus evaluation. Invest Ophthalmol Vis Sci 2006 ; 47 : 1895-1901.

6 Ibrahim OM, et al : The efficacy, sensitivity, and specificity of strip meniscometry in conjunction with tear function tests in the assessment of tear meniscus. Invest Ophthalmol Vis Sci 2011 ; 52 : 2194-2198.

P.175 掲載の参考文献

1 島崎潤ら (ドライアイ研究会) : 2006年ドライアイ診断基準. あたらしい眼科 2007 ; 24 : 181-184.

2 三島濟一 : 角膜涙液の生理学. 眼科MOOK, No.15 角膜-最近の知見. 東京 : 金原出版 ; 1981. p.22-31.

3 小野眞史ら : 涙液のクリアランステスト. 臨床眼科 1991 ; 45 : 1143-1147.

4 楊浩勇ら : ドライアイに対する恒久的涙点閉鎖術. 日本眼科紀要 1995 ; 46 : 683-686.

P.178 掲載の参考文献

1 Luo L, et al : Experimental dry eye stimulates production of inflammatory cytokines and MMP-9 and activates MAPK signaling pathways on the ocular surface. Invest Ophthalmol Vis Sci 2004 ; 45 : 4293-4301.

2 Uchino Y, et al : Oxidative stress induced inflammation initiates functional decline of tear production. PLoS ONE 2012 ; 7 : e45805.

3 The definition and classification of dry eye disease : report of the Definition and Classification Subcommittee of the International Dry Eye WorkShop (2007). Ocul Surf 2007 ; 5 : 75-92.

4 小野眞史 : 涙液クリアランスから見たドライアイ. Frontiers in Dry Eye 2007 ; 2 : 55-58.

P.182 掲載の参考文献

1 King-Smith PE, et al : Three interferometric methods for measuring the thickness of layers of the tear film. Optom Vis Sci 1999 ; 76 : 19-32.

2 Yokoi N, et al : Correlation of tear lipid layer interference patterns with the diagnosis and severity of dry eye. Am J Ophthalmol 1996 ; 122 : 818-824.

3 Goto E, et al : Computer-synthesis of an interference color chart of human tear lipid layer, by a colorimetric approach. Invest Ophthalmol Vis Sci 2003 ; 44 : 4693-4697.

4 Goto E, et al : Kinetic analysis of tear interference images in aqueous tear deficiency dry eye before and after punctal occlusion. Invest Ophthalmol Vis Sci 2003 ; 44 : 1897-1905.

5 Yokoi N, et al : Rheology of tear film lipid layer spread in normal and aqueous tear-deficient dry eyes. Invest Ophthalmol Vis Sci 2008 ; 49 : 5319-5324.

6 Hosaka E, et al : Interferometry in the evaluation of precorneal tear film thickness in dry eye. Am J Ophthalmol 2011 ; 151 : 18-23.

7 Uchida A, et al : Noninvasive interference tear meniscometry in dry eye patients with Sjogren syndrome. Am J Ophthalmol 2007 ; 144 : 232-237.

8 Maruyama K, et al : Effect of environmental conditions on tear dynamics in soft contact lens wearers. Invest Ophthalmol Vis Sci 2004 ; 45 : 2563-2568.

9 Goto E, et al : Successful tear lipid layer treatment for refractory dry eye in office workers by low-dose lipid application on the full-length eyelid margin. Am J Ophthalmol 2006 ; 142 : 264-270.

P.188 掲載の参考文献

1 Tapie R : Biomicroscopial study of Meibomian glands (in French). Ann Ocul 1977 ; 210 : 637-648.

2 Arita R, et al : Noncontact infrared meibography to document age-related changes of the meibomian glands in a normal population. Ophthalmology 2008 ; 115 : 911-915.

3 Arita R, et al : A newly developed noninvasive and mobile pen-shaped meibography system. Cornea 2012 ; 32 : 242-247.

4 Pult H, et al : Relation between upper and lower lids' meibomian gland morphology, tear film, and dry eye. Optom Vis Sci 2012 ; 89 : E310-315.

5 Eom Y, et al : Correlation between quantitative measurements of tear film lipid layer thickness and meibomian gland loss in patients with obstructive meibomian gland dysfunction and normal controls. Am J Ophthalmol 2013 ; 155 : 1104-1110.

P.192 掲載の参考文献

1 Arita R, et al : Noncontact infrared meibography to document age-related changes of the meibomian glands in a normal population. Ophthalmology 2008 ; 115 ; 911-915.

2 Arita R, et al : Proposed diagnostic criteria for obstructive meibomian gland dysfunction. Ophthalmology 2009 ; 116 ; 2058-2063.

3 Arita R, et al : Proposed diagnostic criteria for seborrheic meibomian gland dysfunction. Cornea 2010 ; 29 : 980-984.

4 Arita R, et al : Contact lens wear is associated with decrease of meibomian glands. Ophthalmology 2009 ; 116 ; 379-384.

5 Arita R, et al : Meibomian gland duct distortion in patients with perennial allergic conjunctivitis. Cornea 2010 ; 29 ; 858-860.

6 Arita R, et al : Comparison of the long-term effects of various topical antiglaucoma medications on meibomian glands. Cornea 2012 ; 31 : 1229-1234.

7 Arita R, et al : Effects of long-term topical anti-glaucoma medications on meibomian glands. Graefes Arch Clin Exp Ophthalmol 2012 ; 250 : 1181-1185.

8 Arita R, et al : Decreased surface temperature of tarsal conjunctiva decreases in patients with meibomian gland dysfunction. JAMA Ophthalmol 2013 ; 131 : 818-819.

P.196 掲載の参考文献

1 Wakamatsu TH, et al : Conjunctival in vivo confocal scanning laser microscopy in patients with Sjogren syndrome. Invest Ophthalmol Vis Sci 2010 ; 51 : 144-150.

2 Kojima T, et al : The application of in vivo laser scanning confocal microscopy as a tool of conjunctival in vivo cytology in the diagnosis of dry eye ocular surface disease. Mol Vis 2010 ; 16 : 2457-2464.

3 Sato EA, et al : The lacrimal gland in Sjogren's syndrome. Ophthalmology 2010 ; 117 : 1055.

4 Kojima T, et al : In vivo evaluation of superior limbic keratoconjunctivitis using laser scanning confocal microscopy and conjunctival impression cytology.Invest Ophthalmol Vis Sci 2010 ; 51 : 3986-3992.

P.203 掲載の参考文献

1 Stave J, et al : Modified Heidelberg Retinal Tomograph HRT. Initial results of in vivo presentation of corneal structures. Ophthalmologe 2002 ; 99 : 276-280.

2 小幡博人ら : 剖検例72例におけるマイボーム腺の病理組織学的検討. 日本眼科学会雑誌 1994 ; 98 : 765-777.

3 Arita R, et al : Proposed diagnostic criteria for obstructive meibomian gland dysfunction. Ophthalmology 2009 ; 116 : 2058-2063.

4 Matsumoto Y, et al : The application of in vivo laser confocal microscopy to the diagnosis and evaluation of meibomian gland dysfunction. Mol Vis 2008 ; 14 : 1263-1271.

P.206 掲載の参考文献

1 Lemp MA : Report of the National Eye Institute/Industry workshop on Clinical Trials in Dry Eyes. CLAO J 1995 ; 21 : 221-232.

2 Rolando M, et al : Increased tear evaporation in eyes with keratoconjunctivitis sicca. Arch Ophthalmol 1983 ; 101 : 557-558.

3 Rolando M, et al : Tear evaporimeter for measuring water evaporation rate from the tear film under controlled conditions in humans. Exp Eye Res 1983 ; 36 : 25-33.

4 Mathers WD, et al : Tear flow and evaporation in patients with and without dry eye. Ophthalmology 1996 ; 103 : 664-669.

5 Mathers WD, et al : Ocular water evaporation and the dry eye. A new measuring device. Cornea 1993 ; 12 : 335-340.

6 Hamano H, et al : Application of an evaporimeter to the field of ophthalmology. J Jpn Contact Lens Soc 1980 ; 22 : 101-107.

7 Shimazaki J, et al : Meibomian gland dysfunction in patients with Sjogren syndrome. Ophthalmology 1998 ; 105 : 1485-1488.

8 Tsubota K, et al : Tear evaporation from the ocular surface. Invest Ophthalmol Vis Sci 1992 ; 33 : 2942-2950.

9 Goto E, et al : Tear evaporation dynamics in normal subjects and subjects with obstructive meibomian gland dysfunction. Invest Ophthalmol Vis Sci 2003 ; 44 : 533-539.

10 Goto E, et al : Tear evaporation rates in Sjogren syndrome and non-Sjogren dry eye patients. Am J Ophthalmol 2007 ; 144 ; 81-85.

11 Mathers WD : Ocular evaporation in meibomian gland dysfunction and dry eye. Ophthalmology 1993 ; 100 : 347-351.

12 Shimazaki J, et al : Ocular surface changes and discomfort in patients with meibomian gland dysfunction. Arch Ophthalmol 1995 ; 113 : 1266-1270.

P.209 掲載の参考文献

1 Gilbard JP : Tear film osmolarity and keratoconjunctivitis sicca. CLAO J 1985 ; 11 : 243-250.

2 Tomlinson A, et al : Tear film osmolarity : determination of a referent for dry eye diagnosis. Invest Ophthalmol Vis Sci 2006 ; 47 : 4309-4315.

3 Versura P, et al : Performance of tear osmolarity compared to previous diagnostic tests for dry eye diseases. Curr Eye Res 2010 ; 35 : 553-564.

P.212 掲載の参考文献

1 Ishida R, et al : The application of a new continuous functional visual acuity measurement system in dry eye syndromes. Am J Opthalmol 2005 ; 139 : 253-258.

2 Kaido M, et al : Concept of functional visual acuity and its applications. Cornea 2007 ; 26 : S29-35. Review.

3 Kaido M, et al : The relation of functional visual acuity measurement methodology to tear functios and ocular surface status. Jpn J Ophthalmol 2011 ; 55 : 451-459.

4 Kaido M, et al : Corneal fluorescein staining correlates with visual function in dry eye patients. Invest Ophthalmol Vis Sci 2011 ; 52 : 9516-9522.

P.215 掲載の参考文献

1 Goto T, et al : A new method for tear film stability analysis using videokeratography. Am J Ophthalmol 2003 ; 135 : 607-612.

2 Kojima T, et al : A new noninvasive tear stability analysis system for the assessment of dry eyes. Invest Ophthalmol Vis Sci 2004 ; 45 : 1369-1374.

3 Goto T, et al : Evaluation of the tear film stability after laser in situ keratomileusis using tear film stability analysis system. Am J Ophthalmol 2004 ; 137 : 116-120.

4 川崎史朗ら : 涙液層安定性解析装置によるマレイン酸チモロールゲル化剤点眼後の涙液層への影響の検討. 日本眼科学会雑誌 2008 ; 112 : 539-544.

5 山口昌彦ら : Tear Stability Analysis Systemを用いたヒアルロン酸点眼液の涙液安定性に対する持続効果の検討. 日本眼科学会雑誌 2011 ; 115 : 134-141.

P.218 掲載の参考文献

1 Koh S, et al : Effect of tear film break-up on higher-order aberrations measured with wavefront sensor. Am J Ophthalmol 2002 ; 134 : 115-117.

2 Koh S, et al : Serial measurements of higher-order aberrations after blinking in normal subjects. Invest Ophthalmol Vis Sci 2006 ; 47 : 3318-3324.

P.221 掲載の参考文献

1 Koh S, et al : Effects of suppression of blinking on quality of vision in borderline cases of evaporative dry eye. Cornea 2008 ; 27 : 275-278.

2 Koh S, et al : Serial measurements of higher-order aberrations after blinking in patients with dry eye. Invest Ophthalmol Vis Sci 2008 ; 49 : 133-138.

3 Koh S, et al : Paradoxical increase of visual impairment with punctal occlusion in a patient with mild dry eye. J Cataract Refract Surg 2006 ; 32 : 689-691.

7 コア・メカニズムの考えかたと治療

P.226 掲載の参考文献

1 Lemp MA : Report of the National Eye Institute/Industry Workshop on Clinical Trials in Dry Eyes. CLAO J 1995 ; 21 : 221-232.

2 島崎潤 : ドライアイの定義と診断基準. 眼科 1995 ; 37 : 765-770.

3 Dry Eye WorkShop. Ocular Surf 2007 ; 5 : 10-126.

4 島崎潤 (ドライアイ研究会) : 2006年ドライアイ診断基準. あたらしい眼科 2007 ; 24 : 181-184.

5 横井則彦 : ドライアイのあたらしい治療戦略-眼表面の層別治療. 日本の眼科 2013 ; 83 : 1318-1322.

6 横井則彦ら : ドライアイのコア・メカニズム-涙液安定性仮説の考え方. あたらしい眼科 2012 ; 29 : 291-297.

P.231 掲載の参考文献

1 Sand BB, et al : Sodium hyaluronate in the treatment of keratoconjunctivitis sicca. A double masked clinical trial. Acta Ophthalmol 1989 ; 67 : 181-183.

2 Watanabe H : Significance of mucin on the ocular surface. Cornea 2002 ; 21 : S17-22.

P.233 掲載の参考文献

1 島崎潤 (ドライアイ研究会) : 2006年ドライアイ診断基準. あたらしい眼科 2007 ; 24 : 181-184.

2 The 2007 International Dry Eye WorkShop : The definition and classification of dry eye disease : report of the Definition and Classification Subcommittee of the International Dry Eye WorkShop. Ocul Surf 2007 ; 5 : 75-92.

3 Lemp MA, et al : Tear osmolarity in the diagnosis and management of dry eye disease. Am J Ophthalmol 2011 ; 151 : 792-798.

4 Luo L, et al : Experimental dry eye stimulates production of inflammatory cytokines and MMP-9 and activates MAPK signaling pathways on the ocular surface. Invest Ophthalmol Vis Sci 2004 ; 45 : 4293-4301.

5 Stern ME, et al : Conjunctival T-cell subpopulations in Sjogren's and non-Sjogren's patients with dry eye. Invest Ophthalmol Vis Sci 2002 ; 43 : 2609-2614.

6 Niederkorn JY, et al : Desiccating stress induces T cell-mediated Sjogren's syndrome-like lacrimal keratoconjunctivitis. J Immunol 2006 ; 176 : 3950-3957.

7 Schaumburg CS, et al : Ocular surface APCs are necessary for autoreactive T cell-mediated experimental autoimmune lacrimal keratoconjunctivitis. J Immunol 2011 ; 187 : 3653-3662.

8 De Paiva CS, et al : IL-17 disrupts corneal barrier following desiccating stress. Mucosal Immunol 2009 ; 2 : 243-253.

9 Chauhan SK, et al : Autoimmunity in dry eye is due to resistance of Th17 to Treg suppression. J Immunol 2009 ; 182 : 1247-1252.

10 Stevenson W, et al : Dry eye disease : an immune-mediated ocular surface disorder. Arch Ophthalmol 2012 ; 130 : 90-100.

P.238 掲載の参考文献

1 Pflugfelder SC : Antiinflammatory therapy for dry eye. Am J Ophthalmol 2004 ; 137 : 337-342.

2 Paiva CS, et al : Rationale for anti-inflammatory therapy in dry eye syndrome. Arq Bras Oftalmol 2008 ; 71 : 89-95.

3 Kymionis GD, et al : Treatment of chronic dry eye : focus on cyclosporine. Clinical Ophthalmology 2008 ; 4 : 829-836.

4 Stevenson D, et al : Efficacy and safety of cyclosporine A ophthalmic emulsion in the treatment of moderate-to-severe dry eye disease : a dose-ranging, randomized trial. The Cyclosporine A Phase 2 Study Group. Ophthalmology 2000 ; 107 : 967-974.

5 Sall K, et al : Two multicenter, randomized studies of the efficacy and safety of cyclosporine ophthalmic emulsion in moderate to severe dry eye disease. CsA Phase 3 Study Group. Ophthalmology 2000 ; 107 : 631-639.

6 Barber LD, et al : Phase III safety evaluation of cyclosporine 0.1 % ophthalmic emulsion administered twice daily to dry eye disease patients for up to 3 years. Ophthalmology 2005 ; 112 : 1790-1794.

7 Chen M, et al : A comparison of cyclosporine 0.05% ophthalmic emulsion versus vehicle in Chinese patients with moderate to severe dry eye disease : an eight-week, multicenter, randomized, double-blind, parallel-group trial. J Ocul Pharmacol Ther 2010 ; 26 : 361-366.

8 Byun YS, et al : Cyclosporine 0.05% ophthalmic emulsion for dry eye in Korea : a prospective, multicenter, open-label, surveillance study. Korean J Ophthalmol 2011 ; 25 : 369-374.

P.241 掲載の参考文献

1 The 2007 International Dry Eye WorkShop : The definition and classification of dry eye disease : report of the Definition and Classification Subcommittee of the International Dry Eye WorkShop (2007). Ocul Surf 2007 ; 5 : 75-92.

2 Avunduk AM, et al : The comparison of efficacies of topical corticosteroids and nonsteroidal anti-inflammatory drops on dry eye patients : a clinical and immunocytochemical study. Am J Ophthalmol 2003 ; 136 : 593-602.

P.243 掲載の参考文献

1 大竹雄一郎ら : 点眼液中の防腐剤による角膜上皮障害について. あたらしい眼科 1991 ; 8 : 1559-1603.

2 Sall K : Two multicenter, randomized studies of the efficacy and safety of cyclosporine ophthalmic emulsion in moderate to severe dry eye disease. CsA Phase 3 Study Group. Ophthalmology 2000 ; 107 : 631-639.

3 七條優子ら : 正常ウサギにおけるジクアホソルナトリウムの涙液分泌促進作用. あたらしい眼科 2011 ; 28 : 1029-1033.

4 七條優子ら : ジクアホソルナトリウムのウサギ結膜組織からのMUC5ACの分泌促進作用. あたらしい眼科 2011 ; 28 : 261-265.

5 有田玲子 : 油成分を増やすドライアイ治療. あたらしい眼科 2012 ; 29 : 333-337.

6 山口昌彦ら : 3 % ジクアホソルナトリウム点眼液のドライアイを対象としたオープンラベルによる投与試験. あたらしい眼科 2012 ; 29 : 527-535.

7 Urashima H, et al : Rebamipide increases the amount of mucin-like substances on the conjunctiva and cornea in the N-acetylcystein-treated in vivo model. Cornea 2004 ; 23 : 613-619.

8 Urashima H, et al : Rebamipide increases mucin-like substance contents and periodic acid Schiff reagent-positive cells density in normal rabbits. J Ocul Pharmacol Ther 2012 : 28 : 264-270.

9 Kinoshita S, et al : A randomized, multicenter phase 3 study comparing 2 % rebamipide (OPC-12759) with 0.1 % sodium hyaluronate in the treatment of dry eye. Ophthalmology 2002 ; 120 : 1158-1165.

10 加藤弘明 : ムチンの産生を増やす治療. あたらしい眼科 2012 ; 29 : 329-332.

11 横井則彦 : ドライアイの新しい治療戦略-眼表面の層別治療-. 日本の眼科 2012 ; 88 : 1318-1322.

12 山本雄士ら : Tear film breakup time (BUT) 短縮型ドライアイの臨床的特徴. 日本眼科学会雑誌 2012 ; 116 : 1137-1143.

13 七條優子ら : 培養ヒト角膜上皮細胞におけるジクアホソルナトリウムの膜結合型ムチン遺伝子の発現促進作用. あたらしい眼科 2011 ; 28 : 425-429.

14 Kojima T, et al : The effect of autologous serum eyedrops in the treatment of severe dry eye disease : A prospective randomized case-control study. American Journal of Ophthalmology 2005 ; 139 : 242-246.

15 Goto E, et al : Low-concentration homogenized castor oil eye drops for noninflamed obstructive meibomian gland dysfunction. Ophthalmology 2002 ; 109 : 2030-2035.

P.248 掲載の参考文献

1 Tsubota K, et al : Serum application for the treatment of ocular surface disorders. Int'l Ophthal Clin 2000 ; 40 : 113-122.

2 Tsubota K, et al : Treatment of dry eye by autologous serum application in Sjogren's syndrome. Br J Ophthalmol 1999 ; 83 : 390-395.

3 Tsubota K, et al : Treatment of persistent corneal epithelial defect by autologous serum application. Ophthalmology 1999 ; 106 : 1984-1989.

4 Ogawa Y, et al : Autologous serum eye drops for the treatment of severe dry eye in patients with chronic graft-versus-host disease. Bone Marrow Transplant 2003 ; 31 : 579-583.

5 Noda-Tsuruya T, et al : Autologous serum eye drops for dry eye after LASIK. J Refract Surg 2006 ; 22 : 61-66.

6 Goto E, et al : Treatment of superior limbic keratoconjunctivitis by application of autologous serum. Cornea 2001 ; 20 : 807-810.

7 Matsumoto Y, et al : Autologous serum application in the treatment of neurotrophic keratopathy. Ophthalmology 2004 ; 111 : 1115-1120.

8 Kojima T, et al : The effect of autologous serum eye drops in the treatment of severe dry eye disease : a prospective randomized case-control study. Am J Ophthalmol 2005 ; 139 : 242-246.

P.251 掲載の参考文献

1 Hosoya K, et al : Nucleotide stimulation of Cl- secretion in the pigmented rabbit conjunctiva. J Pharmacol Exp Ther 1999 ; 291 : 53-59.

2 Li Y, et al : Rabbit conjunctival epithelium transports fluid, and P2Y2 receptor agonists stimulate Cl-and fluid secretion. Am J Physiol Cell Physiol 2001 ; 281 : C595-602.

3 Jumblatt JE, et al : Regulation of ocular mucin secretion by P2Y2 nucleotide receptors in rabbit and human conjunctiva. Exp Eye Res 1998 ; 67 : 341-346.

4 Murakami T, et al : Diquafosol elicits increases in net Cl- transport through P2Y2 receptor stimulation in rabbit conjunctiva. Ophthalmic Res 2004 ; 36 : 89-93.

5 Matsumoto Y, et al : Efficacy and safety of diquafosol ophthalmic solution in patients with dry eye syndrome : a Japanese phase 2 clinical trial. Ophthalmology 2012 ; 119 : 1954-1960.

6 Takamura E, et al : Diquafosol Ophthalmic Solution Phase 3 Study Group. A randomized, double-masked comparison study of diquafosol versus sodium hyaluronate ophthalmic solutions in dry eye patients. Br J Ophthalmol 2012 ; 96 : 1310-1315.

7 Shimazaki-Den S, et al : Effects of diquafosol sodium eye drops on tear film stability in short BUT type of dry eye. Cornea 2013 ; 32 : 1120-1125.

8 七條優子ら : 培養ヒト角膜上皮細胞におけるジクアホソルナトリウムの膜結合型ムチン遺伝子の発現促進作用. あたらしい眼科 2011 ; 28 : 425-429.

P.254 掲載の参考文献

1 Kimura K, et al : Protection of human corneal epithelial cells from TNF-α-induced disruption of barrier function by rebamipide. Invest Ophthalmol Vis Sci 2013 ; 54 : 2572-2760.

2 Tanaka H, et al : Rebamipide increases barrier function and attenuates TNFα-induced barrier disruption and cytokine expression in human corneal epithelial cells. Br J Ophthalmol 2013 ; 97 : 912-916.

3 Urashima H, et al : Rebamipide increases mucin-like substance contents and periodic acid Schiff reagent-positive cells density in normal rabbits. J Ocul Pharmacol Ther 2012 ; 28 : 264-270.

4 Rios JD, et al : Effect of OPC-12759 on EGF receptor activation, p44/p42 MAPK activity, and secretion in conjunctival goblet cells. Exp Eye Res 2008 ; 86 : 629-636.

5 Ueta M, et al : Rebamipide Suppresses PolyI : C-stimulated cytokine production in human conjunctival epithelial cells. J Ocul Pharmacol Ther 2013 May 10. [Epub ahead of print]

6 Urashima H, et al : Rebamipide increases the amount of mucin-like substances on the conjunctiva and cornea in the N-acetylcysteine-treated in vivo model. Corena 2004 ; 23 : 613-619.

7 中島英雄ら : ウサギ眼表面ムチン被覆障害モデルにおける角結膜上皮障害に対するレバミピド点眼液の効果. あたらしい眼科 2012 ; 29 : 1147-1151.

8 Kinoshita S, et al : Rebamipide ophthalmic suspension phase 3 study group. A randomized, multicenter phase 3 study comparing 2 % rebamipide (OPC-12759) with 0.1% sodium hyaluronate in the treatment of dry eye. Ophthalmology 2013 ; 120 : 1158-1165.

P.256 掲載の参考文献

1 Lemp MA : Report of the National Eye Institute/Industry workshop on Clinical Trials in Dry Eyes. CLAO J 1995 ; 21 : 221-232.

2 横井則彦 : 蒸発亢進型ドライアイの病態, 原因, およびその治療. 日本の眼科 2007 ; 78 : 721-726.

3 Tsubota K, et al : Spectacle side panels and moist inserts for the treatment of dry-eye patients. Cornea 1994 ; 13 : 197-201.

4 GOODS Introduction目の乾燥対策商品紹介. Frontiers in Dry Eye 2012 ; 7 : 92-93.

P.258 掲載の参考文献

1 Bressler NM, et al : Potential public health impact of Age-Related Eye Disease Study results : AREDS report no.11. Arch Ophthalmol 2003 ; 121 : 1621-1624.

2 Tsubota K, et al : Serum application for the treatment of ocular surface disorders. Int Ophthalmol Clin 2000 ; 40 : 113-122.

3 Nakamura Y, et al : Inflammatory cytokines in normal human tears. Curr Eye Res 1998 ; 17 : 673-676.

P.261 掲載の参考文献

1 Dyerberg J, et al : Eicosapentaenoic acid and prevention of thrombosis and atherosclerosis? Lancet 1978 ; 2 : 117-119.

2 Dyerberg J, et al : Fatty acid composition of the plasma lipids in Greenland Eskimos. Am J clin nutr 1975 ; 28 : 958-966.

3 Covington, MB : Omega-3 fatty acids. Am Fam Physician 2004 ; 70 : 133-140.

4 Yokoyama M, et al : Effects of eicosapentaenoic acid on major coronary events in hypercholesterolaemic patients (JELIS) : a randomised open-label, blinded endpoint analysis. Lancet 2007 ; 369 : 1090-1098.

5 Miljanovic B, et al : Relation between dietary n-3 and n-6 fatty acids and clinically diagnosed dry eye syndrome in women. Am J Clin Nutr 2005 ; 82 : 887-893.

6 Wojtowicz JC, et al : Pilot, prospective, randomized, double-masked, placebo-controlled clinical trial of an omega-3 supplement for dry eye. Cornea 2011 ; 30 : 308-314.

7 Brignole-Baudouin F, et al : A multicentre, double-masked, randomized, controlled trial assessing the effect of oral supplementation of omega-3 and omega-6 fatty acids on a conjunctival inflammatory marker in dry eye patients. Acta Ophthalmol 2011 ; 89 : e591-597.

8 Jarvinen RL, et al : Effects of oral sea buckthorn oil on tear film fatty acids in individuals with dry eye. Cornea 2011 ; 30 : 1013-1019.

8 上流のリスクとその治療 / 涙液減少

P.269 掲載の参考文献

1 Norn MS : Micropunctate fluorescein vital staining of the cornea. Acta Ophthalmol 1970 ; 48 : 108-118.

2 Feenstra RP, et al : Comparison of fluorescein and rose bengal staining. Ophthalmology 1992 ; 99 : 605-617.

3 Tabery HM : Dual appearance of fluorescein staining in vivo of diseased human corneal epithelium : a non-contact photomicrographic study. Br J Ophthalmol 1992 ; 76 : 43-44.

4 Bergmanson JP : Histopathological analysis of the corneal epithelium after contact lens wear. J Am Optom Assoc 1987 ; 58 : 812-818.

5 Fraunfelder FT, et al : Corneal mucus plaques. Am J Ophthalmol 1977 ; 83 : 191-197.

6 Tanioka H, et al : Investigation of the corneal filament in filamentary keratitis. Invest Ophthalmol Vis Sci 2009 ; 50 : 3696-3702.

P.272 掲載の参考文献

1 Fox RI, et al : Sjogren's syndrome, proposed criteria for classification. Arthritis Rheum 1986 : 29 : 577-585.

2 Tsubota K, et al : Defective cellular trafficking of lacrimal gland aquaporin-5 in Sjogren's syndrome. Lancet 2001 ; 357 : 688-689.

3 柏崎禎夫ら : シェーグレン症候群の口腔乾燥症状に対するSNI-2011の有効性および安全性に関する容量漸増法による検討-SNI-2011 前記第II相試験. 診療と新薬 2001 : 38 : 313-332.

4 Johnson JT, et al : Oral pilocarpine for post-irradiation xerostomia in patients with head and neck cancer. N Engl J Med 1993 ; 329 : 390-395.

5 Ono M, et al : Therapeutic effect of cevimeline on dry eye in patients with Sjogren's syndrome : a randomized, double-blind clinical study. Am J Ophthalmol 2004 ; 138 : 6-17.

6 Aragona P, et al : Conjunctival epithelium improvement after systemic pilocarpine in patients with Sjogren's syndrome. Br J Ophthalmol 2006 ; 90 : 166-170.

P.275 掲載の参考文献

1 Balaram M, et al : Efficacy and tolerability outcomes after punctal occlusion with silicon plugs in dry eye syndrome. Am J Ophthalmol 2001 ; 131 : 30-36.

2 西井正和ら : 新しい涙点プラグ (フレックスプラグ(R)) の脱落についての検討. 日本眼科学会雑誌 2004 ; 108 : 139-143.

3 Parikh NB, et al : Retention rate of silicone punctal plugs placed by residents in a general clinic setting. Ophthal Plast Recontr Surg 2010 ; 26 : 400-402.

4 Horwath-Winter J, et al : Long-term retention rates and complications of silicone punctal plugs in dry eye. Am J Ophthalmol 2007 ; 144 : 441-444.

5 Kaido M, et al : Efficacy of punctum plug treatment in short break-up time dry eye. Optom Vis Sci 2008 ; 85 : 758-763.

6 Chen F, et al : Upper punctal occlusion versus lower punctal occlusion in dry eye. Invest Ophthalmol Vis Sci 2010 ; 52 : 5571-5577.

7 Kaido M, et al : Visual function changes after punctal occlusion with the treatments of short BUT type of dry eye. Cornea 2012 ; 31 : 1009-1013.

P.281 掲載の参考文献

1 濱野孝 : 液状涙道プラグ「キープティア」. 眼科手術 2008 ; 21 : 475-478.

2 濱野孝ら : アテロコラーゲンによる涙道閉鎖-涙液減少症69例における臨床試験. 臨床眼科 2004 ; 58 : 2289-2294.

3 中野聡子ら : ドライアイに対するアテロコラーゲン涙点プラグ (キープティア(R)) の治療効果. 臨床眼科 2011 ; 65 : 231-235.

4 Hirai K, et al : Clinical evaluation of the therapeutic effects of atelocollagen absorbable punctal plugs. Clin Ophthalmol 2012 ; 6 : 133-138.

9 上流のリスクとその治療 / 蒸発亢進

P.294 掲載の参考文献

1 天野史郎 (マイボーム腺機能不全ワーキンググループ) : マイボーム腺機能不全の定義と診断基準. あたらしい眼科 2010 ; 27 : 627-631.

2 Research in dry eye : report of the Research Subcommittee of the International Dry Eye WorkShop (2007). Ocul Surf 2007 ; 5 : 179-193.

3 Maskin SL : Intraductal meibomian gland probing relieves symptoms of obstructive meibomian gland dysfunction. Cornea 2010 ; 29 : 1145-1152.

4 Korb DR, et al : Case report : a successful LipiFlow treatment of a single case of meibomian gland dysfunction and dropout. Eye Contact Lens 2013 ; 39 : e1-3.

5 Goto E, et al : Successful tear lipid layer treatment for refractory dry eye in office workers by low-dose lipid application on the full-length eyelid margin. Am J Ophthalmol 2006 ; 142 : 264-270.

P.297 掲載の参考文献

1 川北哲也ら : 日本における毛嚢虫性前部眼瞼縁炎. 日本眼科学会雑誌 2010 ; 114 : 1025-1029.

2 Kojima T, et al : In vivo evaluation of ocular demodicosis using laser scanning confocal microscopy. Invest Ophthalmol Vis Sci 2011 ; 52 : 565-569.

3 Lee SH, et al : The relationship between demodex and ocular discomfort. Invest Ophthalmol Vis Sci 2010 ; 51 : 2906-2911.

4 Kemal M, et al : The prevalence of Demodex folliculorum in blepharitis patients and the normal population. Ophthalmic Epidemiol 2005 ; 12 : 287-290.

5 Gao YY, et al : In vitro and in vivo killing of ocular Demodex by tea tree oil. Br J Ophthalmol 2005 ; 89 : 1468-1473.

P.299 掲載の参考文献

1 鈴木智ら : マイボーム腺炎に関連した角膜上皮障害 (マイボーム腺炎角膜上皮症) の検討. あたらしい眼科 2000 ; 17 : 423-427.

2 Suzuki T, et al : Phlyctenular keratitis associated with meibomitis in young patients. Am J Ophthalmol 2005 ; 140 : 77-82.

3 Suzuki T, et al : Ocular surface inflammation induced by Propionibacterium acnes. Cornea 2002 ; 21 : 812-817.

P.305 掲載の参考文献

1 Uchiyama E, et al : Increased evaporative rates in laboratory testing conditions simulating airplane cabin relative humidity : an important factor for dry eye syndrome. Eye Contact Lens 2007 ; 33 : 174-176.

2 Pelegrino FS, et al : Low humidity environmental challenge causes barrier disruption and cornification of the mouse corneal epithelium via a c-jun N-terminal kinase 2 (JNK2) pathway. Exp Eye Res 2012 ; 94 : 150-156.

3 Toda I, et al : Decreased tear break-up time (BUT) is somtimes associated with allergic conjunctivitis., Ophthalmology 1995 ; 102 : 302-309.

4 Uchino M, et al : Prevalence of dry eye disease among Japanese visual display terminal users. Ophthalmology 2008 ; 115 : 1982-1988.

5 Nakamura S, et al : Lacrimal hypofunction as a new mechanism of dry eye in visual display terminal users. PLoS ONE 2010 ; 15 ; 5 : e11119.

6 Li M, et al : Assessment of vision-related quality of life in dry eye patients. Invest Ophthalmol Vis Sci 2012 ; 53 : 5722-5727.

7 Miljanovic B, et al : Impact of dry eye syndrome on vision-related quality of life. Am J Ophthalmol 2007 ; 143 : 409-415.

8 Altinors DD, et al : Smoking associated with damage to the lipid layer of the ocular surface. Am J Ophthalmol 2006 ; 141 : 1016-1021.

9 El-Shazly AA, et al : Passive smoking as a risk factor of dry eye in children. J Ophthalmol 2012 ; 2012 : 130159.

10 Wojtowicz JC, et al : Pilot, prospective, randomized, double-masked, placebo-controlled clinical trial of an omega-3 supplement for dry eye. Cornea 2011 ; 30 : 308-314.

P.308 掲載の参考文献

1 横井則彦 : コンタクトレンズと眼表面上皮・涙液の生理環境. 日本コンタクトレンズ学会誌 1997 ; 39 : 111-115.

2 Gipson IK : Distribution of mucins at the ocular surface. Exp Eye Res 2004 ; 78 : 379-388.

3 Nichols JJ, et al : Thickness of the pre-and post-contact lens tear film measured in vivo by interferometry. Invest Opthalmol Vis Sci 2003 ; 44 : 68-77.

4 丸山邦夫ら : コンタクトレンズ装用眼のティアダイナミクス. 日本コンタクトレンズ学会誌 2003 ; 45 : 60-65.

5 Yokoi N, et al : Dynamics changes in tear meniscuc curvature at the rigid contact lens edge. Cornea 2003 ; 22 : 226-229.

6 McDonald JE, et al : Meniscuc-induced thinning of the tear film. Am J Opthalmol 1971 ; 72, 139-146.

7 Itoh R, et al : Tear film instability induced by hard contact lenses. Cornea 1999 ; 18 : 440-443.

8 Yokoi N, et al : Rheology tear film lipid layer spread in normal and aqueous tear-deficient dry eyes. Invest Ophthalmol Vis Sci 2008 ; 49 : 5319-5324.

9 Chen Qi, et al : Tear menisci and ocular discomfort during daily contact lens wear in symptomatic wearers. Invest Opthalmol Vis Sci 2011 ; 52 : 2175-2180.

10 Korb DR, et al : Lid-wiper epitheliopathy and dry-eye symptoms in contact lens wearers. CLAO J 2002 ; 28 : 211-216.

11 Maissa C, et al : Contact lens-induced circumlimbal staining in silicone hydrogel contact lenses worn on a daily wear basis. Eye Contact Lens 2012 ; 38 : 16-26.

12 Covey M, et al : Hypoxic effects on the anterior eye of high-Dk soft contact lens wearers are negligible. Optom Vis Sci 2001 ; 78 : 95-99.

13 Guillon M, et al : Bulbar conjunctival staining in contact lens wearers and non lens wearers and its association with symptomatology. Cont Lens Anterior Eye 2005 ; 28 : 67-73.

14 Morgan PB, et al : International contact lens prescribing in 2012. CL Spectrum 2013 ; 28 : 31-38.

15 Richdale K, et al : Frequency of and factors associated with contact lens dissatisfaction and discontinuation. Cornea 2007 ; 26 : 168-174.

16 Maruyama K, et al : Effects environmental conditions on tear dynamics in soft contact lens wearers. Invest Opthalmol Vis Sci 2004 ; 45 : 2563-2568.

P.313 掲載の参考文献

1 島崎潤 : ドライアイの診断とリスクファクターの考え方. 眼科 2011 ; 53 : 1553-1557.

2 横井則彦ら : 今日のコンタクトレンズ診療 2. 素材の変化による臨床的価値 (シリコーンハイドロゲルレンズを含む). 眼科 2012 ; 54 : 595-602.

3 島崎潤 (ドライアイ研究会) : 2006年ドライアイ診断基準. あたらしい眼科 2007 ; 24 : 181-184.

4 横井則彦 : ドライアイの新しい治療戦略-眼表面の層別治療. 日本の眼科 2012 ; 83 : 1318-1322.

5 佐野研二 : コンタクトレンズ素材とその進歩. 日本コンタクトレンズ学会誌 2008 ; 50 : 13-23.

6 工藤昌之ら : シリコーンハイドロゲルコンタクトレンズと消毒剤との相性. あたらしい眼科 2005 ; 22 : 1349-1355.

7 Dumbleton K, et al : The evolution of CL wetting agents. Contact Lens Spectrum Oct 2009 : 20.

8 Chalmers R, et al : Improving contact-lens related dryness symptoms with silicone hydrogel lenses. Optom Vis Sci 2008 ; 85 : 778-784.

P.316 掲載の参考文献

1 島崎潤 (ドライアイ研究会) : 2006年ドライアイ診断基準. あたらしい眼科 2007 ; 24 : 181-184.

2 濱野孝 : ドライアイ. 大橋裕一編. 専門医のための眼科診療クオリファイ 6 コンタクトレンズ自由自在. 東京 : 中山書店 ; 2011. p.178-181.

3 土至田宏 : 身近な目の病気ドライアイ. Eye Bank Journal 2004 ; 8 : 48-49.

P.318 掲載の参考文献

1 Shepard DS, et al : Economic appraisal of the Boston ocular surface prosthesis. Am J Ophthalmol 2009 ; 148 : 860-868.

2 Nakamura T, et al : New hopes and strategies for the treatment of severe ocular surface disease. Curr Opin Ophthalmol 2011 ; 22 : 274-278.

10 上流のリスクとその治療 / 瞬目時の摩擦亢進

P.324 掲載の参考文献

1 Meller D, et al : Conjunctivochalasis : literature review and possible pathophysiology. Surv Ophthalmol 1998 ; 43 : 225-232. Review.

2 Yokoi N, et al : Surgery of the conjunctiva. Dev Ophthalmol 2008 ; 41 : 138-158. Review.

3 Yokoi N, et al : Clinical impact of conjunctivochalasis on the ocular surface. Cornea 2005 ; 24 : S24-S31.

4 Yokoi N, et al : New surgical treatment for superior limbic keratoconjunctivitis and its association with conjunctivochalasis. Am J Ophthalmol 2003 ; 135 : 303-308.

P.326 掲載の参考文献

1 Theodore FH : Superior limbic keratoconjunctivitis. Eye Ear Nose Throat Mon 1963 ; 42 : 25-28.

2 Cher I : Blink-related microtrauma : when the ocular surface harms itself. Clin Experimental Ophthalmology 2003 ; 31 : 183-190.

3 Sheu MC, et al : Development of superior limbic keratoconjunctivitis after upper eyelid blepharoplasty surgery : support for the mechanical theory of its pathogenesis. Cornea 2007 ; 26 : 490-492.

4 Sun YC, et al : Overexpression of matrix metalloproteinase-1 (MMP-1) and MMP-3 in superior limbic keratoconjunctivitis. Invest Ophthalmol Vis Sci 2011 ; 52 : 3701-3705.

5 Udell IJ, et al : Treatment of superior limbic keratoconjunctivitis by thermocauterization of the superior bulbar conjunctiva. Ophthalmology 1986 ; 93 : 162-166.

6 Yokoi N, et al : New Surgical treatment for superior limbic keratoconjunctivitis and its association with conjunctivochalasis. Am J Ophthalmol 2003 ; 135 : 303-308.

7 Yamada M, et al : Conjunctival fixation sutures for refractory superior limbic keratoconjunctivitis. Br J Ophthalmol 2009 ; 93 : 1570-1571.

8 Chun YS, et al : Treatment of superior limbic keratoconjunctivitis with a large-diameter contact lens and Botulium Toxin A. Cornea 2009 ; 28 : 752-758.

9 Sahin A, et al : Topical cyclosporine a in the treatment of superior limbic keratoconjunctivitis : a long-term follow-up. Cornea 2008 ; 27 : 193-195.

10 Ohashi Y, et al : Vitamin A eyedrops for superior limbic keratoconjunctivitis. Am J Ophthalmol 1998 ; 15 ; 523-527.

11 Kadrmas EF, et al : Superior limbic keratoconjunctivitis. A prognostic sign for severe Graves ophthalmopathy. Ophthalmology 1995 ; 102 : 1472-1475.

P.329 掲載の参考文献

1 Korb DR, et al : Lid-wiper epitheliopathy and dry-eye symptoms in contact lens wearers. CLAO J 2002 ; 28 : 211-216.

2 Cher I : Blink-related microtrauma : when the ocular surface harms itself. Clin Experiment Ophthalmol 2003 ; 31 : 183-190.

3 白石敦ら : ドライアイ症状患者におけるlid-wiper epitheliopathyの発現頻度. 日本眼科学会雑誌 2009 ; 113 : 596-600.

4 Korb DR, et al : Lid wiper epitheliopathy and dry eye symptoms. Eye Contact Lens 2005 ; 31 : 2-8.

P.332 掲載の参考文献

1 Kakizaki H, et al : Filamentary keratitis improved by blepharoptosis surgery : two cases. Acta Ophthalmol Scand 2003 ; 81 : 669-671.

2 北澤耕司ら : 難治性糸状角膜炎に対する眼瞼手術の検討. 日本眼科学会雑誌 2011 ; 115 : 693-698.

3 Kinoshita S, et al : Filamentary keratitis. 4th ed. Philadelphia : Lippincott Williams & Wilkins ; 2005. p.687-692.

4 Wright P : Filamentary keratitis. Trans Ophthalmol Soc UK 1975 ; 95 : 260-266.

5 Zaidman GW, et al : The histopathology of filamentary keratitis. Arch Opthalmol 1985 ; 103 : 1178-1181.

6 Tanioka H, et al : Investigation of the corneal filament in filamentary keratitis. Invest Ophthalmol Vis Sci 2009 ; 50 : 3696-3702.

P.335 掲載の参考文献

1 日本神経眼科学会眼瞼けいれん診療ガイドライン委員会 : 眼瞼けいれん診療ガイドライン. 日本眼科学会雑誌 2011 ; 115 : 617-628.

2 Micheli F, et al : Development of Parkinson's disease in patients with blepharospasm. Mov Disord 2004 ; 19 : 1069-1072.

3 山口昌彦 : ドライアイの最近の話題 2011-ドライアイにおけるまぶたの重要性. 眼科 2011 ; 53 : 1599-1608.

4 若倉雅登ら : 眼瞼けいれん患者における2006年ドライアイ診断基準の適用. 臨床眼科 2008 ; 62 : 857-860.

5 Tsubota K, et al : Dry eye and Meige's syndrome. Br J Ophthalmol 1997 ; 81 : 439-442.

11 上流のリスクとその治療 / 眼表面上皮の水濡れ性低下

P.340 掲載の参考文献

i 中村隆宏 : 難治性眼表面疾患における病的角化の分子機構. 日本眼科学会雑誌 2004 ; 108 : 654-664.

ii McNamara N : Molecular mechanisms of keratinizing ocular surface disease. Optom Vis Sci 2010 ; 87 : 233-238.

iii Koh S, et al : Development of methicillin-resistant Staphylococcus aureus keratitis in a dry eye patient with a therapeutic contact lens. Eye Contact Lens 2012 ; 38 : 200-202.

12 複合リスク

P.348 掲載の参考文献

1 The epidemiology of dry eye disease : report of the epidemiology subcommittee of the International Dry Eye WorkShop (2007). Ocul Surf 2007 ; 5 : 93-107.

2 Uchino M, et al : The features of dry eye disease in a Japanese elderly population. Optom Vis Sci 2006 ; 83 : 797-802.

3 Stern ME, et al : The pathology of dry eye : the interaction between the ocular surface and lacrimal glands. Cornea 1998 ; 17 : 584-589.

4 Sullivan BD, et al : Influence of aging on the polar and neutral lipid profiles in human meibomian gland secretions. Arch Ophthalmol 2006 ; 124 : 1286-1292.

5 Patel S, et al : Age-related changes in precorneal tear film stability. Optom Vis Sci 1989 ; 66 : 175-178.

6 Mathers WD, et al : Tear film changes associated with normal aging. Cornea 1996 ; 15 : 229-334.

7 Rocha EM, et al : The aging lacrimal gland : changes in structure and function. Ocul Surf 2008 ; 6 : 162-174.

8 Rios JD, et al : Age-dependent alterations in mouse exorbital lacrimal gland structure, innervation and secretory response. Exp Eye Res 2005 ; 80 : 477-491.

9 Obata H, et al : Histopathologic study of human lacrimal gland. Statistical analysis with special reference to aging. Ophthalmology 1995 ; 102 : 678-686.

10 Draper CE, et al : Age-related changes in morphology and secretory responses of male rat lacrimal gland. J Auton Nerv Syst 1998 ; 69 : 173-183.

11 Shimazaki J, et al : Ocular surface changes and discomfort in patients with meibomian gland dysfunction. Arch Ophthalmol 1995 ; 113 : 1266-1270.

12 Schaumberg DA, et al : The international workshop on meibomian gland dysfunction : report of the subcommittee on the epidemiology of, and associated risk factors for, MGD. Invest Ophthalmol Vis Sci 2011 ; 52 : 1994-2005.

13 Arita R, et al : Noncontact infrared meibography to document age-related changes of the meibomian glands in a normal population. Ophthalmology 2008 ; 115 : 911-915.

14 Kawashima M, et al : Calorie restriction : A new therapeutic intervention for age-related dry eye disease in rats. Bioche Biophys Res Commun 2010 ; 397 : 724-728.

15 Kojima T, et al : Age-related dysfunction of the lacrimal gland and oxidative stress : evidence from the Cu, Zn-superoxide dismutase-1 (Sod1) knockout mice. Am J Pathol 2012 ; 180 : 1879-1896.

P.353 掲載の参考文献

1 Schaumberg DA, et al : Hormone replacement therapy and dry eye syndrome. JAMA 2001 ; 286 : 2114 -2119.

2 Wickham LA, et al : Identification of androgen, estrogen, and progesterone receptor mRNAs in the eye. Acta Ophthalmol Sacnd 2000 ; 78 : 146-153.

3 Schirra F, et al : Androgen control of gene expression in the mouse meibomian gland. Invest Ophthalmol Vis Sci 2005 ; 46 : 3666-3675.

4 Schirra F, et al : Identification of steroidgenic enzyme mRNAs in the human lacrimal gland, meibomian gland, cornea, and conjunctiva. Cornea 2006 ; 25 : 438-442.

5 Schirra F, et al : Androgen regulation of lipogenic pathways in the mouse meibomian gland. Exp Eye Res 2006 ; 83 : 291-296.

6 Worda C, et al : Treatment of keratoconjunctivitis sicca with topical androgen. Maturitas 2001 ; 37 : 209-212.

7 Suzuki T, et al : Estrogen and progesterone effects on the morphology of the mouse meibomian gland. Adv Exp Med Biol 2002 ; 506 : 483-488.

8 Suzuki T, et al : Estrogen and progesterone control of gene expression in the mouse meibomian gland. Invest Ophthalmol Vis Sci 2008 ; 49 : 1797-1808.

P.355 掲載の参考文献

1 Wong J, et al : Non-hormonal systemic medications and dry eye. Ocul Surf 2011 ; 9 : 212-226.

2 Dursun D, et al : A mouse model of keratoconjunctivitis sicca. Invest Ophthalmol Vis Sci 2002 ; 43 : 632-638.

3 Ness J, et al : Anticholinergic medications in community-dwelling older veterans : prevalence of anticholinergic symptoms, symptom burden, and adverse drug events. Am J Geriatr Pharmacother 2006 ; 4 : 42-51.

4 Altan-Yaycioglu R, et al : Ocular side-effects of tolterodine and oxybutynin, a single-blind prospective randomized trial. Br J Clin Pharmacol 2005 ; 59 : 588-592.

5 Ousler GW, et al : An evaluation of the ocular drying effects of 2 systemic antihistamines : loratadine and cetirizine hydrochloride. Ann Allergy Asthma Immunol 2004 ; 93 : 460-464.

6 Ousler GW, et al : An open-label, investigator-masked, crossover study of the ocular drying effects of two antihistamines, topical epinastine and systemic loratadine, in adult volunteers with seasonal allergic conjunctivitis. Clin Ther 2007 ; 29 : 611-616.

7 Balik J, et al : Effect of atropine & pilocarpine on the secretion of chloride ions into the tears. Cesk Oftalmol 1958 ; 14 : 28-33.

8 Erickson OF : Drug influences on lacrimal lysozyme production. Stanford Med Bull 1960 ; 18 : 34-39.

P.358 掲載の参考文献

1 Ness J, et al : Anticholinergic medications in community-dwelling older veterans : prevalence of anticholinergic symptoms, symptom burden, and adverse drug events. Am J Geriatr Pharmacother 2006 ; 4 : 42-51.

2 Ousler GW, et al : An evaluation of the ocular drying effects of 2 systemic antihistamines : loratadine and cetirizine hydrochloride. Ann Allergy Asthma Immunol 2004 ; 93 : 460-464.

3 Ousler GW, et al : An open-label, investigator-masked, crossover study of the ocular drying effects of two antihistamines, topical epinastine and systemic loratadine, in adult volunteers with seasonal allergic conjunctivitis. Clin Ther 2007 ; 29 : 611-616.

P.363 掲載の参考文献

1 De Saint JM, et al : Effects of benzalkonium chloride on growth and survival of Chang conctival cells. Invest Ophthalmol Vis Sci 1999 ; 40 : 619-630.

2 Nakagawa S, et al : Toxicity evaluation of antiglaucoma drugs using stratified human cultivated corneal epithelial sheets. Invest Ophthalmol Vis Sci 2012 ; 53 : 5154-5160.

P.366 掲載の参考文献

1 Taehoon O, et al : Changes in the tear film and ocular surface after cataract surgery. Jpn J Ophthalmol 2012 ; 56 : 113-118.

2 Li XM, et al : Investigation of dry eye disease and analysis of the pathogenic factors in patients after cataract surgery. Cornea 2007 ; 26 : 16-20.

3 Khanal S, et al : Changes in corneal sensitivity and tear physiology after phacoemulsification. Ophthalmic Physiol Opt 2008 ; 28 : 127-134.

4 Ram J, et al : Outcomes of phacoemulsification in patients with dry eye. J Cataract Refract Surg 2002 ; 28 : 1386-1389.

5 Hoffman RS, et al : New phacoemulsification technology. Curr Opin Ophthalmol 2005 ; 16 : 38-43.

6 Toda I, et al : Dry eye after laser in situ keratomileusis. Am J Ophthalmol 2001 ; 132 : 1-7.

P.368 掲載の参考文献

1 Wilson S : Laser in situ keratomileusis-induced (presumed) neurotrophic epitheliopathy. Ophthalmology 2001 ; 108 : 1082-1087.

2 Toda I, et al : Dry eye following laser in situ keratomileusis. Am J Ophthalmol 2001 ; 132 : 1-7.

3 Lee B, et al : Reinnervation in the cornea after LASIK. Invest Ophthalmol Vis Sci 2002 ; 43 : 3660-3664.

4 Toda I, et al : Laser in situ keratomileusis for patients with dry eye. Arch Ophthalomology 2002 ; 120 : 1024-1028.

13 眼表面疾患とドライアイ

P.372 掲載の参考文献

1 Ferrara JL, et al : Graft-versus-host disease. Lancet 2009 ; 373 : 1550-1561.

2 Blazar BR, et al : Advances in graft-versus-host disease biology and therapy. Nat Rev Immunol 2012 ; 12 : 443-458.

3 Ogawa Y, et al : Dry eye after haematopoietic stem cell transplantation. Br J Ophthalmol 1999 ; 83 : 1125-1130.

4 小川葉子 : II. 臨床編 : 診断. 5. 眼科からみたGVHD. 豊嶋崇徳編. みんなに役立つGVHD (移植片対宿主病) の基礎と臨床. 大阪 : 医薬ジャーナル社 ; 2013. p.171-184.

5 Uchino M, et al : Ocular complications in a child with acute graft-versus-host disease following cord blood stem cell transplantation : therapeutic challenges. Acta Ophthalmol Scand 2006 ; 84 : 545-548.

6 Ogawa Y, et al : Donor fibroblast chimerism in the pathogenic fibrotic lesion of human chronic graft-versus-host disease. Invest Ophthalmol Vis Sci 2005 ; 46 : 4519-4527.

7 Ogawa Y, et al : Epithelial mesenchymal transition in human ocular chronic graft-versus-host disease. Am J Pathol 2009 ; 175 : 2372-2381.

8 Jabs DA, et al : The eye in bone marrow transplantation. III. Conjunctival graft-vs-host disease. Arch Ophthalmol 1989 ; 107 : 1343-1348

9 Robinson MR, et al : Topical corticosteroid therapy for cicatricial conjunctivitis associated with chronic graft-versus-host disease. Bone Marrow Transplant 2004 ; 33 : 1031-1035.

10 Townley JR, et al : Keratoconjunctivitis sicca manifestations in ocular graft versus host disease : pathogenesis, presentation, prevention, and treatment. Semin Ophthalmol 2011 ; 26 : 251-260.

11 Ogawa Y, et al : Immune processes and pathogenic fibrosis in ocular chronic graft-versus-host disease and clinical manifestations after allogeneic hematopoietic stem cells transplantation. Cornea 2010 ; 29 : S68-S77.

12 Shikari H, et al : Ocular graft-versus-host disease : a review. Surv Ophthalmol 2013 ; 58 : 233-251.

P.376 掲載の参考文献

1 Mockenhaupt M, et al : Stevens-Johnson syndrome and toxic epidermal necrolysis : assessment of medication risks with emphasis on recently marketed drugs. The EuroSCAR-study. J Invest Dermatol 2008 ; 128 : 35-44.

2 Roujeau JC, et al : Medication use and the risk of Stevens-Johnson syndrome or toxic epidermal necrolysis. N Engl J Med 1995 ; 333 : 1600-1607.

3 Yamane Y, et al : Analysis of Stevens-Johnson syndrome and toxic epidermal necrolysis in Japan from 2000 to 2006. Allergol Int 2007 ; 58 : 419-425.

4 北見周ら : Stevens-Johnson症候群ならびに中毒性表皮壊死症の全国疫学調査-平成20年度厚生労働科学研究費補助金 (難治性疾患克服研究事業) 重症多形滲出性紅斑に関する調査研究-. 日本皮膚科学会雑誌 2011 ; 121 : 2467-2482.

5 Ueta M, et al : Toll like receptor 3 gene polymorphisms in Japanese patients with Stevens-Johnson syndrome. Br J Ophthalmol 2007 ; 91 : 962-965.

6 Ueta M, et al : Association between prostaglandin E receptor 3 polymorphisms and Stevens-Johnson syndrome identified by means of a genome-wide association study. J Allergy Clin Immunol 2010 ; 126 : 1218-1225.

7 Sotozono C, et al : Diagnosis and treatment of Stevens-Johnson syndrome and toxic epidermal necrolysis with ocular complications. Ophthalmology 2009 ; 116 : 685-690.

8 木下茂ら : 再生医学による重症角膜疾患の新規治療法開発への戦略的研究. 最新医学 2007 ; 62 : 132-180.

9 Ohji M, et al : Goblet cell density in thermal and chemical injuries. Arch Ophthalmol 1987 ; 105 : 1686-1688.

書評

書評を投稿する

最近チェックした商品履歴

Loading...